Latest publications

EGFL7 enhances surface expression of integrin alpha5beta1 to promote angiogenesis in malignant brain tumors.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. EMBO Mol Med.10(9).
By:
  • Dudvarski Stankovic N
  • Bicker F
  • Keller S
  • Jones DT
  • Harter PN
  • Kienzle A
  • Gillmann C
  • Arnold P
  • Golebiewska A
  • Keunen O
  • Giese A
  • von Deimling A
  • Bauerle T
  • Niclou SP
  • Mittelbronn M
  • Ye W
  • Pfister SM
  • Schmidt MHH.

Microglia in health and disease: a unique immune cell population.

  • NORLUX Neuro-Oncology Laboratory
  • Luxembourg Center of Neuropathology
August 15, 2018
2018 Aug. Front Immunol.9:1779.
By:
  • Michelucci A
  • Mittelbronn M
  • Gomez-Nicola D.

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy.

  • NORLUX Neuro-Oncology Laboratory
July 19, 2018
2018 Jul. Autophagy.14(11):2007-2022. Epub 2018 Aug 17.
By:
  • Wang J
  • Qi Q
  • Zhou W
  • Feng Z
  • Huang B
  • Chen A
  • Zhang D
  • Li W
  • Zhang Q
  • Jiang Z
  • Bjerkvig R
  • Prestegarden L
  • Thorsen F
  • Wang X
  • Li X
  • Wang J.

Investigation of IDH-mutant Gliomas Metabolism by Mass Spectrometry Imaging (Application Note #MSI-16)

  • NORLUX Neuro-Oncology Laboratory
June 25, 2018
2018 Jun. Imabiotech, 2018. 4 p.
By:
  • Hochart G
  • Fack F
  • Tardito S
  • Stauber J
  • Fontaine E
  • Niclou S
  • Stauber J.

Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal AnalySiS Consortium.

  • NORLUX Neuro-Oncology Laboratory
June 18, 2018
2018 Jun. Neuro Oncol.20(7):873-884.
By:
  • Aldape K
  • Amin SB
  • Ashley DM
  • Barnholtz-Sloan JS
  • Bates AJ
  • Beroukhim R
  • Bock C
  • Brat DJ
  • Claus EB
  • Costello JF
  • de Groot JF
  • Finocchiaro G
  • French PJ
  • Gan HK
  • Griffith B
  • Herold-Mende CC
  • Horbinski C
  • Iavarone A
  • Kalkanis SN
  • Karabatsou K
  • Kim H
  • Kouwenhoven MCM
  • McDonald KL
  • Miletic H
  • Nam DH
  • Ng HK
  • Niclou SP
  • Noushmehr H
  • Ormond R
  • Poisson LM
  • Reifenberger G
  • Roncaroli F
  • Sa JK
  • Sillevis Smitt PAE
  • Smits M
  • Souza CF
  • Tabatabai G
  • Van Meir EG
  • Verhaak RGW
  • Watts C
  • Wesseling P
  • Woehrer A
  • Yung WKA
  • Jungk C
  • Hau AC
  • van Dyck E
  • Westerman BA
  • Yin J
  • Abiola O
  • Zeps N
  • Grimmond S
  • Buckland M
  • Khasraw M
  • Sulman EP
  • Muscat AM
  • Stead L
  • Glass Consortium.

EGFR heterogeneity and implications for therapeutic intervention in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
May 18, 2018
2018 May. Neuro Oncol.20(6):743-752.
By:
  • Eskilsson E
  • Rosland GV
  • Solecki G
  • Wang Q
  • Harter PN
  • Graziani G
  • Verhaak RGW
  • Winkler F
  • Bjerkvig R
  • Miletic H.

Pericytes/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma.

  • Luxembourg Center of Neuropathology
  • NORLUX Neuro-Oncology Laboratory
May 08, 2018
2018 May. Oncotarget.9(35):24041-24053.
By:
  • Mader L
  • Blank AE
  • Capper D
  • Jansong J
  • Baumgarten P
  • Wirsik NM
  • Zachskorn C
  • Ehlers J
  • Seifert M
  • Klink B
  • Liebner S
  • Niclou S
  • Naumann U
  • Harter PN
  • Mittelbronn M.

