Latest publications

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity.

  • Tumor Immunotherapy and Microenvironment
January 17, 2017
2017 Jan. OncoImmunology.6(2):e1271858.
By:
  • Terry S
  • Buart S
  • Tan TZ
  • Gros G
  • Noman MZ
  • Lorens JB
  • Mami-Chouaib F
  • Thiery JP
  • Chouaib S.

Randomized phase II study of cabazitaxel versus methotrexate in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck previously treated with platinum-based therapy.

  • Tumor Immunotherapy and Microenvironment
December 01, 2016
2016 Dec. Oncologist.21(12):1416-e17. Epub 2016 Nov 30.
By:
  • Machiels JP
  • Van Maanen A
  • Vandenbulcke JM
  • Filleul B
  • Seront E
  • Henry S
  • D'Hondt L
  • Lonchay C
  • Holbrechts S
  • Boegner P
  • Brohee D
  • Dequanter D
  • Louviaux I
  • Sautois B
  • Whenham N
  • Berchem G
  • Vanderschueren B
  • Fontaine C
  • Schmitz S
  • Gillain A
  • Schoonjans J
  • Rottey S.

Hijacker of the antitumor immune response: autophagy is showing its worst facet.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
November 18, 2016
2016 Nov. Front Oncol.6(246):246.
By:
  • Viry E
  • Noman MZ
  • Arakelian T
  • Lequeux A
  • Chouaib S
  • Berchem G
  • Moussay E
  • Paggetti J
  • Janji B.

Mesenchymal stromal cells can regulate the immune response in the tumor microenvironment.

  • Tumor Immunotherapy and Microenvironment
November 08, 2016
2016 Nov. Vaccines.4(4).
By:
  • Poggi A
  • Giuliani M.

Renal cell carcinoma programmed death-ligand 1, a new direct target of hypoxia-inducible factor-2 alpha, is regulated by von Hippel-Lindau gene mutation status.

  • Tumor Immunotherapy and Microenvironment
October 01, 2016
2016 Oct. Eur Urol.70(4):623-632. Epub 2015 Dec 23.
By:
  • Messai Y
  • Gad S
  • Noman MZ
  • Le Teuff G
  • Couve S
  • Janji B
  • Kammerer SF
  • Rioux-Leclerc N
  • Hasmim M
  • Ferlicot S
  • Baud V
  • Mejean A
  • Mole DR
  • Richard S
  • Eggermont AM
  • Albiges L
  • Mami-Chouaib F
  • Escudier B
  • Chouaib S.

miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function.

  • Tumor Immunotherapy and Microenvironment
September 28, 2016
2016 Sep. Cancer Lett.380(1):257-62. Epub 2015 Oct 30.
By:
  • Noman MZ
  • Janji B
  • Berchem G
  • Chouaib S.

Role of autophagy in tumor progression and regression. In Targeting autophagy in cancer therapy. (Book Chapter)

  • Tumor Immunotherapy and Microenvironment
September 03, 2016
2016 Sep. Yang J-M, ed. Springer International Publishing, 2016. p.117-131. (Current Cancer Research). ISBN 978-3-319-42740-9.
By:
  • Janji B
  • Chouaib S.

The multifaceted role of autophagy in tumor evasion from immune surveillance.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 05, 2016
2016 Apr. Oncotarget.7(14):17591-607.
By:
  • Janji B
  • Viry E
  • Moussay E
  • Paggetti J
  • Arakelian T
  • Mgrditchian T
  • Messai Y
  • Noman MZ
  • Van Moer K
  • Hasmim M
  • Mami-Chouaib F
  • Berchem G
  • Chouaib S.

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-beta and miR23a transfer.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 01, 2016
2016 Apr. OncoImmunology.5(4):e1062968. Epub 2015 Jun 24.
By:
  • Berchem G
  • Noman MZ
  • Bosseler M
  • Paggetti J
  • Baconnais S
  • Le Cam E
  • Nanbakhsh A
  • Moussay E
  • Mami-Chouaib F
  • Janji B
  • Chouaib S.

Prospective evaluation of first-Line erlotinib in advanced Non-Small Cell Lung Cancer (NSCLC) carrying an activating EGFR mutation: A multicenter academic phase II study in Caucasian patients (FIELT).

  • Tumor Immunotherapy and Microenvironment
March 31, 2016
2016 Mar. PLoS One.11(3):e0147599.
By:
  • De Greve J
  • Van Meerbeeck J
  • Vansteenkiste JF
  • Decoster L
  • Meert AP
  • Vuylsteke P
  • Focan C
  • Canon JL
  • Humblet Y
  • Berchem G
  • Colinet B
  • Galdermans D
  • Bosquee L
  • Vermeij J
  • Dewaele A
  • Geers C
  • Schallier D
  • Teugels E.

