Lecture series Translational Bioinformatics and Systems Biomedicine "IDENTIFYING DRUGGABLE GENETIC DEPENDENCIES FOR PERSONALIZED CANCER THERAPY" - Dr Fatima Al-Shahrour

21/03/2019 16:30 to 21/03/2019 18:15 (Europe/Luxembourg)

Esch-sur-Alzette, Luxembourg

Speaker

Dr Fatima Al-Shahrour is Head of Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

 

Abstract

The paradigm of personalized medicine is the identification of the appropriate drug for the right patient, using molecular profiles. In Oncology, it is well established that the anticancer drugs are effective in only a small subset of patients. Moreover, many of the new targeted therapies inhibit specific proteins, and they are only effective in tumors that are genetically altered. Consequently, the success of personalized treatment depends on each individual molecular profile, which a priori can be considered as very heterogeneous.  Here, we present new computational approaches based on the analysis and integration of genomic data (mutations, copy number variations or gene expression levels), with functional data (protein essentiality) and pharmacological data. These methods aim to identify those vulnerable molecular alterations that drive tumor progression and could be druggable based on the patient’s molecular profile, and propose an individualized therapeutic strategy to guide clinical decision making for cancer patients.

https://bioinformatics.cnio.es

https://www.pandrugs.org

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schedule

16.30 - 17.30: LECTURE

University of Luxembourg

Maison des Sciences Humaines

Blackbox room

17.30 - 18.15: 'meet THE SPEAKER'

University of Luxembourg

Maison des Sciences Humaines

Room N°0.205


Registration required for the 'Meet the Speaker' - send us an email

programme 2019

About the Lecture & Workshop series - TRANSLATIONAL BIOINFORMATICS AND SYSTEMS BIOMEDICINE

The LIH lecture and workshops series in Translational Bioinformatics and Systems Biomedicine, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Translational Bioinformatics and Systems Biomedicine.  Please find here  the current programme for 2019.

This lecture will be followed by a workshop especially dedicated to early-stage researchers.

Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.

Where

Maison des Sciences Humaines
    11, Porte des Sciences
    Esch-sur-Alzette L-4362
    Luxembourg

When

From 21/03/2019 16:30
To 21/03/2019 18:15

Contact

Luxembourg Institute of Health
odoo@lih.lu