WEBINAR: Lecture series Cancer Research: "Targeting DNA repair: from basic biology to clinical trials"- Prof Thomas Helleday
26/11/2020 11:00 to 26/11/2020 12:15 (Europe/Luxembourg)
DNA damaging agents, i.e., radio- and chemotherapy, constitute the backbone for treatment of a wide variety of cancers and may result in complete cure from the disease. Here, I will give an overview on how DNA repair can be targeted using completely novel inhibitors and more speciﬁcally how cancer cells may require a speciﬁc DNA repair pathway to mediate survival to the high load of endogenous DNA damage. DNA repair inhibitors can be exploited in treatment of mutated cancers and here, I will present our pioneering work on using PARP inhibitors to selectively kill homologous recombination defective cancers and how this has been translated into the clinic. Furthermore, I will cover how to we identify novel targets using CRISPR-Cas9 and the difﬁculties of that approach. Novel targets emerging from our laboratory such as MTHFD° will be discussed in detail and the strategies to advance these as anti-cancer treatments in a precision medicine approach. Finally, I will discuss the complication of targeting DNA repair proteins with many functions.
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About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Lectures will be organised, followed by workshops especially dedicated to early-stage researchers. Please find here the programme for 2020.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.