Lecture Series Cancer Research - "TARGETING EPIGENETIC VULNERABILITIES IN GLIOMA, BIOMARKERS AND NEW OPPORTUNITIES" - Prof Monika Hegi

29/03/2018 11:00 to 29/03/2018 14:00 (Europe/Luxembourg)

Luxembourg, Luxembourg

 

Speaker

Prof Monika HEGI is Associate professor University of Lausanne and University Hospital Lausanne (CHUV), Director of the Laboratory of Brain Tumor Biology and Genetics, Deputy director of the Neuroscience Research Centre (CRN), Lausanne, Switzerland .

Abstract

Management of patients suffering from glioma remains a challenge. Over the last decade, the treatments have not changed, and consist of maximal save resection, followed by various schemes of chemo-radiotherapy. Therefore, new avenues have to be explored. The important role of epigenetic alterations in the development and treatment response of glioma has been recognized. Systematic analyses of the DNA methylome of gliomas has contributed to improved tumor classification, but has also identified vulnerabilities that can be exploited for therapy. Epigenetic silencing of the direct DNA repair gene MGMT predicts good response to alkylating agent therapy in glioblastoma, the most malignant form of glioma, and also in a subset of low-grade glioma. This can be used for stratified therapy and selection of patients into clinical trials. Additional, epigenetically altered pathways may be amenable to therapeutic targeting. In a second approach, the epigenetic landscape may be disturbed by interfering with the chromatin structure using epigenetic drugs, such as inhibitors of bromodomain and extra-terminal tail (BET) proteins. The BET proteins are chromatin readers that link the chromatin code to gene expression. Inhibition leads to changes in gene expression revealing potential pathway vulnerabilities that maybe actionable with a second drug.

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schedule

11.00 - 12.00: LECTURE

CHL, Amphitheatre

12.30 - 14.00: 'meet & eat'

LIH, BAM, Mc Clintock room

Registration required for the 'Meet & Eat' - send us an email

programme 2017-2018

About the Lecture & Workshop series - cancer research

The LIH lecture and workshops series in Cancer Research, supported by the FNR and jointly organized with the University of Luxembourg, are gathering internationally recognised speakers to address topics around Cancer Research.  Please find here he full programme for 2017-2018.

This lecture will be followed by a workshop especially dedicated to early-stage researchers.

Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.

Where

4, rue Barblé
    Luxembourg 1210
    Luxembourg

When

From 29/03/2018 11:00
To 29/03/2018 14:00

Contact

Luxembourg Institute of Health
odoo@lih.lu