The HIV Clinical and Translational Research (HIV-CTR) Group is interested in clinically oriented research in the field of resistance to antiviral therapy and transmission, as well as providing new translational knowledge on HIV cure and on HIV immunopathogenesis using humanized mouse models. The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in emerging countries (mainly in Africa) to support knowledge and technology transfer. The Group provides specialized technical support for the clinical follow-up of HIV and HCV-infected patients and is the first supplier of public health information for these infections in Luxembourg.


Research projects

  • HIV Molecular Epidemiology in Europe, the SPREAD surveillance program
  • Toxicomania, hepatitis C and substitution: epidemiological, behavioral and clinical study in Luxembourg
  • Development of heteromultimeric multifunctional therapeutic molecules activating the complement action towards target cells
  • Assessment of the sequential events driving immune activation in the gut during acute HIV infection by using an in vivo model of humanized mice
  • Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery

Featured Publications

Predominance of the heterozygous CCR5 delta-24 deletion in African individuals resistant to HIV infection might be related to a defect in CCR5 addressing at the cell surface.

  • HIV Clinical and Translational Research
  • Platform National Cytometry Platform
  • Immuno-Pharmacology and Interactomics
  • DII Custom Group 2
September 01, 2019
2019 Sep. J Int AIDS Soc.22(9):e25384.
  • Arendt V
  • Amand M
  • Iserentant G
  • Lemaire M
  • Masquelier C
  • Ndayisaba GF
  • Verhofstede C
  • Karita E
  • Allen S
  • Chevigne A
  • Schmit JC
  • Bercoff DP
  • Seguin-Devaux C.

FHR4-based immunoconjugates direct complement-dependent cytotoxicity and phagocytosis towards HER2-positive cancer cells.

  • HIV Clinical and Translational Research
  • Immuno-Pharmacology and Interactomics
  • Platform National Cytometry Platform
July 31, 2019
2019 Jul. Mol Oncol. [Epub ahead of print].
  • Seguin-Devaux C
  • Plesseria JM
  • Verschueren C
  • Masquelier C
  • Iserentant G
  • Fullana M
  • Jozsi M
  • Cohen JHM
  • Dervillez X.
See all publications


Carole Devaux


29, rue Henri Koch
L-4354 Esch-sur-Alzette
Tel. : +352 26970-224