PhD student in Immuno-Oncology - AM1120

To be part of the Neuro-Immunology Group (Head: Dr. A. Michelucci) within the Department of Oncolgy at the LIH, we are currently looking for a PhD student.
1A-B, rue Thomas Edison, Strassen 1445, Luxembourg
13/11/2020 09:24:01
BAckground

Gliomas represent approximately 80% of all malignant tumours of the central nervous system. Among them, Glioblastoma (GBM) is the highest-grade glioma and the most common malignant brain tumour in adults. Despite established standard care of treatment, GBM recurrence is inevitable and prognosis remains poor with a median survival of 15 months after diagnosis. Hence, the development of novel therapeutic options, including immunotherapies, are needed. Importantly, GBM is a highly immunosuppressive cancer, where tumour-associated microglia/macrophages can constitute up to 30-40% of the tumour mass playing a key role in immune escape mechanisms. Thus, targeting these cells is emerging as a promising strategy for immunotherapy.

OBJECTIVE

We aim to understand the role of tumour-associated microglia/macrophages along GBM progression with the goal to identify new prognostic markers and therapeutic targets.

Training and research Environment

The Neuro-Immunology Group belongs to the Department of Oncology, whose research activities focus on the cellular and molecular mechanisms of tumour progression using a wide range of cutting edge technologies, including genomics, transcriptomics and proteomics analyses, as well as in vitro and in vivo imaging modalities using both patient cohorts and state-of-the-art animal models for cancer research. The PhD student will be in charge of an Action LIONS funded project that aims to uncover targets to shift immune-suppressed TAMs into reactive cells in Glioblastoma.

KEY SKILLS, EXPERIENCE AND QUALIFICATIONS
  • Master’s degree in Biomedical Sciences or Immunology. Prior experience in cancer research would be an advantage, but is not mandatory.
  • Experience in cell culture, transcriptomics (scRNA-seq), confocal microscopy and flow-cytometry techniques.
    Mouse experimentation practice and FELASA diploma (or equivalent) would be considered as an asset.
  • Excellent time management, rigour, perseverance, scientific creativity and originality, writing skills,  sense of priority and ability to work with others.
  • Fluency in English is mandatory.

REF.: VD/PHDIO1120/AM/NIG
3-year fixed-term contract (renewable for 1 year) - Full time - Start date: January/February 2021

Contacts

Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with universities and other research institutes.

 

Scientific contact

Dr. Alessandro Michelucci, PhD

84 Val Fleuri

L-1526 Luxembourg

LUXEMBOURG

Additional information on the group can be found here : https://nig.lih.lu