The HIV Clinical and Translational Research (HIV-CTR) Group is interested in clinically oriented research in the field of resistance to antiviral therapy and transmission, as well as providing new translational knowledge on HIV cure and on HIV immunopathogenesis using humanized mouse models. The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in emerging countries (mainly in Africa) to support knowledge and technology transfer. The Group provides specialized technical support for the clinical follow-up of HIV and HCV-infected patients and is the first supplier of public health information for these infections in Luxembourg.


Research projects

  • HIV Molecular Epidemiology in Europe, the SPREAD surveillance program
  • Toxicomania, hepatitis C and substitution: epidemiological, behavioral and clinical study in Luxembourg
  • Development of heteromultimeric multifunctional therapeutic molecules activating the complement action towards target cells
  • Assessment of the sequential events driving immune activation in the gut during acute HIV infection by using an in vivo model of humanized mice
  • Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery

Featured Publications

FHR4-based immunoconjugates direct complement-dependent cytotoxicity and phagocytosis toward HER2-positive cancer cells.

  • HIV Clinical and Translational Research
  • Immuno-Pharmacology and Interactomics
  • Dimensional Immuno-Cytometry
July 31, 2019
2019 Jul. Mol Oncol. [Epub ahead of print].
  • Seguin-Devaux C
  • Plesseria JM
  • Verschueren C
  • Masquelier C
  • Iserentant G
  • Fullana M
  • Jozsi M
  • Cohen JHM
  • Dervillez X.

EMCDDA Case study 5 — Expanding HCV screening and hepatitis treatment and care for PWID to harm reduction centres. In Hepatitis C: new models of care for drugs services. (Book Chapter)

  • HIV Clinical and Translational Research
July 01, 2019
2019 Jul. EMCDDA, 2019. p.43-49. ISBN NA.
  • Devaux C
  • Arendt V.
See all publications


Carole Devaux


29, rue Henri Koch
L-4354 Esch-sur-Alzette
Tel. : +352 26970-224