Latest publications

Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
March 01, 2020
2020 Mar. J Cell Mol Med.24(5):2847-2856. Epub 2019 Nov 28.
By:
  • Feng Z
  • Zhou W
  • Qi Q
  • Han M
  • Kong Y
  • Hu Y
  • Zhang Y
  • Huang B
  • Chen A
  • Zhang D
  • Li W
  • Zhang Q
  • Bjerkvig R
  • Wang J
  • Thorsen F
  • Li X.

Gender issues from the perspective of health-care professionals in Neuro-oncology: an EANO and EORTC Brain Tumor Group survey.

  • NORLUX Neuro-Oncology Laboratory
March 01, 2020
2020 Mar. Neurooncol Pract.7(2):249-259. Epub 2020 Jan 10.
By:
  • Le Rhun E
  • Weller M
  • Niclou SP
  • Short S
  • Piil K
  • Boele F
  • Rudà R
  • Theodorou M
  • Brandsma D
  • van den Bent M
  • Dirven L
  • on behalf of the EANO Women in Neuro-Oncology Committee.

Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity.

  • Proteomics of Cellular Signaling
  • Quantitative Biology Unit
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
February 19, 2020
2020 Feb. Sci Rep.10(1):2896.
By:
  • Rodius S
  • de Klein N
  • Jeanty C
  • Sanchez-Iranzo H
  • Crespo I
  • Ibberson M
  • Xenarios I
  • Dittmar G
  • Mercader N
  • Niclou SP
  • Azuaje F.

Suicide gene therapy for the treatment of high-grade glioma: past lessons, present trends, and future prospects.

  • NORLUX Neuro-Oncology Laboratory
  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
February 06, 2020
2020 Feb. Neurooncol Adv.2(1):vdaa013.
By:
  • Hossain JA
  • Marchini A
  • Fehse B
  • Bjerkvig R
  • Miletic H.

Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/beta-catenin signalling.

  • NORLUX Neuro-Oncology Laboratory
February 01, 2020
2020 Feb. Brain.143(2):512-530.
By:
  • Han M
  • Wang S
  • Fritah S
  • Wang X
  • Zhou W
  • Yang N
  • Ni S
  • Huang B
  • Chen A
  • Li G
  • Miletic H
  • Thorsen F
  • Bjerkvig R
  • Li X
  • Wang J.

Revealing and harnessing tumour-associated microglia/macrophage heterogeneity in glioblastoma.

  • Neuro-Immunology Group
  • NORLUX Neuro-Oncology Laboratory
January 21, 2020
2020 Jan. Int J Mol Sci.21(3):E689.
By:
  • Pires-Afonso Y
  • Niclou SP
  • Michelucci A.

Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
January 09, 2020
2020 Jan. EMBO Mol Med.12(1):e10924. Epub 2019 Nov 28.
By:
  • Han M
  • Wang S
  • Yang N
  • Wang X
  • Zhao W
  • Saed HS
  • Daubon T
  • Huang B
  • Chen A
  • Li G
  • Miletic H
  • Thorsen F
  • Bjerkvig R
  • Li X
  • Wang J.

PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1.

  • NORLUX Neuro-Oncology Laboratory
January 01, 2020
2020 Jan. Oncogene.39(5):1125-1139. Epub 2019 Oct 11.
By:
  • Ji J
  • Ding K
  • Luo T
  • Xu R
  • Zhang X
  • Huang B
  • Chen A
  • Zhang D
  • Miletic H
  • Bjerkvig R
  • Thorsen F
  • Wang J
  • Li X.

A new chance for EGFR inhibition in glioblastoma?

  • NORLUX Neuro-Oncology Laboratory
December 17, 2019
2019 Dec. Neuro Oncol.21(12):1487-1488.
By:
  • Johannessen TA
  • Bjerkvig R.

Mutant IDH1 differently affects redox state and metabolism in glial cells of normal and tumor origin.

  • NORLUX Neuro-Oncology Laboratory
December 16, 2019
2019 Dec. Cancers.11(12):2028.
By:
  • Biedermann J
  • Preussler M
  • Conde M
  • Peitzsch M
  • Richter S
  • Wiedemuth R
  • Abou-El-Ardat K
  • Kruger A
  • Meinhardt M
  • Schackert G
  • Leenders WP
  • Herold-Mende C
  • Niclou SP
  • Bjerkvig R
  • Eisenhofer G
  • Temme A
  • Seifert M
  • Kunz-Schughart LA
  • Schrock E
  • Klink B.

Spatially regularized estimation of the tissue homogeneity model parameters in DCE-MRI using proximal minimization.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
December 01, 2019
2019 Dec. Magn Reson Med.82(6):2257-2272. Epub 2019 Jul 17.
By:
  • Bartos M
  • Rajmic P
  • Sorel M
  • Mangova M
  • Keunen O
  • Jirik R.

Longitudinal molecular trajectories of diffuse glioma in adults.

