The HIV Clinical and Translational Research (HIV-CTR) Group is interested in clinically oriented research in the field of resistance to antiviral therapy and transmission, as well as providing new translational knowledge on HIV cure and on HIV immunopathogenesis using humanized mouse models. The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in emerging countries (mainly in Africa) to support knowledge and technology transfer. The Group provides specialized technical support for the clinical follow-up of HIV and HCV-infected patients and is the first supplier of public health information for these infections in Luxembourg.


Research projects

  • HIV Molecular Epidemiology in Europe, the SPREAD surveillance program
  • Toxicomania, hepatitis C and substitution: epidemiological, behavioral and clinical study in Luxembourg
  • Development of heteromultimeric multifunctional therapeutic molecules activating the complement action towards target cells
  • Assessment of the sequential events driving immune activation in the gut during acute HIV infection by using an in vivo model of humanized mice
  • Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery

Featured Publications

Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study.

  • HIV Clinical and Translational Research
March 01, 2017
2017 Mar. Lancet Gastroenterol Hepatol.2(3):161–176. Epub 15 Dec 2016.
  • The Polaris Observatory HCV Collaborators (Arendt V Seguin-Devaux C and Struck D for Luxembourg)
  • .

Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?

  • HIV Clinical and Translational Research
December 20, 2016
2016 Dec. J Antimicrob Chemother. [Epub ahead of print].
  • Kletenkov K
  • Hoffmann D
  • Boni J
  • Yerly S
  • Aubert V
  • Schoni-Affolter F
  • Struck D
  • Verheyen J
  • Klimkait T
  • Swiss H. I. V. Cohort Study.
See all publications


Carole Devaux


29, rue Henri Koch
L-4354 Esch-sur-Alzette
Tel. : +352 26970-224