Rejko Krüger

Latest publications

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.

  • Transversal Translational Medicine
February 15, 2021
2021 Feb. Nat Genet. Online ahead of print.
By:
  • Chia R
  • Sabir MS
  • Bandres-Ciga S
  • Saez-Atienzar S
  • Reynolds RH
  • Gustavsson E
  • Walton RL
  • Ahmed S
  • Viollet C
  • Ding J
  • Makarious MB
  • Diez-Fairen M
  • Portley MK
  • Shah Z
  • Abramzon Y
  • Hernandez DG
  • Blauwendraat C
  • Stone DJ
  • Eicher J
  • Parkkinen L
  • Ansorge O
  • Clark L
  • Honig LS
  • Marder K
  • Lemstra A
  • St George-Hyslop P
  • Londos E
  • Morgan K
  • Lashley T
  • Warner TT
  • Jaunmuktane Z
  • Galasko D
  • Santana I
  • Tienari PJ
  • Myllykangas L
  • Oinas M
  • Cairns NJ
  • Morris JC
  • Halliday GM
  • Van Deerlin VM
  • Trojanowski JQ
  • Grassano M
  • Calvo A
  • Mora G
  • Canosa A
  • Floris G
  • Bohannan RC
  • Brett F
  • Gan-Or Z
  • Geiger JT
  • Moore A
  • May P
  • Kruger R
  • Goldstein DS
  • Lopez G
  • Tayebi N
  • Sidransky E
  • American Genome C
  • Norcliffe-Kaufmann L
  • Palma JA
  • Kaufmann H
  • Shakkottai VG
  • Perkins M
  • Newell KL
  • Gasser T
  • Schulte C
  • Landi F
  • Salvi E
  • Cusi D
  • Masliah E
  • Kim RC
  • Caraway CA
  • Monuki ES
  • Brunetti M
  • Dawson TM
  • Rosenthal LS
  • Albert MS
  • Pletnikova O
  • Troncoso JC
  • Flanagan ME
  • Mao Q
  • Bigio EH
  • Rodriguez-Rodriguez E
  • Infante J
  • Lage C
  • Gonzalez-Aramburu I
  • Sanchez-Juan P
  • Ghetti B
  • Keith J
  • Black SE
  • Masellis M
  • Rogaeva E
  • Duyckaerts C
  • Brice A
  • Lesage S
  • Xiromerisiou G
  • Barrett MJ
  • Tilley BS
  • Gentleman S
  • Logroscino G
  • Serrano GE
  • Beach TG
  • McKeith IG
  • Thomas AJ
  • Attems J
  • Morris CM
  • Palmer L
  • Love S
  • Troakes C
  • Al-Sarraj S
  • Hodges AK
  • Aarsland D
  • Klein G
  • Kaiser SM
  • Woltjer R
  • Pastor P
  • Bekris LM
  • Leverenz JB
  • Besser LM
  • Kuzma A
  • Renton AE
  • Goate A
  • Bennett DA
  • Scherzer CR
  • Morris HR
  • Ferrari R
  • Albani D
  • Pickering-Brown S
  • Faber K
  • Kukull WA
  • Morenas-Rodriguez E
  • Lleo A
  • Fortea J
  • Alcolea D
  • Clarimon J
  • Nalls MA
  • Ferrucci L
  • Resnick SM
  • Tanaka T
  • Foroud TM
  • Graff-Radford NR
  • Wszolek ZK
  • Ferman T
  • Boeve BF
  • Hardy JA
  • Topol EJ
  • Torkamani A
  • Singleton AB
  • Ryten M
  • Dickson DW
  • Chio A
  • Ross OA
  • Gibbs JR
  • Dalgard CL
  • Traynor BJ
  • Scholz SW.

The Role of DJ-1 in cellular metabolism and pathophysiological implications for Parkinson's disease.

  • Transversal Translational Medicine
  • Integrated BioBank of Luxembourg
February 07, 2021
2021 Feb. Cells.10(2).
By:
  • Mencke P
  • Boussaad I
  • Romano CD
  • Kitami T
  • Linster CL
  • Kruger R.

GP2: The Global Parkinson's Genetics Program.

