Activities

The Bioinformatics and Modelling group’s vision is to enable benefits for patients through integrated computational and biological modeling. The main objective is to enable translationally-oriented research through strong collaborations at the LIH and abroad. This requires making sense of the large and complex datasets obtained from patients, animal and cell line models. The group’s top priority is the development of novel computational models for cancer patient stratification and drug response prediction using multi-omics data. The scientists within the group lead and enable cross-disciplinary research partnerships, which benefit from their diverse expertise in: a. Biological network modeling and analysis; c. Integrative, large-scale analysis of multi-omics data; and C. Biostatistics and machine learning.

Research projects

  • “Drug repositioning for the treatment of myocardial infarction through systems biology approaches (INFUSED)”, Luxembourg’s National Research Fund (FNR) / Swiss National Science Foundation (SNSF).
  • “Non-coding RNA regulatory circuits in glioma” (CIRCUITOMA), FNR, INTER programme.
  • “New tools for the prediction of influential nodes and links in multi-level cancer-related networks”, FNR, Luxembourg-Singapore cooperation programme, 2016-2018

Featured Publications

The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by alpha-PD-L1 or alpha-IL6 antibodies.

  • Bioinformatics and Modelling
  • Genomics Center
November 01, 2018
2018 Nov. J Leukoc Biol.104(5):969-985. Epub 2018 Jul 24.
By:
  • Rolvering C
  • Zimmer AD
  • Ginolhac A
  • Margue C
  • Kirchmeyer M
  • Servais F
  • Hermanns HM
  • Hergovits S
  • Nazarov PV
  • Nicot N
  • Kreis S
  • Haan S
  • Behrmann I
  • Haan C.

Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.

  • Bioinformatics and Modelling
November 01, 2018
2018 Nov. J Leukoc Biol.104(5):987-1002. Epub 2018 Aug 26.
By:
  • Kirchmeyer M
  • Servais FA
  • Hamdorf M
  • Nazarov PV
  • Ginolhac A
  • Halder R
  • Vallar L
  • Glanemann M
  • Rubie C
  • Lammert F
  • Kreis S
  • Behrmann I.
See all publications

Contact

Francisco Azuaje

Ph.D.

1A-B, rue Thomas Edison
1445 Strassen
Luxembourg
Tel. : +352 26970-875