Latest publications

Atypical opioid receptors: unconventional biology and therapeutic opportunities.

  • Immuno-Pharmacology and Interactomics
October 05, 2021
2021 Oct. Pharmacol Ther.108014. Online ahead of print.
By:
  • Palmer CB
  • Meyrath M
  • Canals M
  • Kostenis E
  • Chevigne A
  • Szpakowska M.

Maraviroc prevents HCC development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model.

  • Immuno-Pharmacology and Interactomics
September 30, 2021
2021 Sep. Cancers.13(19):4935.
By:
  • Passman AM
  • Strauss RP
  • McSpadden SB
  • Finch-Edmondson M
  • Andrewartha N
  • Woo KH
  • Diepeveen LA
  • Zhao W
  • Fernandez-Irigoyen J
  • Santamaria E
  • Medina-Ruiz L
  • Szpakowska M
  • Chevigne A
  • Park H
  • Carlessi R
  • Tirnitz-Parker JEE
  • Blanco JR
  • London R
  • Callus BA
  • Elsegood CL
  • Baker MV
  • Martinez A
  • Yeoh GCT
  • Ochoa-Callejero L.

New insights into the atypical chemokine receptor network and functions. (Doctoral thesis)

  • Immuno-Pharmacology and Interactomics
July 14, 2021
2021 Jul. Liège: Université de Liège, 2021.
By:
  • Meyrath M.

The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7.

  • Immuno-Pharmacology and Interactomics
June 02, 2021
2021 Jun. Signal Transduct Target Ther.6(1):209.
By:
  • Szpakowska M
  • Decker AM
  • Meyrath M
  • Palmer CB
  • Blough BE
  • Namjoshi OA
  • Chevigne A.

Active components from Cassia abbreviata prevent HIV-1 entry by distinct mechanisms of action.

  • HIV Clinical and Translational Research
  • Immuno-Pharmacology and Interactomics
May 10, 2021
2021 May. Int J Mol Sci.22(9):5052.
By:
  • Zheng Y
  • Yang XW
  • Schols D
  • Mori M
  • Botta B
  • Chevigne A
  • Mulinge M
  • Steinmetz A
  • Schmit JC
  • Seguin-Devaux C.

Proadrenomedullin N-Terminal 20 Peptides (PAMPs) are agonists of the chemokine scavenger receptor ACKR3/CXCR7.

  • Immuno-Pharmacology and Interactomics
  • Allergy and Clinical Immunology
April 09, 2021
2021 Apr. ACS Pharmacol Transl Sci.4(2):813-823.
By:
  • Meyrath M
  • Palmer CB
  • Reynders N
  • Vanderplasschen A
  • Ollert M
  • Bouvier M
  • Szpakowska M
  • Chevigne A.

CXCL10 Is an Agonist of the CC Family Chemokine Scavenger Receptor ACKR2/D6.

  • Immuno-Pharmacology and Interactomics
  • Tumor Immunotherapy and Microenvironment
  • Allergy and Clinical Immunology
  • Personalized Therapy Discovery
March 02, 2021
2021 Mar. Cancers.13(5):1054.
By:
  • Chevigné A
  • Janji B
  • Meyrath M
  • Reynders N
  • D’Uonnolo G
  • Uchański T
  • Xiao M
  • Berchem G
  • Ollert M
  • Kwon Y-J
  • Noman MZ
  • Szpakowska M.

CXCR4-binding Positron Emission Tomography tracers link monocyte recruitment and endothelial injury in murine atherosclerosis.

  • Immuno-Pharmacology and Interactomics
February 01, 2021
2021 Feb. Arterioscler Thromb Vasc Biol.41(2):822-836. Epub 2020 Dec 17.
By:
  • Baba O
  • Huang LH
  • Elvington A
  • Szpakowska M
  • Sultan D
  • Heo GS
  • Zhang X
  • Luehmann H
  • Detering L
  • Chevigne A
  • Liu Y
  • Randolph GJ.

Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22.

  • Immuno-Pharmacology and Interactomics
February 01, 2021
2021 Feb. J Leukoc Biol.109(2):373-376. Epub 2020 Jun 1.
By:
  • Meyrath M
  • Reynders N
  • Uchanski T
  • Chevigne A
  • Szpakowska M.

CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems.

  • Immuno-Pharmacology and Interactomics
October 05, 2020
2020 Oct. Front Immunol.11:561404.
By:
  • Kouzeli A
  • Collins PJ
  • Metzemaekers M
  • Meyrath M
  • Szpakowska M
  • Artinger M
  • Struyf S
  • Proost P
  • Chevigne A
  • Legler DF
  • Eberl M
  • Moser B.

GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11.