  • Transversal Translational Medicine
January 29, 2021
2021 Jan. Mov Disord. Online ahead of print.
By:
  • Global Parkinson's Genetics Program
  • Kruger R (as member of the Global Parkinson’s Genetics Program).

Unmet needs of people with Parkinson's disease and their caregivers during COVID-19-related confinement: An explorative secondary data analysis.

  • Transversal Translational Medicine
January 18, 2021
2021 Jan. Front Neurol.11:615172.
By:
  • Hanff AM
  • Pauly C
  • Pauly L
  • Schroder VE
  • Hansen M
  • Meyers GR
  • Kaysen A
  • Hansen L
  • Wauters F
  • Kruger R.

Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening.

  • Transversal Translational Medicine
  • NORLUX Neuro-Oncology Laboratory
January 14, 2021
2021 Jan. Sci Rep.11(1):1439.
By:
  • Boussaad I
  • Cruciani G
  • Bolognin S
  • Antony P
  • Dording CM
  • Kwon YJ
  • Heutink P
  • Fava E
  • Schwamborn JC
  • Kruger R.

Human dopaminergic neurons lacking PINK1 exhibit disrupted dopamine metabolism related to vitamin B6 co-factors.

  • Transversal Translational Medicine
December 18, 2020
2020 Dec. iScience.23(12):101797. Epub 2019 Mar 1.
By:
  • Bus C
  • Zizmare L
  • Feldkaemper M
  • Geisler S
  • Zarani M
  • Schaedler A
  • Klose F
  • Admard J
  • Mageean CJ
  • Arena G
  • Fallier-Becker P
  • Ugun-Klusek A
  • Maruszczak KK
  • Kapolou K
  • Schmid B
  • Rapaport D
  • Ueffing M
  • Casadei N
  • Kruger R
  • Gasser T
  • Vogt Weisenhorn DM
  • Kahle PJ
  • Trautwein C
  • Gloeckner CJ
  • Fitzgerald JC.

Common diseases alter the physiological age-related blood microRNA profile.

  • Transversal Translational Medicine
November 24, 2020
2020 Nov. Nat Commun.11(1):5958.
By:
  • Fehlmann T
  • Lehallier B
  • Schaum N
  • Hahn O
  • Kahraman M
  • Li Y
  • Grammes N
  • Geffers L
  • Backes C
  • Balling R
  • Kern F
  • Kruger R
  • Lammert F
  • Ludwig N
  • Meder B
  • Fromm B
  • Maetzler W
  • Berg D
  • Brockmann K
  • Deuschle C
  • von Thaler AK
  • Eschweiler GW
  • Milman S
  • Barziliai N
  • Reichert M
  • Wyss-Coray T
  • Meese E
  • Keller A.

Contributing factors and evolution of impulse control disorder in the Luxembourg Parkinson cohort.

  • Competence Center for Methodology and Statistics
  • Clinical and Epidemiological Investigation Center
  • Transversal Translational Medicine
November 12, 2020
2020 Nov. Front Neurol.11:578924.
By:
  • Binck S
  • Pauly C
  • Vaillant M
  • Hipp G
  • Gantenbein M
  • Krueger R
  • Diederich NJ.

Mitochondria interaction networks show altered topological patterns in Parkinson's disease.

  • Immune Systems Biology
  • Allergy and Clinical Immunology
  • Transversal Translational Medicine
November 10, 2020
2020 Nov. NPJ Syst Biol Appl.6(1):38.
By:
  • Zanin M
  • Santos BFR
  • Antony PMA
  • Berenguer-Escuder C
  • Larsen SB
  • Hanss Z
  • Barbuti PA
  • Baumuratov AS
  • Grossmann D
  • Capelle CM
  • Weber J
  • Balling R
  • Ollert M
  • Kruger R
  • Diederich NJ
  • He FQ.

Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.

  • Transversal Translational Medicine
November 03, 2020
2020 Nov. Mov Disord. Online ahead of print.
By:
  • Hanss Z
  • Larsen SB
  • Antony P
  • Mencke P
  • Massart F
  • Jarazo J
  • Schwamborn JC
  • Barbuti PA
  • Mellick GD
  • Kruger R.

Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy.

