PhD Student position in Cellular and Molecular Biology - Nextimmune DTU - JS0218- LCSB

NEXTIMMUNE, standing for “Next Generation ImmunoScience: Advanced Concepts for Deciphering Acute and Chronic Inflammation”, is a competitive PhD training program, supported by the doctoral research funding scheme PRIDE of the Luxembourg National Research Fund FNR. It aims to bridge classical immunology and big-data analysis science in a structured doctoral training environment.
29, rue Henri Koch, Esch-sur-Alzette L-4354, Luxembourg
08/02/2018 11:41:55

With up to 4 years fixed-term contract, full-time. Start date flexible from now on until July 2018. Supervisor: Prof. Dr. Jochen Schneider, Translational and Experimental Medicine (TEM) group at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg.

The research-intensive program aims to respond to the unmet need of training the next generation of competent immunologists by tackling next generation immunology challenges from wet lab procedures to big data analyses. We offer an interdisciplinary environment that covers analysis of “omics” and clinical data, as well as basic and translational biomedical knowledge combined with its practical application to diagnosis and ultimately therapy. The program includes transferable skills training, support in career development, scientific lectures by international speakers and annual PhD retreats.

The Luxembourg Centre for Systems Biomedicine (LCSB) was created within the Health Technologies Initiative from the Government of Luxembourg as one of the research priorities of the University of Luxembourg. The LCSB is an Interdisciplinary Centre of the University, independent of the faculties and it combines experimental and computational approaches to analyse complex biological systems and disease processes from a systems biology perspective. The TEM group aims to perform interdisciplinary discovery research in the medical context and to translate basic research into clinically relevant information.

The TEM group is seeking a highly skilled and motivated Ph.D. student to work on an exciting project aiming at the understanding and elucidation of mechanisms underlying mast cell differentiation and functions.  Mast cells act as effectors in allergic reactions. The mast cell physiology and function mainly depend on cell-cell and cell-matix interactions mediated by integrin family of adhesion molecules. This project aims at defining a novel player as potential target mechanism for mast cell functionality/allergy interference as well as other mast cell-related diseases. In particular, the selected candidate shall use techniques of molecular biology such Western blots, Polymerase chain reaction (PCR), microarrays, ELISA and other biochemical methods to understand the involved signalling pathways.  The candidate will use in-vitro cell culture techniques and in-vivo animal models  in the mechanistic studies of the mast cell functions.

Requirements of the ideal candidate:

·         Master degree in biology,  life sciences or a related discipline.

·         Strong wet laboratory and analytical skills.

·         Prior experience in molecular biology tools is desired.

·         Experience with cell culture techniques and animal handling is required.

·         Excellent working knowledge of English.


We offer:

·         Opportunity to do applied research of clinical relevance within a highly dynamic research institution (LCSB) and in collaboration with internationally recognized partners.

·         An exciting international environment.

·         A very competitive salary

         Applications including a motivation letter describing past research experience and future interests, at least two confidential references letters, a full curriculum vitae and a copy of the relevant diplomas showing marks should be sent via the Apply button ONLY  - Ref: VD/PHDNI0218/MO/LCSB-DII before 1 May 2018. Only complete applications will be considered



More specific information on NEXTIMMUNE can be obtained from the program coordinator, Prof Markus Ollert, Director of LIH’s Department of Infection and Immunity: For more information on the Research Project, please contact Prof. Dr. Jochen Schneider :