The Bioinformatics and Modelling group’s vision is to enable benefits for patients through integrated computational and biological modeling. The main objective is to enable translationally-oriented research through strong collaborations at the LIH and abroad. This requires making sense of the large and complex datasets obtained from patients, animal and cell line models. The group’s top priority is the development of novel computational models for cancer patient stratification and drug response prediction using multi-omics data. The scientists within the group lead and enable cross-disciplinary research partnerships, which benefit from their diverse expertise in: a. Biological network modeling and analysis; c. Integrative, large-scale analysis of multi-omics data; and C. Biostatistics and machine learning.

Research projects

  • “Drug repositioning for the treatment of myocardial infarction through systems biology approaches (INFUSED)”, Luxembourg’s National Research Fund (FNR) / Swiss National Science Foundation (SNSF).
  • “Non-coding RNA regulatory circuits in glioma” (CIRCUITOMA), FNR, INTER programme.
  • “New tools for the prediction of influential nodes and links in multi-level cancer-related networks”, FNR, Luxembourg-Singapore cooperation programme, 2016-2018

Featured Publications

Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.

  • Bioinformatics and Modelling
  • NORLUX Neuro-Oncology Laboratory
April 08, 2019
2019 Apr. Neuro Oncol. [Epub ahead of print].
  • Hossain JA
  • Latif MA
  • Ystaas LAR
  • Ninzima S
  • Riecken K
  • Muller A
  • Azuaje F
  • Joseph JV
  • Talasila KM
  • Ghimire J
  • Fehse B
  • Bjerkvig R
  • Miletic H.

Interplay between coding and exonic splicing regulatory sequences.

  • Bioinformatics and Modelling
April 08, 2019
2019 Apr. Genome Res. [Epub ahead of print].
  • Fontrodona N
  • Aube F
  • Claude JB
  • Polveche H
  • Lemaire S
  • Tranchevent LC
  • Modolo L
  • Mortreux F
  • Bourgeois C
  • Auboeuf D.
See all publications


Francisco Azuaje


1A-B, rue Thomas Edison
1445 Strassen
Tel. : +352 26970-875