Activities

The HIV Clinical and Translational Research (HIV-CTR) Group is interested in clinically oriented research in the field of resistance to antiviral therapy and transmission, as well as providing new translational knowledge on HIV cure and on HIV immunopathogenesis using humanized mouse models. The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in emerging countries (mainly in Africa) to support knowledge and technology transfer. The Group provides specialized technical support for the clinical follow-up of HIV and HCV-infected patients and is the first supplier of public health information for these infections in Luxembourg.

Collaborations:

Research projects

  • HIV Molecular Epidemiology in Europe, the SPREAD surveillance program
  • Toxicomania, hepatitis C and substitution: epidemiological, behavioral and clinical study in Luxembourg
  • Development of heteromultimeric multifunctional therapeutic molecules activating the complement action towards target cells
  • Assessment of the sequential events driving immune activation in the gut during acute HIV infection by using an in vivo model of humanized mice
  • Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery

Featured Publications

Pharmacokinetics of Efavirenz in 2-3 years old children: a high dose of 25 mg/kg per day.

  • HIV Clinical and Translational Research
May 08, 2017
2017 May. Antimicrob Agents Chemother. [Epub ahead of print].
By:
  • Pressiat C
  • Amorissani-Folquet M
  • Yonaba C
  • Treluyer JM
  • Dahourou DL
  • Eboua F
  • Blanche S
  • Mea-Assande V
  • Bouazza N
  • Foissac F
  • Malateste K
  • Ouedraogo S
  • Lui G
  • Leroy V
  • Hirt D
  • MONOD Study Group (Devaux C as collaborator for this project).

Virological response and resistances over 12 months among HIV-infected children less than two years receiving first-line lopinavir/ritonavir-based antiretroviral therapy in Cote d’Ivoire and Burkina Faso: the MONOD ANRS 12206 cohort.

  • HIV Clinical and Translational Research
April 25, 2017
2017 Apr. J Int AIDS Soc.20:21362.
By:
  • Amani-Bosse C
  • Dahourou DL
  • Malateste K
  • Amorissani-Folquet M
  • Coulibaly M
  • Dattez S
  • Emieme A
  • Barry M
  • Rouzioux C
  • N’Gbeche S
  • Yonaba C
  • Timité-Konan M
  • Mea V
  • Ouédraogo S
  • Blanche S
  • Meda N
  • Seguin-Devaux C
  • Leroy V.
See all publications

Contact

Carole Devaux

Ph.D.

29, rue Henri Koch
L-4354 Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-224