Increased formate overflow is a hallmark of oxidative cancer.

  • NORLUX Neuro-Oncology Laboratory
April 10, 2018
2018 Apr. Nat Commun.9(1):1368.
By:
  • Meiser J
  • Schuster A
  • Pietzke M
  • Vande Voorde J
  • Athineos D
  • Oizel K
  • Burgos-Barragan G
  • Wit N
  • Dhayade S
  • Morton JP
  • Dornier E
  • Sumpton D
  • Mackay GM
  • Blyth K
  • Patel KJ
  • Niclou SP
  • Vazquez A.

Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors.

  • NORLUX Neuro-Oncology Laboratory
April 10, 2018
2018 Apr. Stem Cell Reports.10(4):1184-1192.
By:
  • Kolb J
  • Anders-Maurer M
  • Muller T
  • Hau AC
  • Grebbin BM
  • Kallenborn-Gerhardt W
  • Behrends C
  • Schulte D.

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Platform National Cytometry
  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
  • Allergy and Clinical Immunology
April 05, 2018
2018 Apr. Blood.131(14):1617-1621. Epub 2018 Feb 13.
By:
  • Wierz M
  • Pierson S
  • Guyonnet L
  • Viry E
  • Lequeux A
  • Oudin A
  • Niclou SP
  • Ollert M
  • Berchem G
  • Janji B
  • Guerin C
  • Paggetti J
  • Moussay E.

DNA methylation-based classification of central nervous system tumours.

  • NORLUX Neuro-Oncology Laboratory
  • Luxembourg Center of Neuropathology
March 22, 2018
2018 Mar. Nature.555(7697):469-474. Epub 2018 Mar 14.
By:
  • Capper D
  • Jones DTW
  • Sill M
  • Hovestadt V
  • Schrimpf D
  • Sturm D
  • Koelsche C
  • Sahm F
  • Chavez L
  • Reuss DE
  • Kratz A
  • Wefers AK
  • Huang K
  • Pajtler KW
  • Schweizer L
  • Stichel D
  • Olar A
  • Engel NW
  • Lindenberg K
  • Harter PN
  • Braczynski AK
  • Plate KH
  • Dohmen H
  • Garvalov BK
  • Coras R
  • Holsken A
  • Hewer E
  • Bewerunge-Hudler M
  • Schick M
  • Fischer R
  • Beschorner R
  • Schittenhelm J
  • Staszewski O
  • Wani K
  • Varlet P
  • Pages M
  • Temming P
  • Lohmann D
  • Selt F
  • Witt H
  • Milde T
  • Witt O
  • Aronica E
  • Giangaspero F
  • Rushing E
  • Scheurlen W
  • Geisenberger C
  • Rodriguez FJ
  • Becker A
  • Preusser M
  • Haberler C
  • Bjerkvig R
  • Cryan J
  • Farrell M
  • Deckert M
  • Hench J
  • Frank S
  • Serrano J
  • Kannan K
  • Tsirigos A
  • Bruck W
  • Hofer S
  • Brehmer S
  • Seiz-Rosenhagen M
  • Hanggi D
  • Hans V
  • Rozsnoki S
  • Hansford JR
  • Kohlhof P
  • Kristensen BW
  • Lechner M
  • Lopes B
  • Mawrin C
  • Ketter R
  • Kulozik A
  • Khatib Z
  • Heppner F
  • Koch A
  • Jouvet A
  • Keohane C
  • Muhleisen H
  • Mueller W
  • Pohl U
  • Prinz M
  • Benner A
  • Zapatka M
  • Gottardo NG
  • Driever PH
  • Kramm CM
  • Muller HL
  • Rutkowski S
  • von Hoff K
  • Fruhwald MC
  • Gnekow A
  • Fleischhack G
  • Tippelt S
  • Calaminus G
  • Monoranu CM
  • Perry A
  • Jones C
  • Jacques TS
  • Radlwimmer B
  • Gessi M
  • Pietsch T
  • Schramm J
  • Schackert G
  • Westphal M
  • Reifenberger G
  • Wesseling P
  • Weller M
  • Collins VP
  • Blumcke I
  • Bendszus M
  • Debus J
  • Huang A
  • Jabado N
  • Northcott PA
  • Paulus W
  • Gajjar A
  • Robinson GW
  • Taylor MD
  • Jaunmuktane Z
  • Ryzhova M
  • Platten M
  • Unterberg A
  • Wick W
  • Karajannis MA
  • Mittelbronn M
  • Acker T
  • Hartmann C
  • Aldape K
  • Schuller U
  • Buslei R
  • Lichter P
  • Kool M
  • Herold-Mende C
  • Ellison DW
  • Hasselblatt M
  • Snuderl M
  • Brandner S
  • Korshunov A
  • von Deimling A
  • Pfister SM.

