Latest publications

Tumor Necrosis Factor-Mediated Survival of CD169(+) Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.

  • Experimental and Molecular Immunology
February 01, 2018
2018 Feb. J Virol.92(3).
By:
  • Shinde PV
  • Xu HC
  • Maney SK
  • Kloetgen A
  • Namineni S
  • Zhuang Y
  • Honke N
  • Shaabani N
  • Bellora N
  • Doerrenberg M
  • Trilling M
  • Pozdeev VI
  • van Rooijen N
  • Scheu S
  • Pfeffer K
  • Crocker PR
  • Tanaka M
  • Duggimpudi S
  • Knolle P
  • Heikenwalder M
  • Ruland J
  • Mak TW
  • Brenner D
  • Pandyra AA
  • Hoell JI
  • Borkhardt A
  • Haussinger D
  • Lang KS
  • Lang PA.
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Survival of the fittest: Cancer challenges T cell metabolism.

  • Experimental and Molecular Immunology
  • Immune Systems Biology
January 01, 2018
2018 Jan. Cancer Lett.412:216-223. Epub 2017 Oct 24.
By:
  • Franchina DG
  • He F
  • Brenner D.
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Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates.

  • Clinical and Applied Virology
  • Experimental and Molecular Immunology
November 10, 2017
2017 Nov. BMC Biotechnol.17(1):79.
By:
  • Kazaks A
  • Lu IN
  • Farinelle S
  • Ramirez A
  • Crescente V
  • Blaha B
  • Ogonah O
  • Mukhopadhyay T
  • de Obanos MP
  • Krimer A
  • Akopjana I
  • Bogans J
  • Ose V
  • Kirsteina A
  • Kazaka T
  • Stonehouse NJ
  • Rowlands DJ
  • Muller CP
  • Tars K
  • Rosenberg WM.
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MALT1 is an intrinsic regulator of regulatory T cells.

  • Experimental and Molecular Immunology
July 01, 2017
2017 Jul. Cell Death Differ.24(7):1214-1223. Epub 2015 Sep 25.
By:
  • Brustle A
  • Brenner D
  • Knobbe-Thomsen CB
  • Cox M
  • Lang PA
  • Lang KS
  • Mak TW.
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Glutathione primes T cell metabolism for inflammation.

  • Experimental and Molecular Immunology
  • Allergy and Clinical Immunology
April 18, 2017
2017 Apr. Immunity.46(4):675-689.
By:
  • Mak TW
  • Grusdat M
  • Duncan GS
  • Dostert C
  • Nonnenmacher Y
  • Cox M
  • Binsfeld C
  • Hao Z
  • Brustle A
  • Itsumi M
  • Jager C
  • Chen Y
  • Pinkenburg O
  • Camara B
  • Ollert M
  • Bindslev-Jensen C
  • Vasiliou V
  • Gorrini C
  • Lang PA
  • Lohoff M
  • Harris IS
  • Hiller K
  • Brenner D.
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K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.

  • Experimental and Molecular Immunology
January 13, 2017
2017 Jan. Nat Commun.8:14003.
By:
  • Hao Z
  • Sheng Y
  • Duncan GS
  • Li WY
  • Dominguez C
  • Sylvester J
  • Su YW
  • Lin GH
  • Snow BE
  • Brenner D
  • You-Ten A
  • Haight J
  • Inoue S
  • Wakeham A
  • Elford A
  • Hamilton S
  • Liang Y
  • Zuniga-Pflucker JC
  • He HH
  • Ohashi PS
  • Mak TW.
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RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

  • Experimental and Molecular Immunology
September 08, 2016
2016 Sep. Cell Physiol Biochem.39(4):1271-80. Epub 2016 Sep 8.
By:
  • Maney SK
  • Xu HC
  • Huang J
  • Pandyra AA
  • Ehlting C
  • Aguilar-Valenzuela R
  • Pozdeev VI
  • McIlwain DR
  • Zimmermann A
  • Bode JG
  • Hengel H
  • Kirschning CJ
  • Kim IR
  • Hiscott J
  • Brenner D
  • Haussinger D
  • Ohashi PS
  • Mak TW
  • Lang KS
  • Lang PA.
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TNF and ROS crosstalk in inflammation.

