Internship in Cancer Research (Master2 student)- DPB1018
29, rue Henri Koch, Esch-sur-Alzette L-4354, Luxembourg
Background. Telomeres cap chromosomal ends and protect them from being detected as DNA double stranded breaks leading to apoptosis. Telomeres shorten with each cell division. Shortening of chromosomal ends therefore acts as a molecular clock, ensuring a finite number of cell divisions, after which cells become replicatively senescent and die. Telomere length aberrations are critical in many cancers, inflammatory, aging, bone marrow, lung and renal conditions. Cancer cells circumvent senescence by selectively maintaining telomere length. Telomeres are added to chromosomal ends by Telomerase and more specifically by its catalytic subunit hTERT. hTERT is silent in most somatic cells but is reactivated in 75-90% of cancers and in chronic inflammatory conditions.
Objectives. Our team focuses on the mechanisms of hTERT reactivation and on its anti-apoptotic functions in cancers (Glioblastoma Multiforme and Melanoma) and chronic inflammatory diseases, with the goal to identify new prognostic markers and therapeutic targets.
and research environment. The Innate Cellular
Immunity and Chronic Inflammation group comprises 4 small research teams
investigating the relationships between inflammation and cancer (GBM). The team
is multinational and its current members come from France, Germany, Italy,
Luxembourg and India. It belongs to the whose research activities focus on the cellular and molecular effectors the immune response in inflammation, allergy, cancer and viral infections. The project involves a wide range of molecular, cellular, imaging and biochemical technologies. The Masters student will be surpervised by Dr D. Perez Bercoff and be assisted by a PhD student.
What we offer and conditions
· Students will have the opportunity to work in an interactive and international scientific environment, attend conferences by eminent scientists from abroad, and present their own work during department meetings.
· They will receive training in basic biochemistry, molecular and cell biology techniques, such as Cloning, Western-blotting, ChIP, real-time PCR, and cell culture, as well as flow cytometry and confocal imaging.
· Applicants must be affiliated to their own University. English is mandatory.
· Master students will receive 500€/month unless they have their own funding source, e.g. Erasmus grant.
REF.: VD/M2INT1018/DPB/DII ALL3
Available for 6 months Jan-June 2019 (Can be adjusted according to the specific requirements of the University)
Dr. Danielle PEREZ BERCOFF, PhD
29 rue Henri Koch
Tel: 00352 26 970 318
More information about the group can be found here :