Laurent Vallar

Latest publications

Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer.

  • Bioinformatics and Modelling
  • Genomics Center
October 06, 2017
2017 Oct. Int J Cancer. [Epub ahead of print].
By:
  • Bauer AS
  • Nazarov PV
  • Giese NA
  • Beghelli S
  • Heller A
  • Greenhalf W
  • Costello E
  • Muller A
  • Bier M
  • Strobel O
  • Hackert T
  • Vallar L
  • Scarpa A
  • Buchler MW
  • Neoptolemos JP
  • Kreis S
  • Hoheisel JD.

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

  • NORLUX-Glioma Biology
  • Animal Facility
  • Bioinformatics and Modelling
  • Genomics Center
  • Tumor Microenvironment
September 05, 2017
2017 Sep. Br J Cancer.117(6):813-825. Epub 2017 Aug 10.
By:
  • Abdul Rahim SA
  • Dirkse A
  • Oudin A
  • Schuster A
  • Bohler J
  • Barthelemy V
  • Muller A
  • Vallar L
  • Janji B
  • Golebiewska A
  • Niclou SP.

Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

  • Luxembourg Center of Neuropathology
  • Bioinformatics and Modelling
  • Genomics Center
  • NORLUX-Glioma Biology
August 01, 2017
2017 Aug. Int J Oncol.51(2):702-714. Epub 2017 Jun 21.
By:
  • Armento A
  • Ilina EI
  • Kaoma T
  • Muller A
  • Vallar L
  • Niclou SP
  • Kruger MA
  • Mittelbronn M
  • Naumann U.

Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia.

  • Bioinformatics and Modelling
  • Genomics Center
August 01, 2017
2017 Aug. J Pathol.242(4):421-434. Epub 2017 Jul 5.
By:
  • Gauchotte G
  • Hergalant S
  • Vigouroux C
  • Casse JM
  • Houlgatte R
  • Kaoma T
  • Helle D
  • Brochin L
  • Rech F
  • Peyre M
  • Labrousse F
  • Vallar L
  • Gueant JL
  • Vignaud JM
  • Battaglia-Hsu SF.

Chemotherapy resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism.

  • Bioinformatics and Modelling
  • Genomics Center
July 01, 2017
2017 Jul. Cancer Discov.7(7):716-735. Epub 2017 Apr 17.
By:
  • Farge T
  • Saland E
  • de Toni F
  • Aroua N
  • Hosseini M
  • Perry R
  • Bosc C
  • Sugita M
  • Stuani L
  • Fraisse M
  • Scotland S
  • Larrue C
  • Boutzen H
  • Feliu V
  • Nicolau-Travers ML
  • Cassant-Sourdy S
  • Broin N
  • David M
  • Serhan N
  • Sarry A
  • Tavitian S
  • Kaoma T
  • Vallar L
  • Iacovoni J
  • Linares LK
  • Montersino C
  • Castellano R
  • Griessinger E
  • Collette Y
  • Duchamp O
  • Barreira Y
  • Hirsch P
  • Palama T
  • Gales L
  • Delhommeau F
  • Garmy-Susini BH
  • Portais JC
  • Vergez F
  • Selak M
  • Danet-Desnoyers G
  • Carroll M
  • Recher C
  • Sarry JE.

RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples.

  • Bioinformatics and Modelling
  • Genomics Center
  • Discovery Proteomics
June 06, 2017
2017 Jun. BMC Genomics.18(1):443.
By:
  • Nazarov PV
  • Muller A
  • Kaoma T
  • Nicot N
  • Maximo C
  • Birembaut P
  • Tran NL
  • Dittmar G
  • Vallar L.

The angiogenic switch leads to a metabolic shift in human glioblastoma.

  • NORLUX-Glioma Biology
  • Bioinformatics and Modelling
  • Genomics Center
March 01, 2017
2017 Mar. Neuro Oncol.19(3):383-393.
By:
  • Talasila KM
  • Rosland GV
  • Hagland HR
  • Eskilsson E
  • Flones IH
  • Fritah S
  • Azuaje F
  • Atai N
  • Harter PN
  • Mittelbronn M
  • Andersen M
  • Joseph JV
  • Hossain JA
  • Vallar L
  • Noorden CJ
  • Niclou SP
  • Thorsen F
  • Tronstad KJ
  • Tzoulis C
  • Bjerkvig R
  • Miletic H.

Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines.

  • Genomics Center
March 01, 2017
2017 Mar. Biochim Biophys Acta-Mol Cell Res.1864(3):516-526. Epub 2016 Dec 9.
By:
  • Rolvering C
  • Zimmer AD
  • Kozar I
  • Hermanns HM
  • Letellier E
  • Vallar L
  • Nazarov PV
  • Nicot N
  • Ginolhac A
  • Haan S
  • Behrmann I
  • Haan C.

Preventive and chronic mineralocorticoid receptor antagonism is highly beneficial in obese SHHF rats.

  • Genomics Center
June 01, 2016
2016 Jun. Br J Pharmacol.173(11):1805-19. Epub 2016 Apr 26.
By:
  • Youcef G
  • Olivier A
  • Nicot N
  • Muller A
  • Deng C
  • Labat C
  • Fay R
  • Rodriguez-Gueant RM
  • Leroy C
  • Jaisser F
  • Zannad F
  • Lacolley P
  • Vallar L
  • Pizard A.

Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
  • Bioinformatics and Modelling
  • Genomics Center
  • National Cytometry Platform
May 31, 2016
2016 May. Oncotarget.7(22):31955-71.
By:
  • Bougnaud S
  • Golebiewska A
  • Oudin A
  • Keunen O
  • Harter PN
  • Mader L
  • Azuaje F
  • Fritah S
  • Stieber D
  • Kaoma T
  • Vallar L
  • Brons NH
  • Daubon T
  • Miletic H
  • Sundstrom T
  • Herold-Mende C
  • Mittelbronn M
  • Bjerkvig R
  • Niclou SP.

Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.

  • Bioinformatics and Modelling
  • Genomics Center
  • Clinical Proteomics
  • NORLUX-Glioma Biology
May 31, 2016
2016 May. Sci Rep.6:26822.
By:
  • Rodius S
  • Androsova G
  • Gotz L
  • Liechti R
  • Crespo I
  • Merz S
  • Nazarov PV
  • de Klein N
  • Jeanty C
  • Gonzalez-Rosa JM
  • Muller A
  • Bernardin F
  • Niclou SP
  • Vallar L
  • Mercader N
  • Ibberson M
  • Xenarios I
  • Azuaje F.

Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia.

  • Genomics Center
April 04, 2016
2016 Apr. J Exp Med.213(4):483-97. Epub 2016 Mar 7.
By:
  • Boutzen H
  • Saland E
  • Larrue C
  • de Toni F
  • Gales L
  • Castelli FA
  • Cathebas M
  • Zaghdoudi S
  • Stuani L
  • Kaoma T
  • Riscal R
  • Yang G
  • Hirsch P
  • David M
  • De Mas-Mansat V
  • Delabesse E
  • Vallar L
  • Delhommeau F
  • Jouanin I
  • Ouerfelli O
  • Le Cam L
  • Linares LK
  • Junot C
  • Portais JC
  • Vergez F
  • Recher C
  • Sarry JE.

L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway.

  • Genomics Center
March 01, 2016
2016 Mar. Faseb j.30(3):1218-33. Epub 2015 Nov 30.
By:
  • Lommel MJ
  • Trairatphisan P
  • Gabler K
  • Laurini C
  • Muller A
  • Kaoma T
  • Vallar L
  • Sauter T
  • Schaffner-Reckinger E.

Gene regulatory network inference of Immunoresponsive Gene 1 (IRG1) identifies Interferon Regulatory Factor 1 (IRF1) as its transcriptional regulator in mammalian macrophages.

  • NORLUX-Glioma Biology
  • Genomics Center
February 12, 2016
2016 Feb. PLoS One.11(2):e0149050.
By:
  • Tallam A
  • Perumal TM
  • Antony PM
  • Jager C
  • Fritz JV
  • Vallar L
  • Balling R
  • Del Sol A
  • Michelucci A.

Decoding of exon splicing patterns in the human RUNX1-RUNX1T1 fusion gene.

  • Genomics Center
November 01, 2015
2015 Nov. Int J Biochem Cell Biol.68:48-58. Epub 2015 Aug 29.
By:
  • Grinev VV
  • Migas AA
  • Kirsanava AD
  • Mishkova OA
  • Siomava N
  • Ramanouskaya TV
  • Vaitsiankova AV
  • Ilyushonak IM
  • Nazarov PV
  • Vallar L
  • Aleinikova OV.

Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network.

  • Genomics Center
October 19, 2015
2015 Oct. BMC Genomics.16:809.
By:
  • Pacheco MP
  • John E
  • Kaoma T
  • Heinaniemi M
  • Nicot N
  • Vallar L
  • Bueb JL
  • Sinkkonen L
  • Sauter T.

Whole transcriptome microarrays identify long non-coding RNAs associated with cardiac hypertrophy.

  • Cardiovascular Research Unit
  • Genomics Center
September 01, 2015
2015 Sep. Genom Data.5:68-71.
By:
  • Zhang L
  • Hamad EA
  • Vausort M
  • Funakoshi H
  • Nicot N
  • Nazarov PV
  • Vallar L
  • Feldman AM
  • Wagner DR
  • Devaux Y
  • Cardiolinc network.

The oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart.

  • Genomics Center
July 17, 2015
2015 Jul. Jakstat.4(1):e1062596.
By:
  • Haan S
  • Bahlawane C
  • Wang J
  • Nazarov PV
  • Muller A
  • Eulenfeld R
  • Haan C
  • Rolvering C
  • Vallar L
  • Satagopam VP
  • Sauter T
  • Wiesinger MY.

Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma.

  • NORLUX-Glioma Biology
  • Genomics Center
May 01, 2015
2015 May. PLoS One.10(5):e0123544.
By:
  • Sanzey M
  • Abdul Rahim SA
  • Oudin A
  • Dirkse A
  • Kaoma T
  • Vallar L
  • Herold-Mende C
  • Bjerkvig R
  • Golebiewska A
  • Niclou SP.

Constitutive activation of oncogenic PDGFRalpha-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRalpha signalling characteristics.

  • Genomics Center
March 31, 2015
2015 Mar. Cell Commun Signal.13:21.
By:
  • Bahlawane C
  • Eulenfeld R
  • Wiesinger MY
  • Wang J
  • Muller A
  • Girod A
  • Nazarov PV
  • Felsch K
  • Vallar L
  • Sauter T
  • Satagopam VP
  • Haan S.