Lecture series Infection & Immunity: "MAPPING NUTRIENT UTILIZATION BY T CELLS IN VIVO: IMPLICATIONS FOR IMMUNITY" - Prof Russell Jones
16/01/2020 11:00 to 16/01/2020 14:00 (Europe/Luxembourg)
Metabolic reprogramming is an essential part of the T cell activation program. Upon activation, T cells undergo dramatic rewiring of their metabolic pathways to promote ATP production and biosynthesis sufficient to support the rapid exponential growth of antigen-specific T cells. The metabolic profile of T cells is shaped by both cell-intrinsic factors, such as genetics and receptor-mediated signaling, and environmental conditions, such as nutrient availability. We have combined classical immunological modeling of T cell responses with metabolic analysis (i.e., bioenergetic profiling, stable isotope tracing) to study the impact of metabolic reprogramming on T cell function. Our results indicate that CD8+ T cells display unique patterns of nutrient utilization in response to bacterial and viral pathogens in vivo, and that T cell metabolism changes over the course of infection. I will discuss how different carbon sources (e.g. glucose and glutamine) and amino acids (e.g. serine and methionine) are used to fuel T cell proliferation and effector function, and will discuss their impact on T cell function and adaptive immunity.
11:00 - 12:00 : LECTURE
Lycée Guillaume Kroll Salle de projection audiovisuelle
12:30 - 14:00 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Lectures will be organised, followed by workshops especially dedicated to early-stage researchers. Please find here the programme for 2020.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.