The HIV Clinical and Translational Research (HIV-CTR) Group is interested in clinically oriented research in the field of resistance to antiviral therapy and transmission, as well as providing new translational knowledge on HIV cure and on HIV immunopathogenesis using humanized mouse models. The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in emerging countries (mainly in Africa) to support knowledge and technology transfer. The Group provides specialized technical support for the clinical follow-up of HIV and HCV-infected patients and is the first supplier of public health information for these infections in Luxembourg.


Research projects

  • HIV Molecular Epidemiology in Europe, the SPREAD surveillance program
  • Toxicomania, hepatitis C and substitution: epidemiological, behavioral and clinical study in Luxembourg
  • Development of heteromultimeric multifunctional therapeutic molecules activating the complement action towards target cells
  • Assessment of the sequential events driving immune activation in the gut during acute HIV infection by using an in vivo model of humanized mice
  • Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery

Featured Publications

Restrictions for reimbursement of interferon-free direct-acting antiviral drugs for HCV infection in Europe.

  • HIV Clinical and Translational Research
October 03, 2017
2017 Oct. Lancet Gastroenterol Hepatol. [Epub ahead of print].
  • Marshall AD
  • Cunningham EB
  • Nielsen S
  • Aghemo A
  • Alho H
  • Backmund M
  • Bruggmann P
  • Dalgard O
  • Seguin-Devaux C
  • Flisiak R
  • Foster GR
  • Gheorghe L
  • Goldberg D
  • Goulis I
  • Hickman M
  • Hoffmann P
  • Jancoriene L
  • Jarcuska P
  • Kaberg M
  • Kostrikis LG
  • Makara M
  • Maimets M
  • Marinho RT
  • Maticic M
  • Norris S
  • Olafsson S
  • Ovrehus A
  • Pawlotsky JM
  • Pocock J
  • Robaeys G
  • Roncero C
  • Simonova M
  • Sperl J
  • Tait M
  • Tolmane I
  • Tomaselli S
  • van der Valk M
  • Vince A
  • Dore GJ
  • Lazarus JV
  • Grebely J
  • International Network on Hepatitis in Substance Users (INHSU).

T cell immunosenescence after early life adversity: association with cytomegalovirus infection.

  • Immune Endocrine and Epigenetics
  • HIV Clinical and Translational Research
  • Vaccinology and B Cell Immunology
September 22, 2017
2017 Sep. Front Immunol.8:1263.
  • Elwenspoek MMC
  • Sias K
  • Hengesch X
  • Schaan VK
  • Leenen FAD
  • Adams P
  • Meriaux SB
  • Schmitz S
  • Bonnemberger F
  • Ewen A
  • Schachinger H
  • Vogele C
  • Muller CP
  • Turner JD.
See all publications


Carole Devaux


29, rue Henri Koch
L-4354 Esch-sur-Alzette
Tel. : +352 26970-224