Guy Berchem

Latest publications

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • National Cytometry Platform
  • Tumor Microenvironment
  • NORLUX-Glioma Biology
  • Allergy and Clinical Immunology
February 13, 2018
2018 Feb. Blood. [Epub ahead of print].
By:
  • Wierz M
  • Pierson S
  • Guyonnet L
  • Viry E
  • Lequeux A
  • Oudin A
  • Niclou SP
  • Ollert M
  • Berchem G
  • Janji B
  • Guerin C
  • Paggetti J
  • Moussay E.

Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield.

  • Tumor Microenvironment
January 25, 2018
2018 Jan. Autophagy.1-7. [Epub ahead of print].
By:
  • Noman MZ
  • Berchem G
  • Janji B.

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
  • National Cytometry Platform
October 31, 2017
2017 Oct. Proc Natl Acad Sci U S A.114(44):E9271-E9279. Epub 2017 Oct 16.
By:
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Noman MZ
  • Viry E
  • Moussay E
  • Van Moer K
  • Kreis S
  • Guerin C
  • Buart S
  • Robert C
  • Borg C
  • Vielh P
  • Chouaib S
  • Berchem G
  • Janji B.

Activation of NK cells and disruption of PD-L1/PD-1 axis: two different ways for lenalidomide to block myeloma progression.

  • Tumor Microenvironment
April 04, 2017
2017 Apr. Oncotarget.8(14):24031-24044.
By:
  • Giuliani M
  • Janji B
  • Berchem G.

The critical role of hypoxia in tumor-mediated immunosuppression. In Hypoxia and Human Diseases. (Book Chapter)

  • Tumor Microenvironment
February 01, 2017
2017 Feb. Zheng J, ed. Intech, 2017. p.349-364. ISBN 978-953-51-2895-3.
By:
  • Aouali N
  • Bosseler M
  • Sauvage D
  • Van Moer K
  • Berchem G
  • Janji B.

Randomized phase II study of cabazitaxel versus methotrexate in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck previously treated with platinum-based therapy.

  • Tumor Microenvironment
December 01, 2016
2016 Dec. Oncologist.21(12):1416-e17. Epub 2016 Nov 30.
By:
  • Machiels JP
  • Van Maanen A
  • Vandenbulcke JM
  • Filleul B
  • Seront E
  • Henry S
  • D'Hondt L
  • Lonchay C
  • Holbrechts S
  • Boegner P
  • Brohee D
  • Dequanter D
  • Louviaux I
  • Sautois B
  • Whenham N
  • Berchem G
  • Vanderschueren B
  • Fontaine C
  • Schmitz S
  • Gillain A
  • Schoonjans J
  • Rottey S.

Hijacker of the antitumor immune response: autophagy is showing its worst facet.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
November 18, 2016
2016 Nov. Front Oncol.6(246).
By:
  • Viry E
  • Noman MZ
  • Arakelian T
  • Lequeux A
  • Chouaib S
  • Berchem G
  • Moussay E
  • Paggetti J
  • Janji B.

miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function.

  • Tumor Microenvironment
September 28, 2016
2016 Sep. Cancer Lett.380(1):257-62. Epub 2015 Oct 30.
By:
  • Noman MZ
  • Janji B
  • Berchem G
  • Chouaib S.

The multifaceted role of autophagy in tumor evasion from immune surveillance.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
April 05, 2016
2016 Apr. Oncotarget.7(14):17591-607.
By:
  • Janji B
  • Viry E
  • Moussay E
  • Paggetti J
  • Arakelian T
  • Mgrditchian T
  • Messai Y
  • Noman MZ
  • Van Moer K
  • Hasmim M
  • Mami-Chouaib F
  • Berchem G
  • Chouaib S.

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-beta and miR23a transfer.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
April 01, 2016
2016 Apr. OncoImmunology.5(4):e1062968. Epub 2015 Jun 24.
By:
  • Berchem G
  • Noman MZ
  • Bosseler M
  • Paggetti J
  • Baconnais S
  • Le Cam E
  • Nanbakhsh A
  • Moussay E
  • Mami-Chouaib F
  • Janji B
  • Chouaib S.

Prospective evaluation of first-Line erlotinib in advanced Non-Small Cell Lung Cancer (NSCLC) carrying an activating EGFR mutation: A multicenter academic phase II study in Caucasian patients (FIELT).

