Lecture Series "Infection & Immunity" - Prof Sylviane Muller - "Peptide-based treatment of auto-inflammatory diseases"

01/02/2018 11:00 to 01/02/2018 14:00 (Europe/Luxembourg)

Esch/Alzette, Luxembourg

Speaker

Prof Sylviane MULLER is Distinguished Class CNRS Director, Professor University of Strasbourg Institute for Advanced Study / Chair Therapeutic Immunology, Director of the CNRS Institut de Biologie Moléculaire et Cellulaire (IBMC), Director of the CNRS laboratory Immunopathology and therapeutic chemistry, Head of the Laboratory of Excellence Drug Discovery Center Medalis.

ABSTRACT

Since several years, I have concentrated my activity on systemic lupus erythematosus (SLE), which represents a prototype of autoimmune rheumatic disease. SLE is characterized by inflammation and damage to various tissues, complement deficiencies, modification of cytokine secretion and production of autoantibodies. At least 100 different antigens, often nuclear, targeted by specific antibodies have been characterized in SLE. The cause of the illness is poorly understood, multifactorial in essence, depending on risk factors that are genetic, hormonal (with a female prevalence) and environmental. Over the recent years, I have focused my research activity on the pathways involved in autoreactive lymphocytes activation and on molecular events leading to cell death/living phenomena (apoptosis, autophagy) that are central in lupus. Combining my fundamental knowledge of lupus with my long lasting experience in peptide chemistry has enabled me, with my team, to develop very novel strategies to modulate the aberrant immune response and restore normal immune functions using synthetic peptides. The results of a Phase IIb clinical trial directed by ImmuPharma including one of our peptides in ~150 lupus patients gave extremely promising results. This peptide is currently evaluated in a phase III clinical trial both in the US and Europe (LUPUZOR program). More recently, I have been involved in studies dealing with neuropsyschiatric lupus with the objective to better understand the molecular basis of this dramatic form of lupus and propose specific strategies to treat affected patients. My approaches are based on fundamental immunology, immunochemistry, cellular and molecular biology, biochemistry, organic chemistry and pharmacology, structure-function studies, chemoinformatics, physiology, cellular imaging and manipulation of animal models.

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SCHEDULE

11:00 - 12:00 : LECTURE

Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle

12:30 - 14:00 : 'meet & eat'

House of BioHealth
Room Françoise Barré-Sinoussi

Registration required for the 'Meet & Eat' - send us an email.

About the Lecture & Workshop series - Infection & Immunity

The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2018, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2018.

Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.

Where

32 rue Henri Koch
    Esch/Alzette 4354
    Luxembourg

When

From 01/02/2018 11:00
To 01/02/2018 14:00

Contact

Luxembourg Institute of Health
odoo@lih.lu