  • NORLUX Neuro-Oncology Laboratory
December 01, 2019
2019 Dec. Nature.576(7785):112-120. Epub 2019 Nov 20.
By:
  • Barthel FP
  • Johnson KC
  • Varn FS
  • Moskalik AD
  • Tanner G
  • Kocakavuk E
  • Anderson KJ
  • Abiola O
  • Aldape K
  • Alfaro KD
  • Alpar D
  • Amin SB
  • Ashley DM
  • Bandopadhayay P
  • Barnholtz-Sloan JS
  • Beroukhim R
  • Bock C
  • Brastianos PK
  • Brat DJ
  • Brodbelt AR
  • Bruns AF
  • Bulsara KR
  • Chakrabarty A
  • Chakravarti A
  • Chuang JH
  • Claus EB
  • Cochran EJ
  • Connelly J
  • Costello JF
  • Finocchiaro G
  • Fletcher MN
  • French PJ
  • Gan HK
  • Gilbert MR
  • Gould PV
  • Grimmer MR
  • Iavarone A
  • Ismail A
  • Jenkinson MD
  • Khasraw M
  • Kim H
  • Kouwenhoven MCM
  • LaViolette PS
  • Li M
  • Lichter P
  • Ligon KL
  • Lowman AK
  • Malta TM
  • Mazor T
  • McDonald KL
  • Molinaro AM
  • Nam DH
  • Nayyar N
  • Ng HK
  • Ngan CY
  • Niclou SP
  • Niers JM
  • Noushmehr H
  • Noorbakhsh J
  • Ormond DR
  • Park CK
  • Poisson LM
  • Rabadan R
  • Radlwimmer B
  • Rao G
  • Reifenberger G
  • Sa JK
  • Schuster M
  • Shaw BL
  • Short SC
  • Smitt PAS
  • Sloan AE
  • Smits M
  • Suzuki H
  • Tabatabai G
  • Van Meir EG
  • Watts C
  • Weller M
  • Wesseling P
  • Westerman BA
  • Widhalm G
  • Woehrer A
  • Yung WKA
  • Zadeh G
  • Huse JT
  • De Groot JF
  • Stead LF
  • Verhaak RGW
  • Glass Consortium.

Long Noncoding RNA SChLAP1 forms a Growth-Promoting Complex with HNRNPL in human glioblastoma through stabilization of ACTN4 and activation of NF-κB signaling.

  • NORLUX Neuro-Oncology Laboratory
November 15, 2019
2019 Nov. Clin Cancer Res.25(22):6868-6881. Epub 2019 Sep 6.
By:
  • Ji J
  • Xu R
  • Ding K
  • Bao G
  • Zhang X
  • Huang B
  • Martinez A
  • Wang X
  • Li G
  • Miletic H
  • Thorsen F
  • Bjerkvig R
  • Xiang L
  • Han B
  • Chen A
  • Li X
  • Wang J.

Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier.

  • Translational Radiomics
  • NORLUX Neuro-Oncology Laboratory
November 01, 2019
2019 Nov. Mol Cancer Ther.18(11):2171-2181. Epub 2019 Aug 29.
By:
  • Aasen SN
  • Espedal H
  • Holte CF
  • Keunen O
  • Karlsen TV
  • Tenstad O
  • Maherally Z
  • Miletic H
  • Hoang T
  • Eikeland AV
  • Baghirov H
  • Olberg DE
  • Pilkington GJ
  • Sarkar G
  • Jenkins RB
  • Sundstrom T
  • Bjerkvig R
  • Thorsen F.

The implication of anti-angiogenic treatment of malignancies on human metabolism. In Tumor angiogenesis: A key target for cancer therapy. (Book Chapter)

  • NORLUX Neuro-Oncology Laboratory
October 01, 2019
2019 Oct. Marmé D, ed. Springer, 2019. p.661-672. ISBN 978-3-319-33671-8.
By:
  • Obad N
  • Bjerkvig R.

The invasive proteome of glioblastoma revealed by laser-capture microdissection.

  • NORLUX Neuro-Oncology Laboratory
September 28, 2019
2019 Sep. Neurooncol Adv.1(1):vdz029.
By:
  • Daubon T
  • Guyon J
  • Raymond AA
  • Dartigues B
  • Rudewicz J
  • Ezzoukhry Z
  • Dupuy JW
  • Herbert JMJ
  • Saltel F
  • Bjerkvig R
  • Nikolski M
  • Bikfalvi A.

The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein-protein interaction in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Immuno-Pharmacology and Interactomics
September 06, 2019
2019 Sep. Neurooncol Adv.1(1):vdz024.
By:
  • Neirinckx V
  • Hau AC
  • Schuster A
  • Fritah S
  • Tiemann K
  • Klein E
  • Nazarov PV
  • Matagne A
  • Szpakowska M
  • Meyrath M
  • Chevigne A
  • Schmidt MHH
  • Niclou SP.

Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors.

  • NORLUX Neuro-Oncology Laboratory
August 29, 2019
2019 Aug. Int J Mol Sci.20(17).
By:
  • Aasen SN
  • Parajuli H
  • Hoang T
  • Feng Z
  • Stokke K
  • Wang J
  • Roy K
  • Bjerkvig R
  • Knappskog S
  • Thorsen F.

Highlights of the inaugural ten - the launch of Neuro-Oncology Advances.

  • NORLUX Neuro-Oncology Laboratory
August 28, 2019
2019 Aug. Neurooncol Adv.1(1):vdz016.
By:
  • Nassiri F
  • Aldape K
  • Alhuwalia M
  • Brastianos P
  • Ducray F
  • Galldiks N
  • Kim A
  • Lamszus K
  • Mitchell D
  • Nabors LB
  • Nam DH
  • Natsume A
  • Ng HK
  • Niclou S
  • Sahm F
  • Short S
  • Walsh K
  • Wick W
  • Zadeh G.

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

  • Luxembourg Center of Neuropathology
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
July 01, 2019
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
By:
  • Zeiner PS
  • Preusse C
  • Golebiewska A
  • Zinke J
  • Iriondo A
  • Muller A
  • Kaoma T
  • Filipski K
  • Muller-Eschner M
  • Bernatz S
  • Blank AE
  • Baumgarten P
  • Ilina E
  • Grote A
  • Hansmann ML
  • Verhoff MA
  • Franz K
  • Feuerhake F
  • Steinbach JP
  • Wischhusen J
  • Stenzel W
  • Niclou SP
  • Harter PN
  • Mittelbronn M.