Latest publications

Integrative approaches for analysis of mRNA and microRNA high-throughput data.

  • Multiomics Data Science
January 26, 2021
2021 Jan. Comput Struct Biotechnol J. In Press.
By:
  • Nazarov PV
  • Kreis S.

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Quantitative Biology Unit
  • Proteomics of Cellular Signaling
December 11, 2020
2020 Dec. Nat Commun.11(1):6366.
By:
  • Schuster A
  • Klein E
  • Neirinckx V
  • Knudsen AM
  • Fabian C
  • Hau AC
  • Dieterle M
  • Oudin A
  • Nazarov PV
  • Golebiewska A
  • Muller A
  • Perez-Hernandez D
  • Rodius S
  • Dittmar G
  • Bjerkvig R
  • Herold-Mende C
  • Klink B
  • Kristensen BW
  • Niclou SP.

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.

Systematic transcriptional profiling of responses to STAT1- and STAT3-activating cytokines in different cancer types.

  • Multiomics Data Science
  • Quantitative Biology Unit
November 06, 2020
2020 Nov. J Mol Biol.432(22):5902-5919. Epub 2020 Sep 18.
By:
  • Kirchmeyer M
  • Servais F
  • Ginolhac A
  • Nazarov PV
  • Margue C
  • Philippidou D
  • Nicot N
  • Behrmann I
  • Haan C
  • Kreis S.

Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz.

  • Multiomics Data Science
  • Computational Biomedicine
October 01, 2020
2020 Oct. Nat Protoc.15(10):3240-3263. Epub 2020 Sep 25.
By:
  • Scherer M
  • Nazarov PV
  • Toth R
  • Sahay S
  • Kaoma T
  • Maurer V
  • Vedeneev N
  • Plass C
  • Lengauer T
  • Walter J
  • Lutsik P.

Community assessment of the predictability of cancer protein and phosphoprotein levels from genomics and transcriptomics.

  • Multiomics Data Science
  • Quantitative Biology Unit
August 26, 2020
2020 Aug. Cell Syst.11(2):186-195 e9. Epub 2020 Jul 24.
By:
  • Yang M
  • Petralia F
  • Li Z
  • Li H
  • Ma W
  • Song X
  • Kim S
  • Lee H
  • Yu H
  • Lee B
  • Bae S
  • Heo E
  • Kaczmarczyk J
  • Stępniak P
  • Warchoł M
  • Yu T
  • Calinawan AP
  • Boutros PC
  • Payne SH
  • Reva B
  • NCI-CPTAC-DREAM Consortium (Azuaje F. KT
  • Kim S.
  • Muller A.
  • Nazarov P.
  • Tranchevent L. as collaborators)
  • Boja E
  • Rodriguez H
  • Stolovitzky G
  • Guan Y
  • Kang J
  • Wang P
  • Fenyö D
  • Saez-Rodriguez J.

Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.

  • Tumor Immunotherapy and Microenvironment
  • Multiomics Data Science
  • Integrated BioBank of Luxembourg
  • Luxembourg Center of Neuropathology
August 01, 2020
2020 Aug. Autophagy.16(8):1436-1452. Epub 2019 Nov 27.
By:
  • Qureshi-Baig K
  • Kuhn D
  • Viry E
  • Pozdeev VI
  • Schmitz M
  • Rodriguez F
  • Ullmann P
  • Koncina E
  • Nurmik M
  • Frasquilho S
  • Nazarov PV
  • Zuegel N
  • Boulmont M
  • Karapetyan Y
  • Antunes L
  • Val D
  • Mittelbronn M
  • Janji B
  • Haan S
  • Letellier E.

Independent component analysis of cancer transcriptomes: optimization of parameters and improvement of interpretability. In Computer Technologies and Data Analysis (CTDA'2020) : Materials of II International Scientific-Practical Conference, Minsk, 23-24 April, 2020. (Book Chapter)

  • Multiomics Data Science
July 09, 2020
2020 Jul. Bishkek VA and Skakun V, eds. Minsk: BSU, 2020. p.170-173. ISBN 978-985-566-942-6.
By:
  • Chepeleva M
  • Kakoichankava A
  • Yatskou MM
  • Nazarov PV.

Deconvolution of “big data” in cancer genomics: from pancancer level to single cells. In Computer Technologies and Data Analysis (CTDA'2020) : Materials of II International Scientific-Practical Conference, Minsk, 23-24 April, 2020. (Book Chapter)

  • Multiomics Data Science
  • Computational Biomedicine
  • Quantitative Biology Unit
July 09, 2020
2020 Jul. Bishkek VA and Skakun V, eds. Minsk: BSU, 2020. p.7-11. ISBN 978-985-566-942-6.
By:
  • Chepeleva M
  • Wang Y
  • Kakoichankava A
  • Muller A
  • Kaoma T
  • Nazarov PV.

Identification of a blood-based protein biomarker panel for lung cancer detection.

