PhD Student position in Cellular and Molecular Biology - Nextimmune DTU - JS0218- LCSB
29, rue Henri Koch, Esch-sur-Alzette L-4354, Luxembourg
With up to 4 years fixed-term contract, full-time. Start date flexible from now on until July 2019. Supervisor: Prof. Dr. Jochen Schneider, Translational and Experimental Medicine (TEM) group at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg.
Project : Role of IRG-1 in inflammatory vascular diseases
Research keywords: Immune response gene 1, itaconic acid, Atherosclerosis, metabolism, inflammation
Cutting edge: defining a novel player as potential target mechanism for inflammatory vascular diseases
Collaborations: Dr. Johannes Meiser (LIH), Dr. Alessandro Michelucci (LIH), Dr . Alex Skupin (LCSB)
Inflammatory vascular disease such as atherosclerosis or vascular inflammation affect a large number of subjects of the world population. Since vascular diseases represents a lipid-driven inflammation the pathophysiology requires a wiring of metabolism and immune system. IRG1 is a macrophage specific gene characteristic for immune system activation and is induced by bacterial stimuli as well as oxLDL. The IRG-1 dependent production of the substrate itaconic acid (ITA) directly interferes with cellular tricarboxylic cycle (TCA) metabolism. IRG-1 also mediates the production of reactive oxygen species (ROS) in macrophages. These data suggest that IRG-1 links innate immune activation with metabolism. We aim to characterize the role if IRG-1 in inflammatory vascular disease in vivo and in vitro. This project aims at defining a novel player as potential target mechanism for inflammatory processes in the vasculature.
Requirements of the ideal candidate:
· Master degree in biology, life sciences or a related discipline.
· Strong wet laboratory and analytical skills.
· Prior experience in molecular biology tools is desired.
· Experience with cell culture techniques and animal handling is required.
· Excellent working knowledge of English.
· Opportunity to do applied research of clinical relevance within a highly dynamic research institution (LCSB) and in collaboration with internationally recognized partners.
· An exciting international environment.
· A very competitive salary
Applications including a motivation letter describing past research experience and future interests, at least two confidential references letters, a full curriculum vitae and a copy of the relevant diplomas showing marks should be sent via the Apply button ONLY - Ref: VD/PHDNI0218/MO/LCSB-DII before 30 June 2019. Only complete applications will be considered