Molecular profiling of microglia in steady state and under inflammatory conditions. (Doctoral thesis)

  • NORLUX Neuro-Oncology Laboratory
March 14, 2018
2018 Mar. Luxembourg: Université de Luxembourg 2018. 102 p.
By:
  • Sousa C.

Integrative computational network analysis reveals site-specific mediators of inflammation in Alzheimer's disease.

  • NORLUX Neuro-Oncology Laboratory
March 02, 2018
2018 Mar. Front Physiol.9:154.
By:
  • Ravichandran S
  • Michelucci A
  • Del Sol A.

Adaptive capacities of cancer cells in Glioblastoma. (Doctoral thesis)

  • NORLUX Neuro-Oncology Laboratory
January 17, 2018
2018 Jan. Luxembourg: Université de Luxembourg 2018. 330 p.
By:
  • Dirkse A.

Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation.

  • NORLUX Neuro-Oncology Laboratory
December 12, 2017
2017 Dec. Elife.6:e27444.
By:
  • Lapaquette P
  • Fritah S
  • Lhocine N
  • Andrieux A
  • Nigro G
  • Mounier J
  • Sansonetti P
  • Dejean A.

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Computational Biomedicine
December 01, 2017
2017 Dec. EMBO Mol Med.9(12):1681-1695.
By:
  • Fack F
  • Tardito S
  • Hochart G
  • Oudin A
  • Zheng L
  • Fritah S
  • Golebiewska A
  • Nazarov PV
  • Bernard A
  • Hau AC
  • Keunen O
  • Leenders W
  • Lund-Johansen M
  • Stauber J
  • Gottlieb E
  • Bjerkvig R
  • Niclou SP.

The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors.

  • NORLUX Neuro-Oncology Laboratory
November 17, 2017
2017 Nov. Nat Commun.8(1):1571.
By:
  • Boye K
  • Pujol N
  • I DA
  • Chen YP
  • Daubon T
  • Lee YZ
  • Dedieu S
  • Constantin M
  • Bello L
  • Rossi M
  • Bjerkvig R
  • Sue SC
  • Bikfalvi A
  • Billottet C.

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • Tumor Immunotherapy and Microenvironment
September 05, 2017
2017 Sep. Br J Cancer.117(6):813-825. Epub 2017 Aug 10.
By:
  • Abdul Rahim SA
  • Dirkse A
  • Oudin A
  • Schuster A
  • Bohler J
  • Barthelemy V
  • Muller A
  • Vallar L
  • Janji B
  • Golebiewska A
  • Niclou SP.

Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination.

  • NORLUX Neuro-Oncology Laboratory
September 05, 2017
2017 Sep. J Exp Clin Cancer Res.36(1):118.
By:
  • Zhang X
  • Xu R
  • Zhang C
  • Xu Y
  • Han M
  • Huang B
  • Chen A
  • Qiu C
  • Thorsen F
  • Prestegarden L
  • Bjerkvig R
  • Wang J
  • Li X.

MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1.

  • NORLUX Neuro-Oncology Laboratory
September 04, 2017
2017 Sep. J Cell Biol.216(9):2715-2729. Epub 2017 Jul 24.
By:
  • Hau AC
  • Grebbin BM
  • Agoston Z
  • Anders-Maurer M
  • Muller T
  • Gross A
  • Kolb J
  • Langer JD
  • Doring C
  • Schulte D.