Activities

The Research Group - Genome brings together expertise in molecular biology, biostatistics and bioinformatics to identify the genomic alterations occurring in tumours and to understand their contribution to cancer biology. Major research interests primarily focus on brain cancers and include the role of tumour heterogeneity and of cross-talk between tumour cells and their microenvironment in the progression and response to therapy. Cutting-edge technologies, such as single-cell sequencing and sophisticated bioinformatics methods are used to generate high resolution information with the ultimate goal of translating genomics data into greater precision cancer diagnosis and treatment.

Essential to research group’s mission is a close collaboration with key partners, including the Norlux Neuro-oncology laboratory (LIH), University of Luxembourg (Life Science Department & Luxembourg Centre for Systems Biomedicine), University of Lorraine (Nancy, France), Institut de génétique humaine (Montpellier, France), and DKFZ (Heidelberg, Germany).

Research projects

  • Contribution of microRNAome and transcriptome in the progression from chronic hypertension to heart failure in the context of a metabolic syndrome. Project funded by MCESR.
  • Inflammatory microRNAs in liver cancer. INTER project funded by FNR and coordinated by Prof. Iris Behrmann, University of Luxembourg.
  • Dissecting cell autonomous roles of integrin beta3. Core Project funded by FNR and coordinated by Dr Jochen Schneider, University of Luxembourg.

As a service provider, the research group participates each year in 10-15 genomics studies mainly focused on cancer themes.

Featured Publications

A DNA repair and cell-cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications.

  • NORLUX-DNA repair and chemoresistance
  • Bioinformatics and Modelling
  • NORLUX-Glioma Biology
March 15, 2019
2019 Mar. Cancer Res.79(6):1226-1238. Epub 2019 Jan 23.
By:
  • Gobin M
  • Nazarov PV
  • Warta R
  • Timmer M
  • Reifenberger G
  • Felsberg J
  • Vallar L
  • Chalmers AJ
  • Herold-Mende CC
  • Goldbrunner R
  • Niclou SP
  • Van Dyck E.

Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.

  • Bioinformatics and Modelling
November 01, 2018
2018 Nov. J Leukoc Biol.104(5):987-1002. Epub 2018 Aug 26.
By:
  • Kirchmeyer M
  • Servais FA
  • Hamdorf M
  • Nazarov PV
  • Ginolhac A
  • Halder R
  • Vallar L
  • Glanemann M
  • Rubie C
  • Lammert F
  • Kreis S
  • Behrmann I.
See all publications

Contact

Gunnar Dittmar

Ph.D.

1A-B, rue Thomas Edison
1445 Strassen
Luxembourg
Tel. : +352 26970-944