Lecture series Infection & Immunity: "THE T CELL - PHAGOCYTE INTERFACE IN TISSUE" - Prof Burkhard Becher
14/03/2019 11:00 to 14/03/2019 14:00 (Europe/Luxembourg)
Whereas T cells are generally thought of as mediators of tissue damage in chronic tissue inflammation, the cellular infiltrate is always dominated by myeloid cells. The granulocyte- macrophage colony-stimulating factor (GMCSF) was initially classified as a hematopoietic growth factor. However, unlike its close relatives macrophage CSF (M-CSF) and granulocyte CSF (G-CSF), the majority of myeloid cells do not require GMCSF for steady-state myelopoiesis. Instead, in inflammation, GM-CSF serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. Even though lymphocytes are in all likelihood the instigators of chronic inflammatory disease, GM-CSF-activated phagocytes are well equipped to cause tissue damage. The pivotal role of GM-CSF at the T cell: myeloid cell interface might shift our attention toward studying the function of the myeloid compartment in immunopathology and targeting specifically the crosstalk between T cells and myeloid cells through GM-CSF holds promise for the development of therapeutics to combat chronic tissue inflammation. I will discuss how GM-CSF licenses phagocytes to initiate tissue damage in chronic inflammatory diseases.
11:00 - 12:00 : LECTURE
Lycée Guillaume Kroll Salle de projection audiovisuelle
12:30 - 14:00 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2019, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2019.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.