Latest publications

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • Tumor Immunotherapy and Microenvironment
September 05, 2017
2017 Sep. Br J Cancer.117(6):813-825. Epub 2017 Aug 10.
By:
  • Abdul Rahim SA
  • Dirkse A
  • Oudin A
  • Schuster A
  • Bohler J
  • Barthelemy V
  • Muller A
  • Vallar L
  • Janji B
  • Golebiewska A
  • Niclou SP.
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Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination.

  • NORLUX Neuro-Oncology Laboratory
September 05, 2017
2017 Sep. J Exp Clin Cancer Res.36(1):118.
By:
  • Zhang X
  • Xu R
  • Zhang C
  • Xu Y
  • Han M
  • Huang B
  • Chen A
  • Qiu C
  • Thorsen F
  • Prestegarden L
  • Bjerkvig R
  • Wang J
  • Li X.
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MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1.

  • NORLUX Neuro-Oncology Laboratory
September 04, 2017
2017 Sep. J Cell Biol.216(9):2715-2729. Epub 2017 Jul 24.
By:
  • Hau AC
  • Grebbin BM
  • Agoston Z
  • Anders-Maurer M
  • Muller T
  • Gross A
  • Kolb J
  • Langer JD
  • Doring C
  • Schulte D.
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The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells.

  • NORLUX Neuro-Oncology Laboratory
August 10, 2017
2017 Aug. J Exp Clin Cancer Res.36(1):106.
By:
  • Atzori MG
  • Tentori L
  • Ruffini F
  • Ceci C
  • Lisi L
  • Bonanno E
  • Scimeca M
  • Eskilsson E
  • Daubon T
  • Miletic H
  • Ricci Vitiani L
  • Pallini R
  • Navarra P
  • Bjerkvig R
  • D'Atri S
  • Lacal PM
  • Graziani G.
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Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

  • Luxembourg Center of Neuropathology
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • NORLUX Neuro-Oncology Laboratory
August 01, 2017
2017 Aug. Int J Oncol.51(2):702-714. Epub 2017 Jun 21.
By:
  • Armento A
  • Ilina EI
  • Kaoma T
  • Muller A
  • Vallar L
  • Niclou SP
  • Kruger MA
  • Mittelbronn M
  • Naumann U.
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Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy.

  • NORLUX Neuro-Oncology Laboratory
August 01, 2017
2017 Aug. Biochim Biophys Acta-Rev Cancer.1868(1):109-116. Epub 2017 Mar 1.
By:
  • Neirinckx V
  • Hedman H
  • Niclou SP.
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Cathepsin L silencing increases As2O3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7.

  • NORLUX Neuro-Oncology Laboratory
July 01, 2017
2017 Jul. Exp Cell Res.356(1):64-73. Epub 2017 Apr 12.
By:
  • Primon M
  • Huszthy PC
  • Motaln H
  • Talasila KM
  • Miletic H
  • Atai NA
  • Bjerkvig R
  • Lah Turnsek T.
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Aptamer functionalization of nanosystems for glioblastoma targeting through the blood-brain barrier.

  • NORLUX Neuro-Oncology Laboratory
May 25, 2017
2017 May. J Med Chem.60(10):4510-4516. Epub 2017 May 10.
By:
  • Monaco I
  • Camorani S
  • Colecchia D
  • Locatelli E
  • Calandro P
  • Oudin A
  • Niclou S
  • Arra C
  • Chiariello M
  • Cerchia L
  • Comes Franchini M.
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Large-Scale SRM Screen of Urothelial Bladder Cancer Candidate Biomarkers in Urine.

  • Proteomics of Cellular Signaling
  • NORLUX Neuro-Oncology Laboratory
April 07, 2017
2017 Apr. J Proteome Res.16(4):1617-1631. Epub 2017 Mar 23.
By:
  • Duriez E
  • Masselon CD
  • Mesmin C
  • Court M
  • Demeure K
  • Allory Y
  • Malats N
  • Matondo M
  • Radvanyi F
  • Garin J
  • Domon B.
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Cellular and molecular characterization of microglia: A unique immune cell population.