  • Transversal Translational Medicine
October 07, 2020
2020 Oct. Sci Rep.10(1):16736.
By:
  • Neumann MA
  • Grossmann D
  • Schimpf-Linzenbold S
  • Dayan D
  • Stingl K
  • Ben-Menachem R
  • Pines O
  • Massart F
  • Delcambre S
  • Ghelfi J
  • Bohler J
  • Strom T
  • Kessel A
  • Azem A
  • Schols L
  • Grunewald A
  • Wissinger B
  • Kruger R.

[The history of Freezing-of-gait in Parkinson's disease - from phenomena to symptom].

  • Transversal Translational Medicine
September 22, 2020
2020 Sep. Fortschr Neurol Psychiatr.88(9):573-581. Epub 2020 Sep 21.
By:
  • Klucken J
  • Winkler J
  • Kruger R
  • Jost W.

The emerging role of RHOT1/Miro1 in the pathogenesis of Parkinson's disease.

  • Transversal Translational Medicine
September 15, 2020
2020 Sep. Front Neurol.11:587.
By:
  • Grossmann D
  • Berenguer-Escuder C
  • Chemla A
  • Arena G
  • Kruger R.

Using high-content screening to generate single-cell gene-corrected patient-derived iPS clones reveals excess alpha-synuclein with familial Parkinson’s disease point mutation A30P.

  • Transversal Translational Medicine
September 10, 2020
2020 Sep. Cells.9(9):pii: cells9092065.
By:
  • Barbuti P
  • Antony P
  • Santos B
  • Massart F
  • Cruciani G
  • Dording C
  • Arias J
  • Schwamborn J
  • Kruger R.

A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.

  • Transversal Translational Medicine
September 09, 2020
2020 Sep. Sci Transl Med.12(560).
By:
  • Boussaad I
  • Obermaier CD
  • Hanss Z
  • Bobbili DR
  • Bolognin S
  • Glaab E
  • Wołyńska K
  • Weisschuh N
  • De Conti L
  • May C
  • Giesert F
  • Grossmann D
  • Lambert A
  • Kirchen S
  • Biryukov M
  • Burbulla LF
  • Massart F
  • Bohler J
  • Cruciani G
  • Schmid B
  • Kurz-Drexler A
  • May P
  • Duga S
  • Klein C
  • Schwamborn JC
  • Marcus K
  • Woitalla D
  • Vogt Weisenhorn DM
  • Wurst W
  • Baralle M
  • Krainc D
  • Gasser T
  • Wissinger B
  • Krüger R.

Excess of singleton loss-of-function variants in Parkinson's disease contributes to genetic risk.

  • Transversal Translational Medicine
September 01, 2020
2020 Sep. J Med Genet.57(9):617-623. Epub 2020 Feb 13.
By:
  • Bobbili DR
  • Banda P
  • Kruger R
  • May P.

[Emerging concepts for precision medicine in Parkinson's disease with focus on genetics].

  • Transversal Translational Medicine
September 01, 2020
2020 Sep. Fortschr Neurol Psychiatr.88(9):558-566. Epub 2020 Jun 2.
By:
  • Stute L
  • Kruger R.

[The role of inhibitors of COMT and MAO-B in the therapy of Parkinson's disease].

  • Transversal Translational Medicine
September 01, 2020
2020 Sep. Fortschr Neurol Psychiatr.88(9):620-633. Epub 2020 Jun 25.
By:
  • Woitalla D
  • Kruger R
  • Lorenzl S
  • Muller T
  • Oelwein G
  • Storch A
  • Wolz M
  • Wullner U.

Bidirectional relation between Parkinson's Disease and glioblastoma multiforme.

  • Transversal Translational Medicine
August 20, 2020
2020 Aug. Front Neurol.11:898.
By:
  • Mencke P
  • Hanss Z
  • Boussaad I
  • Sugier PE
  • Elbaz A
  • Kruger R.

Generation of two iPS cell lines (HIHDNDi001-A and HIHDNDi001-B) from a Parkinson's disease patient carrying the heterozygous p.A30P mutation in SNCA.

  • Transversal Translational Medicine
August 08, 2020
2020 Aug. Stem Cell Res.48:101951. Epub 2020 Aug 8.
By:
  • Barbuti PA
  • Santos BFR
  • Dording CM
  • Cruciani G
  • Massart F
  • Hummel A
  • Kruger R.