Activities

The HIV Clinical and Translational Research (HIV-CTR) Group is interested in clinically oriented research in the field of resistance to antiviral therapy and transmission, as well as providing new translational knowledge on HIV cure and on HIV immunopathogenesis using humanized mouse models. The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in emerging countries (mainly in Africa) to support knowledge and technology transfer. The Group provides specialized technical support for the clinical follow-up of HIV and HCV-infected patients and is the first supplier of public health information for these infections in Luxembourg.

Collaborations:

Research projects

  • HIV Molecular Epidemiology in Europe, the SPREAD surveillance program
  • Toxicomania, hepatitis C and substitution: epidemiological, behavioral and clinical study in Luxembourg
  • Development of heteromultimeric multifunctional therapeutic molecules activating the complement action towards target cells
  • Assessment of the sequential events driving immune activation in the gut during acute HIV infection by using an in vivo model of humanized mice
  • Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery

Featured Publications

Less cytotoxic protoflavones as antiviral agents: Protoapigenone 1′-O-isopropyl Ether shows improved selectivity against the Epstein-Barr Virus lytic cycle.

  • HIV Clinical and Translational Research
December 04, 2019
2019 Dec. Int J Mol Sci.20(24):6269.
By:
  • Vagvolgyi M
  • Girst G
  • Kusz N
  • Otvos SB
  • Fulop F
  • Hohmann J
  • Servais JY
  • Seguin-Devaux C
  • Chang FR
  • Chen MS
  • Chang LK
  • Hunyadi A.

Ensuring on-site Ebola patient monitoring and follow-up: Development of a laboratory structure embedded in an Ebola treatment center.

  • HIV Clinical and Translational Research
December 01, 2019
2019 Dec. Disaster Med Public Health Prep.13(5-6):1028-1034.
By:
  • Williams A
  • Amand M
  • Van den Bergh R
  • De Clerck H
  • Antierens A
  • Chaillet P.
See all publications

Contacts

Carole Devaux

Ph.D.

29, rue Henri Koch
L-4354 Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-224