Latest publications

Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors.

  • NORLUX Neuro-Oncology Laboratory
August 29, 2019
2019 Aug. Int J Mol Sci.20(17).
By:
  • Aasen SN
  • Parajuli H
  • Hoang T
  • Feng Z
  • Stokke K
  • Wang J
  • Roy K
  • Bjerkvig R
  • Knappskog S
  • Thorsen F.

Highlights of the inaugural ten - the launch of Neuro-Oncology Advances.

  • NORLUX Neuro-Oncology Laboratory
August 28, 2019
2019 Aug. Neurooncol Adv.1(1):vdz016.
By:
  • Nassiri F
  • Aldape K
  • Alhuwalia M
  • Brastianos P
  • Ducray F
  • Galldiks N
  • Kim A
  • Lamszus K
  • Mitchell D
  • Nabors LB
  • Nam DH
  • Natsume A
  • Ng HK
  • Niclou S
  • Sahm F
  • Short S
  • Walsh K
  • Wick W
  • Zadeh G.

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

  • Luxembourg Center of Neuropathology
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
July 01, 2019
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
By:
  • Zeiner PS
  • Preusse C
  • Golebiewska A
  • Zinke J
  • Iriondo A
  • Muller A
  • Kaoma T
  • Filipski K
  • Muller-Eschner M
  • Bernatz S
  • Blank AE
  • Baumgarten P
  • Ilina E
  • Grote A
  • Hansmann ML
  • Verhoff MA
  • Franz K
  • Feuerhake F
  • Steinbach JP
  • Wischhusen J
  • Stenzel W
  • Niclou SP
  • Harter PN
  • Mittelbronn M.

Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
July 01, 2019
2019 Jul. Neuro Oncol.21(7):890–900.
By:
  • Hossain JA
  • Latif MA
  • Ystaas LAR
  • Ninzima S
  • Riecken K
  • Muller A
  • Azuaje F
  • Joseph JV
  • Talasila KM
  • Ghimire J
  • Fehse B
  • Bjerkvig R
  • Miletic H.

The distinct roles of CXCR3 variants and their ligands in the tumor microenvironment.

  • Immuno-Pharmacology and Interactomics
  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
June 18, 2019
2019 Jun. Cells.8(6).
By:
  • Reynders N
  • Abboud D
  • Baragli A
  • Noman MZ
  • Rogister B
  • Niclou SP
  • Heveker N
  • Janji B
  • Hanson J
  • Szpakowska M
  • Chevigne A.

Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes.

  • NORLUX Neuro-Oncology Laboratory
June 04, 2019
2019 Jun. Oncotarget.10(38):3641-3653.
By:
  • Exner ND
  • Valenzuela JAC
  • Abou-El-Ardat K
  • Miletic H
  • Huszthy PC
  • Radehaus PM
  • Schrock E
  • Bjerkvig R
  • Kaderali L
  • Klink B
  • Nigro JM.

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Competence Center for Methodology and Statistics
  • Platform National Cytometry
April 16, 2019
2019 Apr. Nat Commun.10(1):1787.
By:
  • Dirkse A
  • Golebiewska A
  • Buder T
  • Nazarov PV
  • Muller A
  • Poovathingal S
  • Brons NHC
  • Leite S
  • Sauvageot N
  • Sarkisjan D
  • Seyfrid M
  • Fritah S
  • Stieber D
  • Michelucci A
  • Hertel F
  • Herold-Mende C
  • Azuaje F
  • Skupin A
  • Bjerkvig R
  • Deutsch A
  • Voss-Bohme A
  • Niclou SP.

Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
April 10, 2019
2019 Apr. Acta Neuropathol Commun.7(1):55.
By:
  • Sundstrom T
  • Prestegarden L
  • Azuaje F
  • Aasen SN
  • Rosland GV
  • Varughese JK
  • Bahador M
  • Bernatz S
  • Braun Y
  • Harter PN
  • Skaftnesmo KO
  • Ingham ES
  • Mahakian LM
  • Tam S
  • Tepper CG
  • Petersen K
  • Ferrara KW
  • Tronstad KJ
  • Lund-Johansen M
  • Beschorner R
  • Bjerkvig R
  • Thorsen F.

Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide.

  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
April 01, 2019
2019 Apr. Int J Cancer.144(7):1735-1745. Epub 2018 Dec 11.
By:
  • Johannessen TC
  • Hasan-Olive MM
  • Zhu H
  • Denisova O
  • Grudic A
  • Latif MA
  • Saed H
  • Varughese JK
  • Rosland GV
  • Yang N
  • Sundstrom T
  • Nordal A
  • Tronstad KJ
  • Wang J
  • Lund-Johansen M
  • Simonsen A
  • Janji B
  • Westermarck J
  • Bjerkvig R
  • Prestegarden L.

Irradiation to improve the response to immunotherapeutic agents in glioblastomas.

