The HIV Clinical and Translational Research (HIV-CTR) Group is interested in clinically oriented research in the field of resistance to antiviral therapy and transmission, as well as providing new translational knowledge on HIV cure and on HIV immunopathogenesis using humanized mouse models. The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in emerging countries (mainly in Africa) to support knowledge and technology transfer. The Group provides specialized technical support for the clinical follow-up of HIV and HCV-infected patients and is the first supplier of public health information for these infections in Luxembourg.


Research projects

  • HIV Molecular Epidemiology in Europe, the SPREAD surveillance program
  • Toxicomania, hepatitis C and substitution: epidemiological, behavioral and clinical study in Luxembourg
  • Development of heteromultimeric multifunctional therapeutic molecules activating the complement action towards target cells
  • Assessment of the sequential events driving immune activation in the gut during acute HIV infection by using an in vivo model of humanized mice
  • Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery

Featured Publications

Multicenter evaluation of the cobas® HIV-1 quantitative nucleic acid test for use on the cobas® 4800 system for the quantification of HIV-1 plasma viral load.

  • HIV Clinical and Translational Research
May 01, 2019
2019 May. J Clin Virol.114:43-49.
  • Adams P
  • Vancutsem E
  • Nicolaizeau C
  • Servais JY
  • Pierard D
  • Francois JH
  • Schneider T
  • Paxinos EE
  • Marins EG
  • Canchola JA
  • Seguin-Devaux C.

Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 Sub-Subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium.

  • HIV Clinical and Translational Research
March 26, 2019
2019 Mar. Front Microbiol.10:613.
  • Vinken L
  • Fransen K
  • Cuypers L
  • Alexiev I
  • Balotta C
  • Debaisieux L
  • Seguin-Devaux C
  • Garcia Ribas S
  • Gomes P
  • Incardona F
  • Kaiser R
  • Ruelle J
  • Sayan M
  • Paraschiv S
  • Paredes R
  • Peeters M
  • Sonnerborg A
  • Vancutsem E
  • Vandamme AM
  • Van den Wijngaert S
  • Van Ranst M
  • Verhofstede C
  • Stadler T
  • Lemey P
  • Van Laethem K.
See all publications


Carole Devaux


29, rue Henri Koch
L-4354 Esch-sur-Alzette
Tel. : +352 26970-224