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Within the Luxembourg Institute of Health, qualified professionals with various expertises are working together striving for excellence. Physicians, biological scientists, engineers, laboratory technicians, research nurses, statisticians, bioinformatic specialists, datamanagers, accountants... are among the many professions represented in our research departments and support services units.

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  • POSTDOCTORAL FELLOW in Cancer Invasion Research - CT0120

    CCP - Cytoskeleton and Cancer Progression

    Invadopodia are actin-rich membrane protrusions that facilitate tumor cell invasion through dense extracellular matrix (ECM) by recruiting transmembrane and secreted metalloproteinases (MMPs) able to catalyze ECM component degradation, and creating pores through which mesenchymal tumor cells can migrate. We recently identified CRP2 (cysteine- and glycine-rich protein 2) as a critical, cytoskeletal component of invadopodia (Hoffmann et al. 2016 Oncotarget 7: 13688-13705; Hoffmann et al. 2018 Scientific Reports 8: 10191). From a mechanistic standpoint, we found that CRP2 promotes invadopodia formation and elongation by stabilizing their actin core, which serves as a backbone of the structure. In addition, CRP2 shuttles to the nucleus where it drives expression of pro-metastatic genes, including several members of the matrix metalloproteinase (MMP) family involved in ECM remodeling and which are associated with cancer cell invasion and metastasis (Brown-Clay et al. in revision).
    84, rue Val Fleuri, Luxembourg L-1526, Luxembourg
    17/01/2020 14:12:08