Post-doctoral Researcher in Proteomics - GD0717

Luxembourg Institute of Health
1A-B, rue Thomas Edison, Strassen 1445, Luxembourg
Context of the research

Deregulated signaling of receptor tyrosine kinases (RTK) are a hallmark of glioblastomas (GBM) and many therapeutic attempts are undertaken to interfere with hyperactive intracellular signaling. Attempts to map the exact phosphorylation status of the RTK substrates is hampered by complicated phosphorylation pattern. By combining the extensive expertise in both Mass Spectrometry and GBM Biology at the Luxembourg Institute of Health, this project aims to characterize and quantify phospho-sites involved in GBM cell signaling with superior level of accuracy.

The proteomics laboratory is equipped with the latest instrumentation in high-resolution mass spectrometry. Close collaborations with the other groups of the LIH offer a wide spectrum of modern techniques. Especially the close collaborations of the proteomics laboratory with the bioinformatics group allows the rapid development of specialized techniques and tools to address specific scientific challenges
KEY SKILLS, EXPERIENCE AND QUALIFICATIONS
  • Solid knowledge about mass spectrometry based proteomics
  • Identification of post-translational modifications
  • Targeted proteomics
  • Use of the Skyline software package
  • Use of the MaxQuant software package
  • Demonstrable capacity to perform multiple research tasks under time and resource constraints 

  • Knowledge about biological signaling cascades
  • Fluency in English is mandatory (English is the working language)

More information regarding the unit can be found here : www.lih.lu/dittmar

Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with the university and other research institutes.

REF.: vd/PDR0717/GD/GENPRO
2 year fixed-term contract, full time, start date : immediate

Contacts

For scientific questions:
Dr. Gunnar Dittmar (Proteome and Genome Research Unit)
Gunnar.dittmar@lih.lu