2 Luxemb.-RIKEN Postdoctral Fellows. in Immunology and Single-cell transcriptomic analysis - MO0818

29, rue Henri Koch, Esch-sur-Alzette L-4354, Luxembourg
21/01/2019 09:53:41

                Regulatory T cell responses at the crossroads of immune homeostasis and inflammation in the context of barrier diseases” (TregBar) is a research project funded by the Luxembourg National Research Fund`s (FNR) bilateral AFR funding instrument. One of the major goals of this program is to initiate long-term collaborations with the RIKEN Center for Integrative Medical Sciences (IMS) (Yokohama, Japan). With the Japanese partner RIKEN-IMS, TregBar utilizes the joint forces from the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) (Esch-sur-Alzette, Luxembourg), the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg (Belval, Luxembourg), the Department of Dermatology and Allergy Centre of the University of Southern Denmark (Odense, Denmark), and the Department of Dermatology, Universitair Ziekenhuis, Vrije Universiteit Brussels (Brussels, Belgium).

                TregBar will investigate functional gene regulatory and signaling networks of regulatory T cells (Tregs) in the context of several barrier diseases by using various murine and human disease models. For this purpose, we will combine expertise in basic immunology especially on Tregs, microbiome, single cell analysis, clinical immunology, deep immune phenotyping and computational network analysis.

                TregBar will provide the suitable candidates with the opportunity to build up a state-of-the-art research career in a competitive and international environment to tackle next-generation immunology challenges, from wet-lab procedures to handling of big data. The successful applicants will conduct their research projects at the Department of Infection and Immunity at LIH (Esch-sur-Alzette), at the LCSB, and at RIKEN-IMS (Yokohama, Japan), where they are expected to spend between 20% and 50% of the project duration. An initial two-year contract would be provided. Additionally excellent researchers will subsequently be given the opportunity to submit further funding applications.

                Luxembourg-RIKEN Postdoc Fellowship in Immunology


                The candidate will focus on the experimental aspect of the project related to Treg single-cell ‘Omics’ analysis on inflammatory skin diseases like atopic dermatitis or psoriasis mainly using patients’ materials and also contribute to other related projects within TregBar.

                 Expected Profile:  

                • A PhD in Immunology, Cell Biology or Molecular Biology, or equivalent qualifications.
                • At least one peer-reviewed publication as  a major author in the field of Immunology.
                • Training in immunological methods (especially FACS), molecular biology and cell culture techniques.
                • Strong knowledge and interest in T cell biology.
                • Experience in handling mice and infectious and/or autoimmune disease models will be considered an asset.
                • Excellent working knowledge of English.


                While being expected to closely interact with other TregBar partners, the candidate will be mainly hosted by the group of Dr. Feng He (feng.he@lih.lu) within the Department of Infection and Immunity.

                Luxembourg-RIKEN Postdoc Fellowship in Single-cell transcriptomic analysis


                The successful candidate will work in strong collaboration with different groups and perform single cell transcriptomics analysis using our established DropSeq pipeline and Fluidigm platform to investigate underlying molecular mechanisms of the immune system.

                 Expected Profile:  

                • PhD degree in biology, biotechnology, chemistry, physics, medicine or in related science
                • Experience in molecular biology including transcription analysis and/or immunology
                • Experience in microfluidics based approaches would be beneficial but not mendatory
                • Background in computational biology and/or R scripting is an additional plus
                • Critical thinking and collaborative skills


                While being expected to closely interact with other TregBar partners, the candidate will be mainly hosted by the group of Dr. Alexander Skupin (alexander.skupin@uni.lu) within the LCSB.


                Fluency in English is mandatory – English is the working language.

                Applications (in English) including a cover letter expressing your interest and the benefit of your contribution to the research field, a detailed curriculum vitae and the names of at least three referees with contact details should be sent before 30 March 2019 through our website www.lih.lu/jobs, ref: VD/PDRiken0818/MO/DII ONLY. Positions are available immediately and the reviewing of applications will start right away.

                REF.: VD/PDRiken0818/MO/DII
                2-year fixed-term contract - Full time - Start date: immediate


                For obtaining specific information on TregBar please contact the coordinators of the program, Prof. Markus Ollert, Director of the LIH Department of Infection and Immunity, or Prof. Rudi Balling, Director of the LCSB, via email: TregBar.office@lih.lu