PhD Student position in Cellular and Molecular Biology - Nextimmune DTU - JS0218- LCSB

NEXTIMMUNE, standing for “Next Generation ImmunoScience: Advanced Concepts for Deciphering Acute and Chronic Inflammation”, is a competitive PhD training program, supported by the doctoral research funding scheme PRIDE of the Luxembourg National Research Fund FNR. It aims to bridge classical immunology and big-data analysis science in a structured doctoral training environment.
29, rue Henri Koch, Esch-sur-Alzette L-4354, Luxembourg
29/01/2019 14:19:32

With up to 4 years fixed-term contract, full-time. Start date flexible from now on until July 2019. Supervisor: Prof. Dr. Jochen Schneider, Translational and Experimental Medicine (TEM) group at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg.


Project : Role of IRG-1 in inflammatory vascular diseases

Research keywords: Immune response gene 1, itaconic acid, Atherosclerosis, metabolism, inflammation

Cutting edge: defining a novel player as potential target mechanism for inflammatory vascular diseases

Collaborations: Dr. Johannes Meiser (LIH), Dr. Alessandro Michelucci (LIH), Dr . Alex Skupin (LCSB)


Inflammatory vascular disease such as atherosclerosis or  vascular inflammation affect a large number of subjects of the world population. Since vascular diseases represents a lipid-driven inflammation the pathophysiology requires a wiring of metabolism and immune system.  IRG1 is a macrophage specific gene characteristic for immune system activation and is induced by bacterial stimuli as well as oxLDL. The IRG-1 dependent production of the substrate itaconic acid (ITA) directly interferes with cellular tricarboxylic cycle (TCA) metabolism. IRG-1 also mediates the production of reactive oxygen species (ROS) in macrophages. These data suggest that IRG-1 links innate immune activation with metabolism. We aim to characterize the role if IRG-1 in inflammatory vascular disease in vivo and in vitro. This project aims at defining a novel player as potential target mechanism for inflammatory processes in the vasculature.


Requirements of the ideal candidate:

·         Master degree in biology,  life sciences or a related discipline.

·         Strong wet laboratory and analytical skills.

·         Prior experience in molecular biology tools is desired.

·         Experience with cell culture techniques and animal handling is required.

·         Excellent working knowledge of English.

 

We offer:

·         Opportunity to do applied research of clinical relevance within a highly dynamic research institution (LCSB) and in collaboration with internationally recognized partners.

·         An exciting international environment.

·         A very competitive salary

         Applications including a motivation letter describing past research experience and future interests, at least two confidential references letters, a full curriculum vitae and a copy of the relevant diplomas showing marks should be sent via the Apply button ONLY  - Ref: VD/PHDNI0218/MO/LCSB-DII before 30 June 2019. Only complete applications will be considered


REF.: VD/PHDNI0218/MO/LCSB-DII-JS

Contacts

More specific information on NEXTIMMUNE can be obtained from the program coordinator, Prof Markus Ollert, Director of LIH’s Department of Infection and Immunity: nextimmune.office@lih.lu. For more information on the Research Project, please contact Prof. Dr. Jochen Schneider : jochen.schneider@uni.lu