  • Tumor Microenvironment
March 31, 2016
2016 Mar. PLoS One.11(3):e0147599.
By:
  • De Greve J
  • Van Meerbeeck J
  • Vansteenkiste JF
  • Decoster L
  • Meert AP
  • Vuylsteke P
  • Focan C
  • Canon JL
  • Humblet Y
  • Berchem G
  • Colinet B
  • Galdermans D
  • Bosquee L
  • Vermeij J
  • Dewaele A
  • Geers C
  • Schallier D
  • Teugels E.

CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis.

  • Cytoskeleton and Cancer Progression
  • NORLUX-Glioma Biology
  • Tumor Microenvironment
March 22, 2016
2016 Mar. Oncotarget.7(12):13688-705.
By:
  • Hoffmann C
  • Mao X
  • Dieterle M
  • Moreau F
  • Al Absi A
  • Steinmetz A
  • Oudin A
  • Berchem G
  • Janji B
  • Thomas C.

Autophagy Activation in the Tumor Microenvironment: A Major Process in Shaping the Antitumor Immune Response. In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 1st ed. (Book Chapter)

  • Tumor Microenvironment
  • Tumor Stroma Interactions
February 25, 2016
2016 Feb. San Diego: Academic Press, 2016. p.267-290. (Vol. 8). ISBN 978-0-12-802937-4.
By:
  • Janji B
  • Viry E
  • Mgrditchian T
  • Arakelian T
  • Medves S
  • Berchem G.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

  • Clinical Proteomics
  • Tumor Microenvironment
January 02, 2016
2016 Jan. Autophagy.12(1):1-222.
By:
  • Klionsky D
  • Abdelmohsenn K
  • Abe A
  • Abedin M
  • et al (incl. El-Khoury V Janji B and Berchem G).

Autophagy regulation of the tumor immunity: An old housekeeper for a new function. In Cell Death - Autophagy, Necrosis and Apoptosis. (Book Chapter)

  • Tumor Microenvironment
  • Tumor Stroma Interactions
December 16, 2015
2015 Dec. Ntuli DT, ed. Rijeka: InTech, 2015. p.37-61. ISBN 978-953-51-2236-4.
By:
  • Arakelian T
  • Mgrditchian T
  • Viry E
  • Van Moer K
  • Paggetti J
  • Berchem G
  • Chouaib S
  • Janji B.

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.

  • Tumor Stroma Interactions
  • Tumor Microenvironment
  • Discovery Proteomics
  • Clinical Proteomics
August 27, 2015
2015 Aug. Blood.126(9):1106-17. Epub 2015 Jun 22.
By:
  • Paggetti J
  • Haderk F
  • Seiffert M
  • Janji B
  • Distler U
  • Ammerlaan W
  • Kim YJ
  • Adam J
  • Lichter P
  • Solary E
  • Berchem G
  • Moussay E.

Screening protein isoforms predictive for cancer using immuno-affinity capture and fast LC-MS in PRM mode.

  • Discovery Proteomics
  • Clinical Proteomics
  • Tumor Microenvironment
August 01, 2015
2015 Aug. Proteomics Clin Appl.9(7-8):695-705. Epub 2015 Mar 30.
By:
  • Lesur A
  • Ancheva L
  • Kim YJ
  • Berchem G
  • van Oostrum J
  • Domon B.

Epigenetic activity of peroxisome proliferator-activated receptor gamma agonists increases the anticancer effect of histone deacetylase inhibitors on multiple myeloma cells.

  • Tumor Microenvironment
  • In vivo imaging facility
  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
June 19, 2015
2015 Jun. PLoS One.10(6):e0130339.
By:
  • Aouali N
  • Broukou A
  • Bosseler M
  • Keunen O
  • Schlesser V
  • Janji B
  • Palissot V
  • Stordeur P
  • Berchem G.

First-line crizotinib versus chemotherapy in ALK-positive lung cancer.

  • Tumor Microenvironment
December 04, 2014
2014 Dec. N Engl J Med.371(23):2167-77.
By:
  • Solomon BJ
  • Mok T
  • Kim DW
  • Wu YL
  • Nakagawa K
  • Mekhail T
  • Felip E
  • Cappuzzo F
  • Paolini J
  • Usari T
  • Iyer S
  • Reisman A
  • Wilner KD
  • Tursi J
  • Blackhall F
  • PROFILE 1014 Investigators (Berchem G as collaborator for this project).

Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
  • Cytoskeleton and Cancer Progression
November 20, 2014
2014 Nov. J Imm Res.1(2):7.
By:
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Viry E
  • Al-Absi A
  • Medves S
  • Moussay E
  • Berchem G
  • Thomas C
  • Janji B.