2 Internship Positions in Cancer Research (Master students) - CT0818

Metastasis is the primarycause of death from cancer. An early and critical step of the metastaticcascade is the acquisition by tumor cells of the ability to remodel theextracellular matrix (ECM) and migrate through the stromal environment andtissue barriers. In addition, tumor cells become resistant to immune effectorcells. Both invasion and immune resistance mechanisms involve cytoskeletalchanges. Our team focuses on actin regulatory proteins and related signalingpathways driving these two key facets of tumor metastasis, with the goal toidentify new prognostic markers and therapeutic targets.
84, rue Val Fleuri, Luxembourg L-1526, Luxembourg
16/10/2018 15:18:23

Training and research environment: Cytoskeleton and Cancer Progression is a dynamic and multinational team. It belongs to the Department of Oncology, whose research activities focus on the cellular and molecular mechanisms of tumor progression using a wide range of cutting edge technologies, including genomic, transcriptomic and proteomic analyses, as well as in vitro and in vivo imaging modalities using state-of-the art animal models for cancer research. Master students will assist one of our projects that aims to explore actin-based mechanisms promoting tumor cell invasion and immune resistance and will be co-supervised by Dr. C Thomas (PI) and another experienced researcher from the team.

References:

Al Absi, A., Wurzer, H., Guerin C., Celine Hoffmann, Hoffmann, C., Moreau, F., Mao, X., Brown-Clay, J., Petrolli R., Pou Casellas C., Dieterle, M., Thiery, J.P., Chouaib, S., Berchem G., Janji B., and Thomas C. (2018). Actin cytoskeleton remodeling drives breast cancer cell escape from natural killer cell lysis. Cancer Research, accepted for publication.

Hoffmann, C., Mao, X., Brown-Clay, J., Al Absi, A., Wurzer, H., Sousa, B., Schmitt, F., Berchem, G., Janji, B., et al. (2018). Hypoxia promotes breast cancer cell invasion through HIF-1alpha-mediated up-regulation of the invadopodial actin bundling protein CSRP2. Scientific reports 8, 10191.

Hoffmann, C., Mao, X., Dieterle, M., Moreau, F., Al Absi, A., Steinmetz, A., Oudin, A., Berchem, G., Janji, B., and Thomas, C. (2016). CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis. Oncotarget 7, 13688-13705.


What we offer and conditions
  • Students will have the opportunity to work in an interactive and international scientific environment, attend conferences by eminent scientists from abroad, and present their own work during lab meetings.
  • They will receive training in basic biochemistry, molecular and cell biology techniques, such as subcloning, recombinant protein expression and purification, cell culture, and cell migration/invasion assays, as well as in state-of-the imaging approaches, such as confocal and TIRF microscopy, and imaging flow cytometry, with the objective of exploring actin cytoskeleton
  • organization and dynamics in metastatic and immune-resistant tumor cells.
  • Applicants must be affiliated to their own University. English is mandatory.
  • Master students will receive 500€/month unless they have their own funding source, e.g. Erasmus grant.

REF: CM/ICRM0718/CT/LECR
Available for 6 months (2018/2019) but can be adjusted according to the specific requirements of the Universities

Contacts

Scientific contact

Dr. Clément THOMAS, PhD (HDR)

Luxembourg Institute of Health, 84 Val Fleuri

Laboratory of Experimental Cancer Research

L-1526 Luxembourg, Luxembourg

Tel: 00352 26970252