Lecture Series "Infection & Immunity" - Prof Max Löhning - "Quantitative control of T cell differentiation and memory in infections"
18/05/2017 11:45 to 18/05/2017 14:30 (Europe/Luxembourg)
CD4+ T helper (Th) cells secrete defined amounts of specific cytokines to determine not only the type of a particular immune response, but also its intensity. By single-cell analysis and mathematical modeling, we could show that during their initial activation, individual Th cells not only ‘learn’ which cytokines they should produce, but also in which quantity. This Quantitative Cytokine Memory is stably maintained in memory Th cells and recalled upon secondary antigen encounter (Helmstetter et al., Immunity 2015). While analyzing the signals inducing quantitative programming of T cells, we found that the alarmin interleukin (IL)-33 determines the intensity of activation of both CD8+ cytotoxic T cells (CTL) and Th type 1 (Th1) cells upon viral infection. IL-33 is required to enhance the clonal expansion of CTLs and Th1 cells and promote their differentiation to potent, polyfunctional effector cells (Bonilla et al., Science 2012; Baumann et al., PNAS 2015; Peine et al., Trends Immunol. 2016). Moreover, we demonstrated Th2 cell plasticity and a quantitative regulation of effector functions in individual Th cells via antagonizing key transcription factors (Hegazy et al., Immunity 2010). During parasite infections, hybrid Th1/Th2 cells are generated that stably co-express key Th1 and Th2 transcription factors. As these factors inhibit each other, a hybrid cell produces rather small amounts of Th1 and Th2 effector molecules. Yet, hybrid cells support both Th1 and Th2 immune responses while inducing less immunopathologic damage than classic Th1 or Th2 cells (Peine et al., PLoS Biol. 2013).
11:45 - 12:45 : LECTURE
Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle
13:00 - 14:30 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2017, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2017.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.