  • Experimental and Molecular Immunology
April 01, 2016
2016 Apr. Trends Cell Biol.26(4):249-61. Epub 2016 Jan 12.
By:
  • Blaser H
  • Dostert C
  • Mak TW
  • Brenner D.
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Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

  • Experimental and Molecular Immunology
November 01, 2015
2015 Nov. Cell Death Differ.22(11):1837-45. Epub 2015 Apr 17.
By:
  • Itsumi M
  • Inoue S
  • Elia AJ
  • Murakami K
  • Sasaki M
  • Lind EF
  • Brenner D
  • Harris IS
  • Chio
  • II
  • Afzal S
  • Cairns RA
  • Cescon DW
  • Elford AR
  • Ye J
  • Lang PA
  • Li WY
  • Wakeham A
  • Duncan GS
  • Haight J
  • You-Ten A
  • Snow B
  • Yamamoto K
  • Ohashi PS
  • Mak TW.
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Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1.

  • Experimental and Molecular Immunology
October 13, 2015
2015 Oct. Nat Commun.6:8576.
By:
  • Bothur E
  • Raifer H
  • Haftmann C
  • Stittrich AB
  • Brustle A
  • Brenner D
  • Bollig N
  • Bieringer M
  • Kang CH
  • Reinhard K
  • Camara B
  • Huber M
  • Visekruna A
  • Steinhoff U
  • Repenning A
  • Bauer UM
  • Sexl V
  • Radbruch A
  • Sparwasser T
  • Mashreghi MF
  • Wah Mak T
  • Lohoff M.
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Regulation of tumour necrosis factor signalling: live or let die.

  • Experimental and Molecular Immunology
May 26, 2015
2015 May. Nat Rev Immunol.15(6):362-74.
By:
  • Brenner D
  • Blaser H
  • Mak TW.
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Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.

  • Experimental and Molecular Immunology
April 15, 2015
2015 Apr. J Immunol.194(8):3723-34. Epub 2015 Mar 11.
By:
  • Bornancin F
  • Renner F
  • Touil R
  • Sic H
  • Kolb Y
  • Touil-Allaoui I
  • Rush JS
  • Smith PA
  • Bigaud M
  • Junker-Walker U
  • Burkhart C
  • Dawson J
  • Niwa S
  • Katopodis A
  • Nuesslein-Hildesheim B
  • Weckbecker G
  • Zenke G
  • Kinzel B
  • Traggiai E
  • Brenner D
  • Brustle A
  • St Paul M
  • Zamurovic N
  • McCoy KD
  • Rolink A
  • Regnier CH
  • Mak TW
  • Ohashi PS
  • Patel DD
  • Calzascia T.
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Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

  • Experimental and Molecular Immunology
February 09, 2015
2015 Feb. Cancer Cell.27(2):211-22. Epub 2015 Jan 22.
By:
  • Harris IS
  • Treloar AE
  • Inoue S
  • Sasaki M
  • Gorrini C
  • Lee KC
  • Yung KY
  • Brenner D
  • Knobbe-Thomsen CB
  • Cox MA
  • Elia A
  • Berger T
  • Cescon DW
  • Adeoye A
  • Brustle A
  • Molyneux SD
  • Mason JM
  • Li WY
  • Yamamoto K
  • Wakeham A
  • Berman HK
  • Khokha R
  • Done SJ
  • Kavanagh TJ
  • Lam CW
  • Mak TW.
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Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis.

  • Experimental and Molecular Immunology
January 27, 2015
2015 Jan. Proc Natl Acad Sci U S A.112(4):1119-24. Epub 2015 Jan 12.
By:
  • Afzal S
  • Hao Z
  • Itsumi M
  • Abouelkheer Y
  • Brenner D
  • Gao Y
  • Wakeham A
  • Hong C
  • Li WY
  • Sylvester J
  • Gilani SO
  • Brustle A
  • Haight J
  • You-Ten AJ
  • Lin GH
  • Inoue S
  • Mak TW.
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