POSTDOCTORAL FELLOW in Cancer research - AM0120

LOVIT is seeking a highly motivated Postdoctoral Fellowto work in the development of secondgeneration parvovirus based therapies in Luxembourg City. The candidatewill join a team of very motivated scientists in a stimulating environmentparticipating in a very promising established project.
1A-B, rue Thomas Edison, Strassen 1445, Luxembourg
18/02/2020 09:44:30
context of the research

Oncolytic viruses (OV) are attracting growing interest as cancer therapeutics because they specifically kill cancer cells and activate antitumor immune responses. Our research mainly focuses on oncolytic rat parvovirus H-1 (H-1PV). H-1PV is not pathogenic for humans and possesses oncolytic and oncosuppressive properties. H-1PV has been tested in a phase I/IIa trial in patients with recurrent glioblastoma, the most common and aggressive form of brain tumour in humans. Results show that virus treatment is safe, well tolerated and associated with first evidence of efficacy. However, further development is necessary to improve clinical outcome. In this project we aim (i) to construct a second generation of PV-based vectors with improved oncolytic and immunostimulatory activities (see Ref.: 1 and 2). Our ambition is to produce the necessary proof(s)-of- concept necessary to move most promising therapies from the bench into the clinic.

References

Marchini A., Daeffler L., Pozdeev V. I., Angelova A. and Rommelaere J. (2019). Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study. Front. Immunol. 10:1848. doi: 10.3389/fimmu.2019.01848.

Bretscher C. and Marchini A. (2019).  H-1 Parvovirus as a Cancer-Killing Agent: Past, Present, and Future. Viruses 2019, 11(6), 562; https://doi.org/10.3390/v11060562

KEY Accountabilities 
  • Carry out a research project independently (drafting, validation, etc.) and set up follow up projects.
  • Participate in the execution of a research project (implementation, follow-up, planning) within a research team while trying to optimize productivity.
  • Participate in the activities of the research unit and integrate into teams.
  • Design and execute experiments as required by the project.
  • Write scientific articles for peer-reviewed international journals.
  • Develop scientific methodology and techniques adapted to the research project.
  • Contribute to defining research priorities with the Director of the Department.
  • Evaluate research results for patent filing together with BDO and the Director of the Department.
  • Establish an internal and external cooperation for the implementation of new laboratory techniques.
  • Present the work as well as results during research unit meetings and at international meetings, congresses.
  • Establish and disseminate the bibliography to the other researchers, students and technicians.
  • Communicate problems and suggestions for possible solutions in a clear way.
  • Train and supervise technicians, master students and PhD students (if applicable).
  • Stay updated with the current scientific literature concerning the study.
  • Participate in the societal dimension: dissemination of simplified research results to the general public (through articles, conferences, etc.).

KEY SKILLS, EXPERIENCE AND QUALIFICATIONS
  • Doctorate’s degree in science (PhD).
  • A solid background in virology and cell biology with a great interest in oncolytic virus therapy.
  • Previous experience in at least one of the following areas: adenovirus, parvovirus, vectorology, RNAi, immunotherapy or oncolytic virus-therapy.
  • Previous experience in working with animal models of human cancers.
  • Good publication record in well recognized international journals with at least two papers in journals with an impact factor higher than five.
  • Languages skills: fluent command of English, knowledge of another language of the European Union is an asset.

REF.: CM/PDF0120/AM/LOVIT
Fixed-term contract until end of December 2020, full time, start date asap, possible extension

Contacts

Department of Oncology

Dr. Antonio Marchini (LOVIT Unit)

Antonio.Marchini@lih.lu

a.marchini@dkfz.de