  • NORLUX Neuro-Oncology Laboratory
April 01, 2019
2019 Apr. Adv Radiat Oncol.4(2):268-282.
By:
  • Nesseler JP
  • Schaue D
  • McBride WH
  • Lee MH
  • Kaprealian T
  • Niclou SP
  • Nickers P.

A DNA repair and cell-cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications.

  • DNA Repair and Chemoresistance
  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
March 15, 2019
2019 Mar. Cancer Res.79(6):1226-1238. Epub 2019 Jan 23.
By:
  • Gobin M
  • Nazarov PV
  • Warta R
  • Timmer M
  • Reifenberger G
  • Felsberg J
  • Vallar L
  • Chalmers AJ
  • Herold-Mende CC
  • Goldbrunner R
  • Niclou SP
  • Van Dyck E.

Deciphering the complex role of thrombospondin-1 in glioblastoma development.

  • NORLUX Neuro-Oncology Laboratory
March 08, 2019
2019 Mar. Nat Commun.10(1):1146.
By:
  • Daubon T
  • Leon C
  • Clarke K
  • Andrique L
  • Salabert L
  • Darbo E
  • Pineau R
  • Guerit S
  • Maitre M
  • Dedieu S
  • Jeanne A
  • Bailly S
  • Feige JJ
  • Miletic H
  • Rossi M
  • Bello L
  • Falciani F
  • Bjerkvig R
  • Bikfalvi A.

Transcriptional and epigenetic mechanisms underlying astrocyte identity.

  • NORLUX Neuro-Oncology Laboratory
March 01, 2019
2019 Mar. Prog Neurobiol.174:36-52. Epub 2018 Dec 29.
By:
  • Pavlou MAS
  • Grandbarbe L
  • Buckley NJ
  • Niclou SP
  • Michelucci A.

Glioblastoma: a prognostic value of AMT-PET?

  • NORLUX Neuro-Oncology Laboratory
February 14, 2019
2019 Feb. Neuro Oncol.21(2):146-147.
By:
  • Bjerkvig R
  • Thorsen F.

Therapeutic effect of cabazitaxel and blood-brain barrier opening in a patient-derived glioblastoma model.

  • NORLUX Neuro-Oncology Laboratory
February 07, 2019
2019 Feb. Nanotheranostics.3(1):103-112.
By:
  • Sulheim E
  • Morch Y
  • Snipstad S
  • Borgos SE
  • Miletic H
  • Bjerkvig R
  • Davies CL
  • Aslund AKO.

The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity.

  • NORLUX Neuro-Oncology Laboratory
January 08, 2019
2019 Jan. Cell Metab.29(1):211-220 e5. Epub 2018 Oct 4.
By:
  • Dominguez-Andres J
  • Novakovic B
  • Li Y
  • Scicluna BP
  • Gresnigt MS
  • Arts RJW
  • Oosting M
  • Moorlag S
  • Groh LA
  • Zwaag J
  • Koch RM
  • Ter Horst R
  • Joosten LAB
  • Wijmenga C
  • Michelucci A
  • van der Poll T
  • Kox M
  • Pickkers P
  • Kumar V
  • Stunnenberg H
  • Netea MG.

RNAi/CRISPR Screens: from a Pool to a Valid Hit.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • DNA Repair and Chemoresistance
January 01, 2019
2019 Jan. Trends Biotechnol.37(1):38-55. Epub 2018 Aug 31.
By:
  • Schuster A
  • Erasimus H
  • Fritah S
  • Nazarov PV
  • van Dyck E
  • Niclou SP
  • Golebiewska A.

Iterative methods for fast reconstruction of undersampled dynamic contrast-enhanced MRI data. In World Congress on Medical Physics and Biomedical Engineering 2018. (Book Chapter)

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
January 01, 2019
2019 Jan. Ibbott GS, Lhotska L, Sukupova L and Lackovic I, eds. Singapore: Springer Verlag, 2019. p.267-271. (IFMBE, Vol. 68, N°1). ISBN 978-981-10-9034-9 (print); 978-981-10-9035-6 (online).
By:
  • Walner H
  • Bartoš M
  • Mangová M
  • Keunen O
  • Bjerkvig R
  • Jiřík R
  • Šorel M.

Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
November 01, 2018
2018 Nov. EMBO Rep.19(11). Epub 2018 Sep 11.
By:
  • Sousa C
  • Golebiewska A
  • Poovathingal SK
  • Kaoma T
  • Pires-Afonso Y
  • Martina S
  • Coowar D
  • Azuaje F
  • Skupin A
  • Balling R
  • Biber K
  • Niclou SP
  • Michelucci A.

Revival of the VEGF ligand family?

  • NORLUX Neuro-Oncology Laboratory
October 09, 2018
2018 Oct. Neuro Oncol.20(11):1421-1422.
By:
  • Niclou SP.