PhD Student in Cardiovascular Research - YD1217
1A-B, rue Thomas Edison, Strassen 1445, Luxembourg
The project aims to identify novel RNA biomarkers that can be used to predict neurological outcome and survival after cardiac arrest. Cardiac arrest is a main health issue affecting 400,000 persons per year in Europe and 400 in Luxembourg.
Despite modern health care strategies, half of patients successfully resuscitated from out of hospital cardiac arrest suffer severe and irreversible damage of the brain and die within few days. Even though the need for a personalized healthcare system is recognized, personalized medicine is still far from being widely implemented. In the context of cardiac arrest, the implementation of personalized healthcare is limited by a lack of specific prognostication strategies. The present project aims to tackle this unmet clinical need and will focus on the discovery and validation of novel RNA biomarkers. Past investigations from the Cardiovascular Research Unit allowed to identify microRNAs in cardiac arrest patients (PMIDs 22890253; 25886727; 27438111; 28819446; 29159560). Here, the aim is to extend these research activities to the longer arm of the non-coding RNA family, i.e. long non-coding RNAs and circular RNAs.
Methodologies will include deep RNA sequencing, quantitative PCR, molecular biology, biochemistry, bioinformatics and biostatistics. One national and two international multicenter cohorts of patients with cardiac arrest are available for the project.
More information about the Unit can be found here : Cardiovascular Research Unit
purpose of the position- Participate in the setting-up of a research project.
- Carry out and finalize a research project by writing a PhD thesis in the view of obtaining a PhD degree.
- Publish her/his results in scientific journals and/or file patents if applicable.
- Disseminate her/his results to the scientific community and the general public.
- Basic knowledge of molecular biology, cardiovascular pathology, bioinformatics, and/or biostatistics is required.
- Excellent time management, rigor, perseverance, scientific creativity and originality, writing skills, conciseness,
sense of priority and ability to work with others.
- IT skills: Office, Outlook, Endnote.
- Languages skills: fluent command of English, knowledge of another language of the European Union (e.g.french) is
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with the university and other research institutes.