Latest publications

Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors.

  • NORLUX Neuro-Oncology Laboratory
  • Neuro-Immunology Group
  • Translational Radiomics
June 18, 2021
2021 Jun. STAR Protoc.2(2):100534.
By:
  • Oudin A
  • Baus V
  • Barthelemy V
  • Fabian C
  • Klein E
  • Dieterle M
  • Wantz M
  • Hau AC
  • Dording C
  • Bernard A
  • Michelucci A
  • Yabo YA
  • Kanli G
  • Keunen O
  • Bjerkvig R
  • Niclou SP
  • Golebiewska A.

Novel facets of glioma invasion.

  • NORLUX Neuro-Oncology Laboratory
May 09, 2021
2021 May. Int Rev Cell Mol Biol.360:33-64. Epub 2020 Oct 17.
By:
  • Fabian C
  • Han M
  • Bjerkvig R
  • Niclou SP.

Identifying and targeting the metabolic escape mechanisms in IDH mutant gliomas. (Doctoral thesis)

  • NORLUX Neuro-Oncology Laboratory
April 29, 2021
2021 Apr. Luxembourg: Université de Luxembourg 2021.
By:
  • Cano-Galiano A.

Turning strength into weakness: protein degradation and autophagy as therapeutic targets in Glioblastoma?

  • NORLUX Neuro-Oncology Laboratory
April 17, 2021
2021 Apr. Neuro Oncol. Online ahead of print.
By:
  • Niclou SP
  • Golebiewska A.

Cystathionine-γ-lyase drives antioxidant defense in cysteine-restricted IDH1 mutant astrocytomas.

  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
  • Quantitative Biology Unit
  • Cancer Metabolism Group
April 09, 2021
2021 Apr. Neurooncol Adv. In press.
By:
  • Cano-Galiano A
  • Oudin A
  • Fack F
  • Allega M-F
  • Sumpton D
  • Martinez-Garcia E
  • Dittmar G
  • Hau A-C
  • De Falco A
  • Herold-Mende C
  • Bjerkvig R
  • Meiser J
  • Tardito S
  • Niclou SP.

Chromosome Y pericentric heterochromatin is a primary target of HSF1 in male cells.

  • NORLUX Neuro-Oncology Laboratory
March 01, 2021
2021 Mar. Chromosoma.130(1):53-60. Epub 2021 Feb 6.
By:
  • Penin J
  • Dufour S
  • Faure V
  • Fritah S
  • Seigneurin-Berny D
  • Col E
  • Verdel A
  • Vourc'h C.

Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening.

  • Transversal Translational Medicine
  • NORLUX Neuro-Oncology Laboratory
January 14, 2021
2021 Jan. Sci Rep.11(1):1439.
By:
  • Boussaad I
  • Cruciani G
  • Bolognin S
  • Antony P
  • Dording CM
  • Kwon YJ
  • Heutink P
  • Fava E
  • Schwamborn JC
  • Kruger R.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts.

  • NORLUX Neuro-Oncology Laboratory
January 01, 2021
2021 Jan. Nat Genet.53(1):86-99. Epub 2021 Jan 7.
By:
  • Woo XY
  • Giordano J
  • Srivastava A
  • Zhao ZM
  • Lloyd MW
  • de Bruijn R
  • Suh YS
  • Patidar R
  • Chen L
  • Scherer S
  • Bailey MH
  • Yang CH
  • Cortes-Sanchez E
  • Xi Y
  • Wang J
  • Wickramasinghe J
  • Kossenkov AV
  • Rebecca VW
  • Sun H
  • Mashl RJ
  • Davies SR
  • Jeon R
  • Frech C
  • Randjelovic J
  • Rosains J
  • Galimi F
  • Bertotti A
  • Lafferty A
  • O'Farrell AC
  • Modave E
  • Lambrechts D
  • Ter Brugge P
  • Serra V
  • Marangoni E
  • El Botty R
  • Kim H
  • Kim JI
  • Yang HK
  • Lee C
  • Dean DA
  • 2nd
  • Davis-Dusenbery B
  • Evrard YA
  • Doroshow JH
  • Welm AL
  • Welm BE
  • Lewis MT
  • Fang B
  • Roth JA
  • Meric-Bernstam F
  • Herlyn M
  • Davies MA
  • Ding L
  • Li S
  • Govindan R
  • Isella C
  • Moscow JA
  • Trusolino L
  • Byrne AT
  • Jonkers J
  • Bult CJ
  • Medico E
  • Chuang JH
  • Pdxnet Consortium
  • EurOPDX Consortium (Golebiewska A. and Niclou S.P. as collaborators for Luxembourg).