Autophagy Activation in the Tumor Microenvironment: A Major Process in Shaping the Antitumor Immune Response. In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 1st ed. (Book Chapter)

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
February 25, 2016
2016 Feb. San Diego: Academic Press, 2016. p.267-290. (Vol. 8). ISBN 978-0-12-802937-4.
By:
  • Janji B
  • Viry E
  • Mgrditchian T
  • Arakelian T
  • Medves S
  • Berchem G.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

  • Proteomics of Cellular Signaling
  • Tumor Immunotherapy and Microenvironment
January 02, 2016
2016 Jan. Autophagy.12(1):1-222.
By:
  • Klionsky D
  • Abdelmohsenn K
  • Abe A
  • Abedin M
  • et al (incl. El-Khoury V Janji B and Berchem G).

Autophagy regulation of the tumor immunity: An old housekeeper for a new function. In Cell Death - Autophagy, Necrosis and Apoptosis. (Book Chapter)

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
December 16, 2015
2015 Dec. Ntuli DT, ed. Rijeka: InTech, 2015. p.37-61. ISBN 978-953-51-2236-4.
By:
  • Arakelian T
  • Mgrditchian T
  • Viry E
  • Van Moer K
  • Berchem G
  • Chouaib S
  • Janji B.

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia.

  • Tumor Immunotherapy and Microenvironment
November 01, 2015
2015 Nov. Am J Physiol Cell Physiol.309(9):C569-79. Epub 2015 Aug 26.
By:
  • Noman MZ
  • Hasmim M
  • Messai Y
  • Terry S
  • Kieda C
  • Janji B
  • Chouaib S.

miR-181a modulates acute myeloid leukemia susceptibility to natural killer cells.

  • Tumor Immunotherapy and Microenvironment
October 16, 2015
2015 Oct. OncoImmunology.4(12):e996475.
By:
  • Nanbakhsh A
  • Visentin G
  • Olive D
  • Janji B
  • Mussard E
  • Dessen P
  • Meurice G
  • Zhang Y
  • Louache F
  • Bourhis JH
  • Chouaib S.

The selective degradation of synaptic connexin 43 protein by hypoxia-induced autophagy impairs natural killer cell-mediated tumor cell killing.

  • Tumor Immunotherapy and Microenvironment
September 25, 2015
2015 Sep. J Biol Chem.290(39):23670-9. Epub 2015 Jul 28.
By:
  • Tittarelli A
  • Janji B
  • Van Moer K
  • Noman MZ
  • Chouaib S.

Tumor-promoting effects of myeloid derived suppressor cells are potentiated by hypoxia-induced expression of miR-210.

  • Tumor Immunotherapy and Microenvironment
September 15, 2015
2015 Sep. Cancer Res.75(18):3771-87. Epub 2015 Jul 23.
By:
  • Noman MZ
  • Janji B
  • Hu S
  • Wu JC
  • Martelli F
  • Bronte V
  • Chouaib S.

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
  • Integrated BioBank of Luxembourg
  • Proteomics of Cellular Signaling
August 27, 2015
2015 Aug. Blood.126(9):1106-17. Epub 2015 Jun 22.
By:
  • Paggetti J
  • Haderk F
  • Seiffert M
  • Janji B
  • Distler U
  • Ammerlaan W
  • Kim YJ
  • Adam J
  • Lichter P
  • Solary E
  • Berchem G
  • Moussay E.

Screening protein isoforms predictive for cancer using immunoaffinity capture and fast LC-MS in PRM mode.

  • Proteomics of Cellular Signaling
  • Tumor Immunotherapy and Microenvironment
August 01, 2015
2015 Aug. Proteomics Clin Appl.9(7-8):695-705. Epub 2015 Mar 30.
By:
  • Lesur A
  • Ancheva L
  • Kim YJ
  • Berchem G
  • van Oostrum J
  • Domon B.

Hypoxia: A Formidable Saboteur of the Anti-tumor Response. In Resistance of Cancer Cells to CTL-Mediated Immunotherapy. (Book Chapter)

  • Tumor Immunotherapy and Microenvironment
June 20, 2015
2015 Jun. Bonavida B and Chouaib S, eds. Springer, 2015. p.115-142. (Series Resistance to Targeted Anti-Cancer Therapeutics, Vol. 7). ISBN 978-3-319-17806-6.
By:
  • Hasmim M
  • Messai Y
  • Terry S
  • Janji B
  • Noman M
  • Chouaib S.