Activities

The Bioinformatics and Modelling group’s vision is to enable benefits for patients through integrated computational and biological modeling. The main objective is to enable translationally-oriented research through strong collaborations at the LIH and abroad. This requires making sense of the large and complex datasets obtained from patients, animal and cell line models. The group’s top priority is the development of novel computational models for cancer patient stratification and drug response prediction using multi-omics data. The scientists within the group lead and enable cross-disciplinary research partnerships, which benefit from their diverse expertise in: a. Biological network modeling and analysis; c. Integrative, large-scale analysis of multi-omics data; and C. Biostatistics and machine learning.

Research projects

  • “Drug repositioning for the treatment of myocardial infarction through systems biology approaches (INFUSED)”, Luxembourg’s National Research Fund (FNR) / Swiss National Science Foundation (SNSF).
  • “Non-coding RNA regulatory circuits in glioma” (CIRCUITOMA), FNR, INTER programme.
  • “New tools for the prediction of influential nodes and links in multi-level cancer-related networks”, FNR, Luxembourg-Singapore cooperation programme, 2016-2018

Featured Publications

A DNA repair and cell cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications.

  • NORLUX-DNA repair and chemoresistance
  • Bioinformatics and Modelling
  • NORLUX-Glioma Biology
January 23, 2019
2019 Jan. Cancer Res. [Epub ahead of print].
By:
  • Gobin M
  • Nazarov PV
  • Warta R
  • Timmer M
  • Reifenberger G
  • Felsberg J
  • Vallar L
  • Chalmers AJ
  • Herold-Mende CC
  • Goldbrunner R
  • Niclou SP
  • Van Dyck E.

RNAi/CRISPR Screens: from a Pool to a Valid Hit.

  • NORLUX-Glioma Biology
  • Bioinformatics and Modelling
  • NORLUX-DNA repair and chemoresistance
January 01, 2019
2019 Jan. Trends Biotechnol.37(1):38-55. Epub 2018 Aug 31.
By:
  • Schuster A
  • Erasimus H
  • Fritah S
  • Nazarov PV
  • van Dyck E
  • Niclou SP
  • Golebiewska A.
See all publications

Contact

Francisco Azuaje

Ph.D.

1A-B, rue Thomas Edison
1445 Strassen
Luxembourg
Tel. : +352 26970-875