  • Immuno-Pharmacology and Interactomics
September 21, 2020
2020 Sep. Nat Commun.11(1):4752.
By:
  • Abboud D
  • Daly AF
  • Dupuis N
  • Bahri MA
  • Inoue A
  • Chevigne A
  • Ectors F
  • Plenevaux A
  • Pirotte B
  • Beckers A
  • Hanson J.

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides.

  • Immuno-Pharmacology and Interactomics
  • Immune Endocrine and Epigenetics
  • Transversal Translational Medicine
  • Allergy and Clinical Immunology
June 19, 2020
2020 Jun. Nat Commun.11(1):3033.
By:
  • Meyrath M
  • Szpakowska M
  • Zeiner J
  • Massotte L
  • Merz MP
  • Benkel T
  • Simon K
  • Ohnmacht J
  • Turner JD
  • Kruger R
  • Seutin V
  • Ollert M
  • Kostenis E
  • Chevigne A.

Assessment of biased agonism among distinct synthetic cannabinoid receptor agonist scaffolds.

  • Immuno-Pharmacology and Interactomics
April 10, 2020
2020 Apr. ACS Pharmacol Transl Sci.3(2):285-295.
By:
  • Wouters E
  • Walraed J
  • Robertson MJ
  • Meyrath M
  • Szpakowska M
  • Chevigne A
  • Skiniotis G
  • Stove C.

Structural features of an extended C-terminal tail modulate function of the chemokine CCL21.

  • Immuno-Pharmacology and Interactomics
April 07, 2020
2020 Apr. Biochemistry.59(13):1338-1350. Epub 2020 Mar 26.
By:
  • Moussouras NA
  • Hjorto GM
  • Peterson FC
  • Szpakowska M
  • Chevigne A
  • Rosenkilde MM
  • Volkman BF
  • Dwinell MB.

The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical relevance and therapy.

  • Immuno-Pharmacology and Interactomics
February 14, 2020
2020 Feb. Adv Cancer Res.145:99-138. Epub 2020 Feb 14.
By:
  • Sjoberg E
  • Meyrath M
  • Chevigne A
  • Ostman A
  • Augsten M
  • Szpakowska M.

The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein-protein interaction in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Immuno-Pharmacology and Interactomics
September 06, 2019
2019 Sep. Neurooncol Adv.1(1):vdz024.
By:
  • Neirinckx V
  • Hau AC
  • Schuster A
  • Fritah S
  • Tiemann K
  • Klein E
  • Nazarov PV
  • Matagne A
  • Szpakowska M
  • Meyrath M
  • Chevigne A
  • Schmidt MHH
  • Niclou SP.

Predominance of the heterozygous CCR5 delta-24 deletion in African individuals resistant to HIV infection might be related to a defect in CCR5 addressing at the cell surface.

  • HIV Clinical and Translational Research
  • Platform National Cytometry
  • Immuno-Pharmacology and Interactomics
September 01, 2019
2019 Sep. J Int AIDS Soc.22(9):e25384.
By:
  • Arendt V
  • Amand M
  • Iserentant G
  • Lemaire M
  • Masquelier C
  • Ndayisaba GF
  • Verhofstede C
  • Karita E
  • Allen S
  • Chevigne A
  • Schmit JC
  • Bercoff DP
  • Seguin-Devaux C.

FHR4-based immunoconjugates direct complement-dependent cytotoxicity and phagocytosis towards HER2-positive cancer cells.

  • HIV Clinical and Translational Research
  • Immuno-Pharmacology and Interactomics
  • Platform National Cytometry
July 31, 2019
2019 Jul. Mol Oncol.13(12):2531-2553. Epub 2019 Sep 30.
By:
  • Seguin-Devaux C
  • Plesseria JM
  • Verschueren C
  • Masquelier C
  • Iserentant G
  • Fullana M
  • Jozsi M
  • Cohen JHM
  • Dervillez X.

The distinct roles of CXCR3 variants and their ligands in the tumor microenvironment.

  • Immuno-Pharmacology and Interactomics
  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
June 18, 2019
2019 Jun. Cells.8(6).
By:
  • Reynders N
  • Abboud D
  • Baragli A
  • Noman MZ
  • Rogister B
  • Niclou SP
  • Heveker N
  • Janji B
  • Hanson J
  • Szpakowska M
  • Chevigne A.

A novel ACKR2-dependent role of fibroblast-derived CXCL14 in epithelial-to-mesenchymal transition and metastasis of breast cancer.

  • Immuno-Pharmacology and Interactomics
June 15, 2019
2019 Jun. Clin Cancer Res.25(12):3702-3717. Epub 2019 Mar 8.
By:
  • Sjoberg E
  • Meyrath M
  • Milde L
  • Herrera M
  • Lovrot J
  • Hagerstrand D
  • Frings O
  • Bartish M
  • Rolny C
  • Sonnhammer E
  • Chevigne A
  • Augsten M
  • Ostman A.