  • NORLUX Neuro-Oncology Laboratory
March 02, 2017
2017 Mar. Front Immunol.8:198.
By:
  • Sousa C
  • Biber K
  • Michelucci A.
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The angiogenic switch leads to a metabolic shift in human glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
March 01, 2017
2017 Mar. Neuro Oncol.19(3):383-393.
By:
  • Talasila KM
  • Rosland GV
  • Hagland HR
  • Eskilsson E
  • Flones IH
  • Fritah S
  • Azuaje F
  • Atai N
  • Harter PN
  • Mittelbronn M
  • Andersen M
  • Joseph JV
  • Hossain JA
  • Vallar L
  • Noorden CJ
  • Niclou SP
  • Thorsen F
  • Tronstad KJ
  • Tzoulis C
  • Bjerkvig R
  • Miletic H.
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EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
December 01, 2016
2016 Dec. Neuro Oncol.18(12):1644-1655. Epub 2016 Jun 10.
By:
  • Eskilsson E
  • Rosland GV
  • Talasila KM
  • Knappskog S
  • Keunen O
  • Sottoriva A
  • Foerster S
  • Solecki G
  • Taxt T
  • Jirik R
  • Fritah S
  • Harter PN
  • Valk K
  • Al Hossain J
  • Joseph JV
  • Jahedi R
  • Saed HS
  • Piccirillo SG
  • Spiteri I
  • Leiss L
  • Euskirchen P
  • Graziani G
  • Daubon T
  • Lund-Johansen M
  • Enger PO
  • Winkler F
  • Ritter CA
  • Niclou SP
  • Watts C
  • Bjerkvig R
  • Miletic H.
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Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs.

  • NORLUX Neuro-Oncology Laboratory
November 01, 2016
2016 Nov. Am J Cancer Res.6(11):2514-2531.
By:
  • Du Four S
  • Maenhout SK
  • Niclou SP
  • Thielemans K
  • Neyns B
  • Aerts JL.
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Inflammation promotes a conversion of astrocytes into neural progenitor cells via NF-kappaB activation.

  • NORLUX Neuro-Oncology Laboratory
October 01, 2016
2016 Oct. Mol Neurobiol.53(8):5041-55. Epub 2015 Sep 17.
By:
  • Gabel S
  • Koncina E
  • Dorban G
  • Heurtaux T
  • Birck C
  • Glaab E
  • Michelucci A
  • Heuschling P
  • Grandbarbe L.
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Rapid conversion of mutant IDH1 from driver to passenger in a model of human gliomagenesis.

  • NORLUX Neuro-Oncology Laboratory
October 01, 2016
2016 Oct. Mol Cancer Res.14(10):976-983. Epub 2016 Jul 18.
By:
  • Johannessen TA
  • Mukherjee J
  • Viswanath P
  • Ohba S
  • Ronen SM
  • Bjerkvig R
  • Pieper RO.
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Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells.

  • NORLUX Neuro-Oncology Laboratory
September 01, 2016
2016 Sep. J Gene Med.18(9):234-43.
By:
  • Hossain JA
  • Ystaas LR
  • Mrdalj J
  • Valk K
  • Riecken K
  • Fehse B
  • Bjerkvig R
  • Gronli J
  • Miletic H.
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The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.

  • NORLUX Neuro-Oncology Laboratory
August 01, 2016
2016 Aug. Mol Neurobiol.53(6):3724-3739. Epub 2015 Jul 4.
By:
  • Michelucci A
  • Bithell A
  • Burney MJ
  • Johnston CE
  • Wong KY
  • Teng SW
  • Desai J
  • Gumbleton N
  • Anderson G
  • Stanton LW
  • Williams BP
  • Buckley NJ.
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Pbx1 is required for adult subventricular zone neurogenesis.

  • NORLUX Neuro-Oncology Laboratory
July 01, 2016
2016 Jul. Development.143(13):2281-91. Epub 2016 May 25.
By:
  • Grebbin BM
  • Hau AC
  • Gross A
  • Anders-Maurer M
  • Schramm J
  • Koss M
  • Wille C
  • Mittelbronn M
  • Selleri L
  • Schulte D.
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Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels.

  • NORLUX Neuro-Oncology Laboratory
July 01, 2016
2016 Jul. J Biol Chem.291(27):14274-84. Epub 2016 May 9.
By:
  • Cordes T
  • Wallace M
  • Michelucci A
  • Divakaruni AS
  • Sapcariu SC
  • Sousa C
  • Koseki H
  • Cabrales P
  • Murphy AN
  • Hiller K
  • Metallo CM.
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DNA repair mechanisms and their clinical impact in glioblastoma.

  • DNA Repair and Chemoresistance
  • NORLUX Neuro-Oncology Laboratory
July 01, 2016
2016 Jul. Mutat Res Rev Mutat Res.769:19-35. Epub 2016 Jun 21.
By:
  • Erasimus H
  • Gobin M
  • Niclou S
  • Van Dyck E.
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