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

  • NORLUX Neuro-Oncology Laboratory
  • Tumor Immunotherapy and Microenvironment
January 01, 2021
2021 Jan. Autophagy.17(1):1-382. Epub 2021 Feb 8.
By:
  • Klionsky DJ
  • Abdel-Aziz AK
  • Abdelfatah S
  • Abdellatif M
  • Abdoli A
  • Abel S
  • et al
  • Golebiewska A. (Author for LIH)
  • Janji B. (Author for LIH).

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Quantitative Biology Unit
  • Proteomics of Cellular Signaling
December 11, 2020
2020 Dec. Nat Commun.11(1):6366.
By:
  • Schuster A
  • Klein E
  • Neirinckx V
  • Knudsen AM
  • Fabian C
  • Hau AC
  • Dieterle M
  • Oudin A
  • Nazarov PV
  • Golebiewska A
  • Muller A
  • Perez-Hernandez D
  • Rodius S
  • Dittmar G
  • Bjerkvig R
  • Herold-Mende C
  • Klink B
  • Kristensen BW
  • Niclou SP.

Glioblastoma organoids: Pre-clinical applications and challenges in the context of immunotherapy.

  • NORLUX Neuro-Oncology Laboratory
December 08, 2020
2020 Dec. Front Oncol.10:604121.
By:
  • Klein E
  • Hau AC
  • Oudin A
  • Golebiewska A
  • Niclou SP.

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.

New hints towards a precision medicine strategy for IDH wild-type glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
December 01, 2020
2020 Dec. Ann Oncol.31(12):1679-1692. Epub 2020 Sep 9.
By:
  • White K
  • Connor K
  • Clerkin J
  • Murphy BM
  • Salvucci M
  • O'Farrell AC
  • Rehm M
  • O'Brien D
  • Prehn JHM
  • Niclou SP
  • Lamfers MLM
  • Verreault M
  • Idbaih A
  • Verhaak R
  • Golebiewska A
  • Byrne AT.

Temozolomide-induced RNA interactome uncovers novel lncRNA regulatory loops in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Quantitative Biology Unit
  • DNA Repair and Chemoresistance
September 10, 2020
2020 Sep. Cancers.12(9).
By:
  • Fritah S
  • Muller A
  • Jiang W
  • Mitra R
  • Sarmini M
  • Dieterle M
  • Golebiewska A
  • Ye T
  • Van Dyck E
  • Herold-Mende C
  • Zhao Z
  • Azuaje F
  • Niclou SP.

Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
July 30, 2020
2020 Jul. F1000Res.7:1906.
By:
  • Azuaje F
  • Kaoma T
  • Jeanty C
  • Nazarov PV
  • Muller A
  • Kim SY
  • Dittmar G
  • Golebiewska A
  • Niclou SP.

Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?

  • Translational Radiomics
  • NORLUX Neuro-Oncology Laboratory
July 01, 2020
2020 Jul. Neuro Oncol.22(7):903-904.
By:
  • Keunen O
  • Niclou SP.

Identification of a blood-based protein biomarker panel for lung cancer detection.

  • Personalized Therapy Discovery
  • Competence Center for Methodology and Statistics
  • Multiomics Data Science
  • Quantitative Biology Unit
  • NORLUX Neuro-Oncology Laboratory
June 19, 2020
2020 Jun. Cancers.12(6):E1629.
By:
  • El-Khoury V
  • Schritz A
  • Kim SY
  • Lesur A
  • Sertamo K
  • Bernardin F
  • Petritis K
  • Pirrotte P
  • Selinsky C
  • Whiteaker JR
  • Zhang H
  • Kennedy JJ
  • Lin C
  • Lee LW
  • Yan P
  • Tran NL
  • Inge LJ
  • Chalabi K
  • Decker G
  • Bjerkvig R
  • Paulovich AG
  • Berchem G
  • Kim YJ.

A validated prognostic nomogram for patients with newly diagnosed lower-grade gliomas in a large-scale Asian cohort.

  • NORLUX Neuro-Oncology Laboratory
May 01, 2020
2020 May. Neuro Oncol.22(5):729-731.
By:
  • Han MZ
  • Huang B
  • Ni SL
  • Wang J
  • Li XG
  • Bjerkvig R.

Dual blockade of STAT3 and EGFR: a key to unlock drug resistance in glioblastoma?

  • NORLUX Neuro-Oncology Laboratory
April 15, 2020
2020 Apr. Neuro Oncol.22(4):440-441.
By:
  • Fritah S
  • Niclou SP.

BCL2L15 (BCL2-like 15).

  • NORLUX Neuro-Oncology Laboratory
April 01, 2020
2020 Apr. Atlas of Genetics and Cytogenetics in Oncology and Haematology.24(12):445-450.
By:
  • Artemaki PI
  • Pavlou MAS
  • Kontos CK.