Andy Chevigne

Latest publications

Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.

  • Immuno-Pharmacology and Interactomics
May 01, 2018
2018 May. Br J Pharmacol.175(9):1419-1438. Epub 2018 Mar 23.
By:
  • Szpakowska M
  • Nevins AM
  • Meyrath M
  • Rhainds D
  • D'Huys T
  • Guite-Vinet F
  • Dupuis N
  • Gauthier PA
  • Counson M
  • Kleist A
  • St-Onge G
  • Hanson J
  • Schols D
  • Volkman BF
  • Heveker N
  • Chevigne A.

Development of Mimokines, chemokine N terminus-based CXCR4 inhibitors optimized by phage display and rational design.

  • Immuno-Pharmacology and Interactomics
  • HIV Clinical and Translational Research
March 23, 2018
2018 Mar. J Leukoc Biol.(Development of Mimokines, chemokine N terminus-based CXCR4 inhibitor). [Epub ahead of print].
By:
  • Fievez V
  • Szpakowska M
  • Mosbah A
  • Arumugam K
  • Mathu J
  • Counson M
  • Beaupain N
  • Seguin-Devaux C
  • Deroo S
  • Baudy-Floc'h M
  • Chevigne A.

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

  • Immuno-Pharmacology and Interactomics
March 09, 2018
2018 Mar. Biochem Pharmacol. [Epub ahead of print].
By:
  • Szpakowska M
  • Meyrath M
  • Reynders N
  • Counson M
  • Hanson J
  • Steyaert J
  • Chevigne A.

Profiling the extended cleavage specificity of the house dust mite protease allergens Der p 1, Der p 3 and Der p 6 for the prediction of new cell surface protein substrates.

  • Immuno-Pharmacology and Interactomics
June 27, 2017
2017 Jun. Int J Mol Sci.18(7).
By:
  • Jacquet A
  • Campisi V
  • Szpakowska M
  • Dumez ME
  • Galleni M
  • Chevigne A.

Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes beta-arrestin 2 recruitment.

  • Immuno-Pharmacology and Interactomics
June 01, 2017
2017 Jun. Mol Pharmacol.91(6):595-608. Epub 2017 Mar 17.
By:
  • Dupuis N
  • Laschet C
  • Franssen D
  • Szpakowska M
  • Gilissen J
  • Geubelle P
  • Soni A
  • Parent AS
  • Pirotte B
  • Chevigne A
  • Twizere JC
  • Hanson J.

The Lys-Asp-Tyr triad within the mite allergen Der p 1 propeptide is a critical structural element for the pH-dependent initiation of the protease maturation.

  • Immuno-Pharmacology and Interactomics
May 20, 2017
2017 May. Int J Mol Sci.18(5).
By:
  • Chevigne A
  • Campizi V
  • Szpakowska M
  • Bourry D
  • Dumez ME
  • Martins JC
  • Matagne A
  • Galleni M
  • Jacquet A.

GPCRs in immunity: Atypical receptors and novel concepts.

  • Immuno-Pharmacology and Interactomics
August 15, 2016
2016 Aug. Biochem Pharmacol.114:1-2. Epub 2016 Jun 29.
By:
  • Hanson J
  • Chevigne A.

Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7.

  • Immuno-Pharmacology and Interactomics
August 15, 2016
2016 Aug. Biochem Pharmacol.114:14-21. Epub 2016 May 27.
By:
  • Szpakowska M
  • Dupuis N
  • Baragli A
  • Counson M
  • Hanson J
  • Piette J
  • Chevigne A.

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.

  • Immuno-Pharmacology and Interactomics
August 15, 2016
2016 Aug. Biochem Pharmacol.114:53-68. Epub 2016 Apr 19.
By:
  • Kleist AB
  • Getschman AE
  • Ziarek JJ
  • Nevins AM
  • Gauthier PA
  • Chevigne A
  • Szpakowska M
  • Volkman BF.

vCCL2/vMIP-II, the viral master KEYmokine.

  • Immuno-Pharmacology and Interactomics
June 01, 2016
2016 Jun. J Leukoc Biol.99(6):893-900. Epub 2015 Dec 23.
By:
  • Szpakowska M
  • Chevigne A.

