Lecture series Infection & Immunity: "DRIVING IMMUNITY: HOW CELLULAR METABOLISM INTEGRATES DIVERSE PROCESSES TO IMPACT IMMUNE FUNCTION" - Prof Erika Pearce
26/09/2019 11:00 to 26/09/2019 14:00 (Europe/Luxembourg)
Regulatory T cells (Tregs) subdue immune-mediated inflammation that is Associated with autoimmunity, but which can be beneficial for cancer rejection. Central to Treg activation are changes in lipid metabolism to support their survival and function. Fatty acid binding proteins (FABPs) are a family of lipid Chaperones required to facilitate the uptake and trafficking of intracellular lipids. One family member, FABP5, is expressed in certain T cell subsets, but its function Remains elusive. We show here that in Tregs, FABP5 inhibition causes mitochondrial defects, underscored by decreased OXPHOS, lipid elongation and desaturation, and loss of cristae structure, which augment their suppressive function. Mitochondrial dysfunction after FABP5 inhibi-tion results in mtDNA release and consequent cGAS/STING-dependent type I IFN signaling, which induces increased production of the regulatory cytokine IL-10, promoting Treg suppressive activity. Together these data reveal that FABP5 acts as a gatekeeper of mitochondrial health to control Treg function.
11:00 - 12:00 : LECTURE
Lycée Guillaume Kroll Salle de projection audiovisuelle
12:30 - 13:00 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2019, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2019.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.