Latest publications

(Thia)calixarenephosphonic acids as potent inhibitors of the nucleic acid chaperone activity of the HIV-1 nucleocapsid protein with a new binding mode and multi-target antiviral activity.

  • HIV Clinical and Translational Research
February 11, 2020
2020 Feb. ACS Infect Dis. [Epub ahead of print].
By:
  • Humbert N
  • Kovalenko L
  • Saladini F
  • Giannini A
  • Pires M
  • Botzanowski T
  • Cherenok S
  • Boudier C
  • Sharma KK
  • Real E
  • Zaporozhets OA
  • Cianferani S
  • Seguin-Devaux C
  • Poggialini F
  • Botta M
  • Zazzi M
  • Kalchenko VI
  • Mori M
  • Mely Y.

A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds.

  • HIV Clinical and Translational Research
January 27, 2020
2020 Jan. ACS Medicinal Chemistry Letters. In Press.
By:
  • Ciaco S
  • Humbert N
  • Real E
  • Boudier C
  • Francesconi O
  • Roelens S
  • Nativi C
  • Seguin-Devaux C
  • Mori M
  • Mély Y.

Less cytotoxic protoflavones as antiviral agents: Protoapigenone 1′-O-isopropyl Ether shows improved selectivity against the Epstein-Barr Virus lytic cycle.

  • HIV Clinical and Translational Research
December 04, 2019
2019 Dec. Int J Mol Sci.20(24):6269.
By:
  • Vagvolgyi M
  • Girst G
  • Kusz N
  • Otvos SB
  • Fulop F
  • Hohmann J
  • Servais JY
  • Seguin-Devaux C
  • Chang FR
  • Chen MS
  • Chang LK
  • Hunyadi A.

Combattre l’hépatite C chez les usagers de drogues injectables au Luxembourg : illustration d’une approche intersectorielle.

  • HIV Clinical and Translational Research
December 01, 2019
2019 Dec. Addiction(s) : recherches et pratiques.(4):22-25.
By:
  • Berndt N
  • Devaux C
  • Seixas R.

Ensuring on-site Ebola patient monitoring and follow-up: Development of a laboratory structure embedded in an Ebola treatment center.

  • HIV Clinical and Translational Research
December 01, 2019
2019 Dec. Disaster Med Public Health Prep.13(5-6):1028-1034.
By:
  • Williams A
  • Amand M
  • Van den Bergh R
  • De Clerck H
  • Antierens A
  • Chaillet P.

Predominance of the heterozygous CCR5 delta-24 deletion in African individuals resistant to HIV infection might be related to a defect in CCR5 addressing at the cell surface.

  • HIV Clinical and Translational Research
  • Platform National Cytometry Platform
  • Immuno-Pharmacology and Interactomics
September 01, 2019
2019 Sep. J Int AIDS Soc.22(9):e25384.
By:
  • Arendt V
  • Amand M
  • Iserentant G
  • Lemaire M
  • Masquelier C
  • Ndayisaba GF
  • Verhofstede C
  • Karita E
  • Allen S
  • Chevigne A
  • Schmit JC
  • Bercoff DP
  • Seguin-Devaux C.

FHR4-based immunoconjugates direct complement-dependent cytotoxicity and phagocytosis towards HER2-positive cancer cells.

  • HIV Clinical and Translational Research
  • Immuno-Pharmacology and Interactomics
  • Platform National Cytometry Platform
July 31, 2019
2019 Jul. Mol Oncol.13(12):2531-2553. Epub 2019 Sep 30.
By:
  • Seguin-Devaux C
  • Plesseria JM
  • Verschueren C
  • Masquelier C
  • Iserentant G
  • Fullana M
  • Jozsi M
  • Cohen JHM
  • Dervillez X.

EMCDDA Case study 5 — Expanding HCV screening and hepatitis treatment and care for PWID to harm reduction centres. In Hepatitis C: new models of care for drugs services. (Book Chapter)

  • HIV Clinical and Translational Research
July 01, 2019
2019 Jul. EMCDDA, 2019. p.43-49. ISBN NA.
By:
  • Devaux C
  • Arendt V.

Drug-related infectious diseases: Update from the EMCDDA expert network. (Book)

  • HIV Clinical and Translational Research
June 01, 2019
2019 Jun. Luxembourg: Publications Office of the European Union, 2019. 20 p. ISBN 978-92-9497-434-1; 978-92-9497-431-0
By:
  • EMCDDA expert network (Devaux C. as collaborator for DRID network).

Injection of cocaine is associated with a recent HIV outbreak in people who inject drugs in Luxembourg.

  • HIV Clinical and Translational Research
  • Competence Center for Methodology and Statistics
  • Clinical and Epidemiological Investigation Center
May 16, 2019
2019 May. PLoS One.14(5):e0215570.
By:
  • Arendt V
  • Guillorit L
  • Origer A
  • Sauvageot N
  • Vaillant M
  • Fischer A
  • Goedertz H
  • Francois JH
  • Alexiev I
  • Staub T
  • Seguin-Devaux C.

Multicenter evaluation of the cobas® HIV-1 quantitative nucleic acid test for use on the cobas® 4800 system for the quantification of HIV-1 plasma viral load.

