Activities

 The main focus is the investigation of the immune response after vaccination and the development of new vaccination strategies. In the FLUTCORE project we develop a novel universal influenza vaccine based on virus-like particles (VLP) carrying invariant influenza antigens. The project is funded by the EU framework Programme 7.

In another project we use a reverse vaccinology approach to develop a vaccine against ticks and tick-borne pathogens. In this context we have recently sequenced the genome of the most important disease vector in Western Europe, the Ixodes ricinus tick.

In a third project we develop an immunoprophylactic strategy against detrimental effects of environmental toxins such as the ubiquitous carcinogen Benzo [A] pyrene. Early mutagenous and DNA damage are measured by highly sensitive NGS-based techniques.

In these studies the immune response is monitored at the level of the variable regions of the T and B cell receptor using multiple parallel sequencing.

Research projects

  • Development of a universal influenza vaccine based on tandem core technology (EU Framework 7 project FLUTCORE)
  • Vaccination against ticks and tick-borne pathogens based on a reverse vaccinology approach
  • Immunoprophylactic strategy against chemical carcinogenesis
  • Molecular signatures of the B cell repertoire in infectious diseases (borreliosis, influenza, measles) and after vaccination (e.g. chemicals, haptens, BaP)

Featured Publications

Varicella zoster and fever rash surveillance in Lao People's Democratic Republic.

  • Vaccinology and B Cell Immunology
  • Clinical and Applied Virology
May 08, 2019
2019 May. BMC Infect Dis.19(1):392.
By:
  • Nouanthong P
  • Hubschen JM
  • Billamay S
  • Mongkhoune S
  • Vilivong K
  • Khounvisith V
  • Sinner R
  • Grandadam M
  • Phonekeo D
  • Black AP
  • Muller CP.

Detection of a low level and heterogeneous B cell immune response in peripheral blood of acute borreliosis patients with high throughput sequencing.

  • Vaccinology and B Cell Immunology
May 01, 2019
2019 May. Front Immunol.10:1105.
By:
  • Kirpach J
  • Colone A
  • Burckert JP
  • Faison WJ
  • Dubois A
  • Sinner R
  • Reye AL
  • Muller CP.
See all publications

Contact

Claude Muller

M.D.

University of Trier - University of Homburg/Saarland - University of Nancy

29, rue Henri Koch
L-4354 Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-621