Our jobs

Have a look at our open positions, or send us a spontaneous application !

Within the Luxembourg Institute of Health, qualified professionals with various expertises are working together striving for excellence. Physicians, biological scientists, engineers, laboratory technicians, research nurses, statisticians, bioinformatic specialists, datamanagers, accountants... are among the many professions represented in our research departments and support services units.

Their talent, their ability to collaborate and the complementarity of their skills are some of the key elements allowing us to create societal and economical value.

Are you ready to bring your talent at the service of biomedical research?

  • Postdoctoral Fellow in Tumor Immune Evasion - CT0320

    CCP - Cytoskeleton and Cancer Progression

    Immune evasion is a hallmark of cancer progression and represents a major hurdle to the design of effective therapeutic strategies. We recently uncovered a widely conserved mechanism by which resistant tumor cells respond to immune effector cell attack. The ACTIVASION project aims at exploring how this mechanism (i.e. fast remodeling of the tumor cell actin cytoskeleton) alters the structure and the function of the immunological synapse, the cell-cell interaction interface used by immune cells to recognize and kill target cancer cells.
    84, rue Val Fleuri, Luxembourg L-1526, Luxembourg
    20/03/2020 18:13:13
  • POSTDOCTORAL FELLOW in Cancer Invasion Research - CT0120

    CCP - Cytoskeleton and Cancer Progression

    Invadopodia are actin-rich membrane protrusions that facilitate tumor cell invasion through dense extracellular matrix (ECM) by recruiting transmembrane and secreted metalloproteinases (MMPs) able to catalyze ECM component degradation, and creating pores through which mesenchymal tumor cells can migrate. We recently identified CRP2 (cysteine- and glycine-rich protein 2) as a critical, cytoskeletal component of invadopodia (Hoffmann et al. 2016 Oncotarget 7: 13688-13705; Hoffmann et al. 2018 Scientific Reports 8: 10191). From a mechanistic standpoint, we found that CRP2 promotes invadopodia formation and elongation by stabilizing their actin core, which serves as a backbone of the structure. In addition, CRP2 shuttles to the nucleus where it drives expression of pro-metastatic genes, including several members of the matrix metalloproteinase (MMP) family involved in ECM remodeling and which are associated with cancer cell invasion and metastasis (Brown-Clay et al. in revision).
    84, rue Val Fleuri, Luxembourg L-1526, Luxembourg
    17/01/2020 14:12:08