  • Personalized Therapy Discovery
  • Competence Center for Methodology and Statistics
  • Multiomics Data Science
  • Quantitative Biology Unit
  • NORLUX Neuro-Oncology Laboratory
June 19, 2020
2020 Jun. Cancers.12(6):E1629.
By:
  • El-Khoury V
  • Schritz A
  • Kim SY
  • Lesur A
  • Sertamo K
  • Bernardin F
  • Petritis K
  • Pirrotte P
  • Selinsky C
  • Whiteaker JR
  • Zhang H
  • Kennedy JJ
  • Lin C
  • Lee LW
  • Yan P
  • Tran NL
  • Inge LJ
  • Chalabi K
  • Decker G
  • Bjerkvig R
  • Paulovich AG
  • Berchem G
  • Kim YJ.

Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software.

  • Computational Biomedicine
  • Multiomics Data Science
January 13, 2020
2020 Jan. BMC Bioinformatics.21(1):16.
By:
  • Decamps C
  • Prive F
  • Bacher R
  • Jost D
  • Waguet A
  • Hadaca consortium (Kaoma T and Nazarov P as collaborators)
  • Houseman EA
  • Lurie E
  • Lutsik P
  • Milosavljevic A
  • Scherer M
  • Blum MGB
  • Richard M.

Connecting histopathology imaging and proteomics in kidney cancer through machine learning.

  • Multiomics Data Science
  • Proteomics of Cellular Signaling
September 25, 2019
2019 Sep. J Clin Med.8(10).
By:
  • Azuaje F
  • Kim SY
  • Perez Hernandez D
  • Dittmar G.

Deconvolution of transcriptomes and miRNomes by independent component analysis provides insights into biological processes and clinical outcomes of melanoma patients.

  • Multiomics Data Science
  • Computational Biomedicine
  • Proteomics of Cellular Signaling
September 18, 2019
2019 Sep. BMC Med Genomics.12(1):132.
By:
  • Nazarov PV
  • Wienecke-Baldacchino AK
  • Zinovyev A
  • Czerwinska U
  • Muller A
  • Nashan D
  • Dittmar G
  • Azuaje F
  • Kreis S.

Independent component analysis for unraveling the complexity of cancer omics datasets.

  • Multiomics Data Science
September 07, 2019
2019 Sep. Int J Mol Sci.20(18).
By:
  • Sompairac N
  • Nazarov PV
  • Czerwinska U
  • Cantini L
  • Biton A
  • Molkenov A
  • Zhumadilov Z
  • Barillot E
  • Radvanyi F
  • Gorban A
  • Kairov U
  • Zinovyev A.

The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein-protein interaction in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Immuno-Pharmacology and Interactomics
September 06, 2019
2019 Sep. Neurooncol Adv.1(1):vdz024.
By:
  • Neirinckx V
  • Hau AC
  • Schuster A
  • Fritah S
  • Tiemann K
  • Klein E
  • Nazarov PV
  • Matagne A
  • Szpakowska M
  • Meyrath M
  • Chevigne A
  • Schmidt MHH
  • Niclou SP.

Power-law behavior of the alternative splicing of exons in human transcriptome.

  • Multiomics Data Science
September 02, 2019
2019 Sep. Annu Res Rev Biol.32(6):1-13.
By:
  • Grinev VV
  • Nazarov PV
  • Klimov EA.

Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity.

  • Multiomics Data Science
February 18, 2019
2019 Feb. Cancer Lett.450:32-41. Epub 2019 Feb 18.
By:
  • Ullmann P
  • Nurmik M
  • Schmitz M
  • Rodriguez F
  • Weiler J
  • Qureshi-Baig K
  • Felten P
  • Nazarov PV
  • Nicot N
  • Zuegel N
  • Haan S
  • Letellier E.

The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by alpha-PD-L1 or alpha-IL6 antibodies.

  • Multiomics Data Science
November 01, 2018
2018 Nov. J Leukoc Biol.104(5):969-985. Epub 2018 Jul 24.
By:
  • Rolvering C
  • Zimmer AD
  • Ginolhac A
  • Margue C
  • Kirchmeyer M
  • Servais F
  • Hermanns HM
  • Hergovits S
  • Nazarov PV
  • Nicot N
  • Kreis S
  • Haan S
  • Behrmann I
  • Haan C.

Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines.

  • Multiomics Data Science
March 01, 2017
2017 Mar. Biochim Biophys Acta-Mol Cell Res.1864(3):516-526. Epub 2016 Dec 9.
By:
  • Rolvering C
  • Zimmer AD
  • Kozar I
  • Hermanns HM
  • Letellier E
  • Vallar L
  • Nazarov PV
  • Nicot N
  • Ginolhac A
  • Haan S
  • Behrmann I
  • Haan C.

What do we learn from spheroid culture systems? Insights from tumorspheres derived from primary colon cancer tissue.

  • Integrated BioBank of Luxembourg
  • Multiomics Data Science
January 08, 2016
2016 Jan. PLoS One.11(1):e0146052.
By:
  • Qureshi-Baig K
  • Ullmann P
  • Rodriguez F
  • Frasquilho S
  • Nazarov PV
  • Haan S
  • Letellier E.