Isolation of an HIV-1 neutralizing peptide mimicking the CXCR4 and CCR5 surface from the heavy-chain complementary determining region 3 repertoire of a viremic controller.

  • Immuno-Pharmacology and Interactomics
  • Immune Systems Biology
  • HIV Clinical and Translational Research
January 28, 2016
2016 Jan. AIDS.30(3):377-82.
By:
  • Chevigne A
  • Delhalle S
  • Counson M
  • Beaupain N
  • Rybicki A
  • Verschueren C
  • Staub T
  • Schmit JC
  • Seguin-Devaux C
  • Deroo S.

Development of recombinant stable house dust mite allergen Der p 3 molecules for component-resolved diagnosis and specific immunotherapy.

  • Allergy and Clinical Immunology
  • Immuno-Pharmacology and Interactomics
March 19, 2015
2015 Mar. Clin Exp Allergy.45(4):823-34.
By:
  • Bouaziz A
  • Walgraffe D
  • Bouillot C
  • Herman J
  • Foguenne J
  • Gothot A
  • Louis R
  • Hentges F
  • Jacquet A
  • Mailleux AC
  • Chevigne A
  • Galleni M
  • Adam E
  • Dumez ME.

Closing the ring: a fourth extracellular loop in chemokine receptors.

  • Immuno-Pharmacology and Interactomics
September 02, 2014
2014 Sep. Sci Signal.7(341):pe21.
By:
  • Szpakowska M
  • Perez Bercoff D
  • Chevigne A.

Neutralising properties of peptides derived from CXCR4 extracellular loops towards CXCL12 binding and HIV-1 infection.

  • Immuno-Pharmacology and Interactomics
May 01, 2014
2014 May. Biochim Biophys Acta-Mol Cell Res.1843(5):1031-41(5):1031-41. Epub 2014 Jan 27.
By:
  • Chevigne A
  • Fievez V
  • Szpakowska M
  • Fischer A
  • Counson M
  • Plesseria JM
  • Schmit JC
  • Deroo S.

Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet.

  • Immuno-Pharmacology and Interactomics
March 31, 2014
2014 Mar. Front Immunol.5:138.
By:
  • Dumez ME
  • Herman J
  • Campizi V
  • Galleni M
  • Jacquet A
  • Chevigne A.

Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus.

  • Immuno-Pharmacology and Interactomics
March 01, 2014
2014 Mar. Biochim Biophys Acta.1840(3):1117-24. Epub 2013 Nov 27.
By:
  • Herman J
  • Thelen N
  • Smargiasso N
  • Mailleux AC
  • Luxen A
  • Cloes M
  • De Pauw E
  • Chevigne A
  • Galleni M
  • Dumez ME.

Allosteric inhibition of VIM metallo-beta-lactamases by a camelid nanobody.

  • Immuno-Pharmacology and Interactomics
March 15, 2013
2013 Mar. Biochem J.450(3):477-86.
By:
  • Sohier JS
  • Laurent C
  • Chevigne A
  • Pardon E
  • Srinivasan V
  • Wernery U
  • Lassaux P
  • Steyaert J
  • Galleni M.

Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors.

  • Immuno-Pharmacology and Interactomics
November 15, 2012
2012 Nov. Biochem Pharmacol.84(10):1366-80. Epub 2012 Aug 21.
By:
  • Szpakowska M
  • Fievez V
  • Arumugan K
  • van Nuland N
  • Schmit JC
  • Chevigne A.

Phages and HIV-1: from display to interplay.

  • Immuno-Pharmacology and Interactomics
April 13, 2012
2012 Apr. Int J Mol Sci.13(4):4727-94. Epub 2012 Apr 13.
By:
  • Delhalle S
  • Schmit JC
  • Chevigne A.

Engineering and screening the N-terminus of chemokines for drug discovery.

  • Immuno-Pharmacology and Interactomics
November 15, 2011
2011 Nov. Biochem Pharmacol.82(10):1438-56. Epub 2011 Jul 30.
By:
  • Chevigne A
  • Fievez V
  • Schmit JC
  • Deroo S.