PhD Student in Stem Cell Research - YD0119
1A-B, rue Thomas Edison, Strassen 1445, Luxembourg
Stem cells have the potential to be used to stimulate organ regeneration after injury and to cope with the inability of certain human organs to regenerate. Long noncoding RNAs constitute a large part of the RNA molecules that are transcribed from our genes and, even though they are unable to be translated into proteins like messenger RNAs, they possess a wide variety of transcriptional regulation properties. Past studies in the lab allowed the identification of several long noncoding RNAs associated with tissue regeneration.
During his/her PhD, the applicant will
study the role of previously identified long noncoding RNAs in tissue
regeneration. The experiments will involve in vitro mechanistic investigations
in induced pluripotent stem cells, using gain- and loss-of-function strategies.
Different end-points such as cell proliferation, survival, apoptosis, as wells
as different aspects of cell function will be studied. The utility of long
noncoding RNAs as biomarkers will be investigated using human blood samples.
Bioinformatics analytical pipelines will be deployed to predict functional
roles of long noncoding RNAs.
KEY SKILLS, EXPERIENCE AND QUALIFICATIONS
- Master’s degree (or equivalent) in Molecular and Cellular Biology, Genetics or a related biomedical field. Prior experience in induced pluripotent stem cells would be an advantage, but is not mandatory.
- Good communication would be necessary to deal with the different partners involved in this project, as well as for restitution of the results
- Excellent time management, rigour, perseverance, scientific creativity and originality, writing skills, conciseness, sense of priority and ability to work with others.
- IT skills: Office, Outlook.
- Fluency in English, French would be an asset.
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with the university and other research institutes
Applications including a cover letter and a curriculum vitae should be sent before 28 February 2019 through our website www.lih.lu/jobs. Ref.: VD/PHDSC0119/YD/CVRU
3 year fixed-term contract (can be extended to 4 years) - Full time - Start-date : ASAP after acceptation of the grant by the FNR
More information about the research group can be found here: : https://www.lih.lu/page/departments/cvru-cardiovascular-research-unit-786