Advancing personalised cancer treatment for patients with brain tumours. Help change the future of Brain Cancer treatment!
The high failure of therapeutic agents in clinical trials is often linked to inappropriate model systems used in the preclinical setting. Hence experimental models better reflecting human tumor biology are an unmet need. Over the years, our lab has set up a living biobank of brain tumor organoids from over 600 patients and has generated a large cohort (>40) of Patient-Derived Orthotopic Xenografts (PDOXs) for malignant gliomas (Glioblastoma and IDH-mutant high-grade gliomas). PDOX models enable long-term propagation of patient tumors and represent clinically relevant patient avatars. The NORLUX PDOX cohort contains tumors with different genetic, epigenetic and transcriptomic background recapitulating molecular subtypes of glioma tumors in patients.
Our cohort also comprises unique PDOXs derived from matched longitudinal samples of the same patient prior and after treatment. PDOXs allow to interrogate biological mechanisms of human tumor development in the brain microenvironment, functional validation studies and drug efficacy studies, including aspects of brain penetrance. Currently we are expanding our live biobank to obtain models representative of rarer glioma subtypes. We further plan to adapt the PDOX models to humanized immune-microenvironment, allowing for analysis and testing of novel immunotherapies.
NORLUX glioma models are described in Golebiewska et al, Acta Neuropathologica, 2020 and Oudin et al., STAR Protocols 2021.
NORLUX glioma PDOX models are available at the Patient-Derived Cancer Model (PDCM) Finder.
NORLUX is a member of the EurOPDX consortium.
🇬🇧 Immunological mechanisms of resistance to CDK4/6 inhibitors in HR+ breast cancer
Lecture Series Cancer Research
Speaker : Dr Lorenzo Galluzzi, PHD
04/04/2023 11:30
🇬🇧 Using Spatial Biology & Advanced Image Analysis Solutions to decipher tumour microenvironment and the drivers of cancer progression
Lecture Series Cancer Research
Speaker : Dr Gregory Hamm
06/04/2023 10:00
🇬🇧 COVIRNA Final Conference
19/04/2023 14:30
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