Latest publications

Epigenetic activity of peroxisome proliferator-activated receptor gamma agonists increases the anticancer effect of histone deacetylase inhibitors on multiple myeloma cells.

  • Tumor Immunotherapy and Microenvironment
  • Translational Radiomics
  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
June 19, 2015
2015 Jun. PLoS One.10(6):e0130339.
By:
  • Aouali N
  • Broukou A
  • Bosseler M
  • Keunen O
  • Schlesser V
  • Janji B
  • Palissot V
  • Stordeur P
  • Berchem G.
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Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450.

  • Tumor Immunotherapy and Microenvironment
June 11, 2015
2015 Jun. Cell Death Dis.6:e1782.
By:
  • Cerella C
  • Muller F
  • Gaigneaux A
  • Radogna F
  • Viry E
  • Chateauvieux S
  • Dicato M
  • Diederich M.
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Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression.

  • Tumor Immunotherapy and Microenvironment
April 23, 2015
2015 Apr. Oncogene.34(17):2261-71. Epub 2014 Jun 16.
By:
  • Akalay I
  • Tan TZ
  • Kumar P
  • Janji B
  • Mami-Chouaib F
  • Charpy C
  • Vielh P
  • Larsen AK
  • Thiery JP
  • Sabbah M
  • Chouaib S.
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The autophagy sensor ITPR1 protects renal carcinoma cells from NK-mediated killing.

  • Tumor Immunotherapy and Microenvironment
February 25, 2015
2015 Feb. Autophagy. [Epub ahead of print].
By:
  • Messai Y
  • Noman MZ
  • Janji B
  • Hasmim M
  • Escudier B
  • Chouaib S.
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First-line crizotinib versus chemotherapy in ALK-positive lung cancer.

  • Tumor Immunotherapy and Microenvironment
December 04, 2014
2014 Dec. N Engl J Med.371(23):2167-77.
By:
  • Solomon BJ
  • Mok T
  • Kim DW
  • Wu YL
  • Nakagawa K
  • Mekhail T
  • Felip E
  • Cappuzzo F
  • Paolini J
  • Usari T
  • Iyer S
  • Reisman A
  • Wilner KD
  • Tursi J
  • Blackhall F
  • PROFILE 1014 Investigators (Berchem G as collaborator for this project).
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ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy.

  • Tumor Immunotherapy and Microenvironment
December 01, 2014
2014 Dec. Cancer Res.74(23):6820-32. Epub 2014 Oct 8.
By:
  • Messai Y
  • Noman MZ
  • Hasmim M
  • Janji B
  • Tittarelli A
  • Boutet M
  • Baud V
  • Viry E
  • Billot K
  • Nanbakhsh A
  • Ben Safta T
  • Richon C
  • Ferlicot S
  • Donnadieu E
  • Couve S
  • Gardie B
  • Orlanducci F
  • Albiges L
  • Thiery J
  • Olive D
  • Escudier B
  • Chouaib S.
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Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
  • Cytoskeleton and Cancer Progression
November 20, 2014
2014 Nov. J Imm Res.1(2):7.
By:
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Viry E
  • Al-Absi A
  • Medves S
  • Moussay E
  • Berchem G
  • Thomas C
  • Janji B.
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Two biomarker-directed randomized trials in European and Chinese patients with nonsmall-cell lung cancer: the BRCA1-RAP80 Expression Customization (BREC) studies.

  • Tumor Immunotherapy and Microenvironment
November 01, 2014
2014 Nov. Ann Oncol.25(11):2147-55. Epub 2014 Aug 27.
By:
  • Moran T
  • Wei J
  • Cobo M
  • Qian X
  • Domine M
  • Zou Z
  • Bover I
  • Wang L
  • Provencio M
  • Yu L
  • Chaib I
  • You C
  • Massuti B
  • Song Y
  • Vergnenegre A
  • Lu H
  • Lopez-Vivanco G
  • Hu W
  • Robinet G
  • Yan J
  • Insa A
  • Xu X
  • Majem M
  • Chen X
  • de Las Penas R
  • Karachaliou N
  • Sala MA
  • Wu Q
  • Isla D
  • Zhou Y
  • Baize N
  • Zhang F
  • Garde J
  • Germonpre P
  • Rauh S
  • H AL
  • Sanchez-Ronco M
  • Drozdowskyj A
  • Sanchez JJ
  • Camps C
  • Liu B
  • Rosell R
  • Spanish Lung Cancer Group
  • French Lung Cancer Group
  • Comprehensive Cancer Centre of Drum Tower Hospital in Nanjing
  • Berchem G (as collaborator for investigators participating in the BREC trials).
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Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
November 01, 2014
2014 Nov. Biochem Pharmacol.92(1):31-42. Epub 2014 Jul 17.
By:
  • Viry E
  • Paggetti J
  • Baginska J
  • Mgrditchian T
  • Berchem G
  • Moussay E
  • Janji B.
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Hypoxia-induced autophagy in tumor cells: a key target for improving cancer immunotherapy.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
September 14, 2014
2014 Sep. Cancer Cell Microenviron.1(4):e213.
By:
  • Paggetti J
  • Viry E
  • Berchem G
  • Moussay E
  • Janji B.
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[Editorial].