  • HIV Clinical and Translational Research
May 01, 2019
2019 May. J Clin Virol.114:43-49.
By:
  • Adams P
  • Vancutsem E
  • Nicolaizeau C
  • Servais JY
  • Pierard D
  • Francois JH
  • Schneider T
  • Paxinos EE
  • Marins EG
  • Canchola JA
  • Seguin-Devaux C.

Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 Sub-Subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium.

  • HIV Clinical and Translational Research
March 26, 2019
2019 Mar. Front Microbiol.10:613.
By:
  • Vinken L
  • Fransen K
  • Cuypers L
  • Alexiev I
  • Balotta C
  • Debaisieux L
  • Seguin-Devaux C
  • Garcia Ribas S
  • Gomes P
  • Incardona F
  • Kaiser R
  • Ruelle J
  • Sayan M
  • Paraschiv S
  • Paredes R
  • Peeters M
  • Sonnerborg A
  • Vancutsem E
  • Vandamme AM
  • Van den Wijngaert S
  • Van Ranst M
  • Verhofstede C
  • Stadler T
  • Lemey P
  • Van Laethem K.

In-vitro viral suppressive capacity correlates with immune checkpoint marker expression on peripheral CD8+ T cells in treated HIV-positive patients.

  • HIV Clinical and Translational Research
March 01, 2019
2019 Mar. Aids.33(3):387-398.
By:
  • Pannus P
  • Adams P
  • Willems E
  • Heyndrickx L
  • Florence E
  • Rutsaert S
  • De Spiegelaere W
  • Vandekerckhove L
  • Seguin-Devaux C
  • Vanham G.

HIV drug resistance. Clinical and public health implications. (Doctoral thesis)

  • HIV Clinical and Translational Research
February 28, 2019
2019 Feb. Utrechtht: University of Utrecht, 2019.
By:
  • Hofstra LM.

Malnutrition, Growth Response and Metabolic Changes Within the First 24 Months After ART Initiation in HIV-infected Children Treated Before the Age of 2 Years in West Africa.

  • HIV Clinical and Translational Research
August 01, 2018
2018 Aug. Pediatr Infect Dis J.37(8):781-787.
By:
  • Jesson J
  • Dahourou DL
  • Amorissani Folquet M
  • Malateste K
  • Yonaba C
  • N'Gbeche MS
  • Ouedraogo S
  • Mea-Assande V
  • Amani-Bosse C
  • Blanche S
  • Timite-Konan M
  • Leroy V
  • Monod Anrs 12206 Study Group (Arendt V DCaSJacftp.

Development of Mimokines, chemokine N terminus-based CXCR4 inhibitors optimized by phage display and rational design.

  • Immuno-Pharmacology and Interactomics
  • HIV Clinical and Translational Research
August 01, 2018
2018 Aug. J Leukoc Biol.104(2):343-357. Epub 2018 Mar 23.
By:
  • Fievez V
  • Szpakowska M
  • Mosbah A
  • Arumugam K
  • Mathu J
  • Counson M
  • Beaupain N
  • Seguin-Devaux C
  • Deroo S
  • Baudy-Floc'h M
  • Chevigne A.

The need for a European hepatitis C programme monitoring resistance to direct-acting antiviral agents in real life to eliminate hepatitis C.

  • HIV Clinical and Translational Research
July 01, 2018
2018 Jul. J Virus Erad.4(3):179-181.
By:
  • Popping S
  • Cento V
  • Garcia F
  • Ceccherini-Silberstein F
  • Seguin-Devaux C
  • Vijver DA
  • Boucher CA
  • on behalf of the HEPVIR working group of the European Society for translational Antiviral Research (ESAR).

Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.

  • HIV Clinical and Translational Research
June 01, 2018
2018 Jun. BMC Infect Dis.18(1):251.
By:
  • Colagrossi L
  • Hermans LE
  • Salpini R
  • Di Carlo D
  • Pas SD
  • Alvarez M
  • Ben-Ari Z
  • Boland G
  • Bruzzone B
  • Coppola N
  • Seguin-Devaux C
  • Dyda T
  • Garcia F
  • Kaiser R
  • Kose S
  • Krarup H
  • Lazarevic I
  • Lunar MM
  • Maylin S
  • Micheli V
  • Mor O
  • Paraschiv S
  • Paraskevis D
  • Poljak M
  • Puchhammer-Stockl E
  • Simon F
  • Stanojevic M
  • Stene-Johansen K
  • Tihic N
  • Trimoulet P
  • Verheyen J
  • Vince A
  • Lepej SZ
  • Weis N
  • Yalcinkaya T
  • Boucher CAB
  • Wensing AMJ
  • Perno CF
  • Svicher V
  • Hepvir working group of the European Society for translational antiviral research.

Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study.

  • HIV Clinical and Translational Research
June 01, 2018
2018 Jun. Lancet Gastroenterol Hepatol.3(6):383-403. Epub 2018 Mar 27.
By:
  • The Polaris Observatory Collaborators (Devaux C as collaborator for Luxembourg).

Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients.

  • HIV Clinical and Translational Research
May 09, 2018
2018 May. Sci Rep.8(1):7359.
By:
  • Belkhir L
  • Seguin-Devaux C
  • Elens L
  • Pauly C
  • Gengler N
  • Schneider S
  • Ruelle J
  • Haufroid V
  • Vandercam B.