  • Tumor Immunotherapy and Microenvironment
August 01, 2014
2014 Aug. Bull Soc Sci Med Grand Duche Luxemb.(2):7-8.
By:
  • Berchem G.
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BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization.

  • Tumor Immunotherapy and Microenvironment
July 01, 2014
2014 Jul. Autophagy.10(7):1341-1342. Epub 2014 May 15.
By:
  • Sebti S
  • Prebois C
  • Perez-Gracia E
  • Bauvy C
  • Desmots F
  • Pirot N
  • Gongora C
  • Bach AS
  • Hubberstey AV
  • Palissot V
  • Berchem G
  • Codogno P
  • Linares LK
  • Liaudet-Coopman E
  • Pattingre S.
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Tumor plasticity interferes with anti-tumor immunity.

  • Tumor Immunotherapy and Microenvironment
June 19, 2014
2014 Jun. Crit Rev Immunol.34(2):91-102.
By:
  • Chouaib S
  • Janji B
  • Tittarelli A
  • Eggermont A
  • Thiery JP.
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PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation.

  • Tumor Immunotherapy and Microenvironment
May 05, 2014
2014 May. J Exp Med.211(5):781-90. Epub 2014 Apr 28.
By:
  • Noman MZ
  • Desantis G
  • Janji B
  • Hasmim M
  • Karray S
  • Dessen P
  • Bronte V
  • Chouaib S.
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Bronchial airway gene expression in smokers with lung or head and neck cancer.

  • NORLUX Neuro-Oncology Laboratory
  • Platform LUXGEN - Micro-Array
  • Tumor Immunotherapy and Microenvironment
April 01, 2014
2014 Apr. Cancer Med.3(2):322-36. Epub 2014 Feb 4.
By:
  • Van Dyck E
  • Nazarov PV
  • Muller A
  • Nicot N
  • Bosseler M
  • Pierson S
  • Van Moer K
  • Palissot V
  • Mascaux C
  • Knolle U
  • Ninane V
  • Nati R
  • Bremnes RM
  • Vallar L
  • Berchem G
  • Schlesser M.
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BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.

  • Tumor Immunotherapy and Microenvironment
March 18, 2014
2014 Mar. Proc Natl Acad Sci U S A.111(11):4115-20. Epub 2014 Mar 3.
By:
  • Sebti S
  • Prebois C
  • Perez-Gracia E
  • Bauvy C
  • Desmots F
  • Pirot N
  • Gongora C
  • Bach AS
  • Hubberstey AV
  • Palissot V
  • Berchem G
  • Codogno P
  • Linares LK
  • Liaudet-Coopman E
  • Pattingre S.
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Autophagic degradation of GZMB/granzyme B: a new mechanism of hypoxic tumor cell escape from natural killer cell-mediated lysis.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
January 01, 2014
2014 Jan. Autophagy.10(1):173-5. Epub 2013 Nov 15.
By:
  • Viry E
  • Baginska J
  • Berchem G
  • Noman MZ
  • Medves S
  • Chouaib S
  • Janji B.
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The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
December 01, 2013
2013 Dec. Front Immunol.4:490.
By:
  • Baginska J
  • Viry E
  • Paggetti J
  • Medves S
  • Berchem G
  • Moussay E
  • Janji B.
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Study of the involvement of autophagy in the acquisition of tumor resistance to Natural Killer-mediated lysis. (Doctoral thesis)

  • Tumor Immunotherapy and Microenvironment
November 28, 2013
2013 Nov. Paris: Université Paris-Sud, 2013. 132 p.
By:
  • Baginska J.
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Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia.

  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
October 22, 2013
2013 Oct. Proc Natl Acad Sci U S A.110(43):17450-5. Epub 2013 Oct 7.
By:
  • Baginska J
  • Viry E
  • Berchem G
  • Poli A
  • Noman MZ
  • van Moer K
  • Medves S
  • Zimmer J
  • Oudin A
  • Niclou SP
  • Bleackley RC
  • Goping IS
  • Chouaib S
  • Janji B.
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