Latest publications

Metabolic modulation of immunity: A new Concept in cancer immunotherapy.

  • Experimental and Molecular Immunology
July 07, 2020
2020 Jul. Cell Rep.32(1):107848.
By:
  • Guerra L
  • Bonetti L
  • Brenner D.

Glutathione restricts serine metabolism to preserve regulatory T cell function. (Doctoral thesis)

  • Experimental and Molecular Immunology
July 01, 2020
2020 Jul. University of Southern Denmark, 2020. 164 p.
By:
  • Kurniawan H.

Glutathione restricts serine metabolism to preserve Regulatory T cell function.

  • Experimental and Molecular Immunology
  • Allergy and Clinical Immunology
  • Immune Endocrine and Epigenetics
  • Cancer Metabolism Group
May 05, 2020
2020 May. Cell Metab.31(5):920-936 e7. Epub 2020 Mar 25.
By:
  • Kurniawan H
  • Franchina DG
  • Guerra L
  • Bonetti L
  • Baguet LS
  • Grusdat M
  • Schlicker L
  • Hunewald O
  • Dostert C
  • Merz MP
  • Binsfeld C
  • Duncan GS
  • Farinelle S
  • Nonnenmacher Y
  • Haight J
  • Das Gupta D
  • Ewen A
  • Taskesen R
  • Halder R
  • Chen Y
  • Jager C
  • Ollert M
  • Wilmes P
  • Vasiliou V
  • Harris IS
  • Knobbe-Thomsen CB
  • Turner JD
  • Mak TW
  • Lohoff M
  • Meiser J
  • Hiller K
  • Brenner D.

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

  • Experimental and Molecular Immunology
January 01, 2020
2020 Jan. Gut.69(1):133-145. Epub 2019 Aug 13.
By:
  • Zhuang Y
  • Xu HC
  • Shinde PV
  • Warfsmann J
  • Vasilevska J
  • Sundaram B
  • Behnke K
  • Huang J
  • Hoell JI
  • Borkhardt A
  • Pfeffer K
  • Taha MS
  • Herebian D
  • Mayatepek E
  • Brenner D
  • Ahmadian MR
  • Keitel V
  • Wieczorek D
  • Haussinger D
  • Pandyra AA
  • Lang KS
  • Lang PA.

IL-17(+) CD8(+) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.

  • Experimental and Molecular Immunology
December 16, 2019
2019 Dec. Nat Commun.10(1):5722.
By:
  • Luckel C
  • Picard F
  • Raifer H
  • Campos Carrascosa L
  • Guralnik A
  • Zhang Y
  • Klein M
  • Bittner S
  • Steffen F
  • Moos S
  • Marini F
  • Gloury R
  • Kurschus FC
  • Chao YY
  • Bertrams W
  • Sexl V
  • Schmeck B
  • Bonetti L
  • Grusdat M
  • Lohoff M
  • Zielinski CE
  • Zipp F
  • Kallies A
  • Brenner D
  • Berger M
  • Bopp T
  • Tackenberg B
  • Huber M.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

  • Experimental and Molecular Immunology
  • Quantitative Biology Unit
October 01, 2019
2019 Oct. Eur J Immunol.49(10):1457-1973.
By:
  • Cossarizza A
  • Chang HD
  • Radbruch A
  • Acs A
  • Adam D
  • Adam-Klages S
  • Agace WW
  • Aghaeepour N
  • Akdis M
  • Allez M
  • Almeida LN
  • Alvisi G
  • Anderson G
  • Andra I
  • Annunziato F
  • Anselmo A
  • Bacher P
  • Baldari CT
  • Bari S
  • Barnaba V
  • Barros-Martins J
  • Battistini L
  • Bauer W
  • Baumgart S
  • Baumgarth N
  • Baumjohann D
  • Baying B
  • Bebawy M
  • Becher B
  • Beisker W
  • Benes V
  • Beyaert R
  • Blanco A
  • Boardman DA
  • Bogdan C
  • Borger JG
  • Borsellino G
  • Boulais PE
  • Bradford JA
  • Brenner D
  • Brinkman RR
  • Brooks AES
  • Busch DH
  • Buscher M
  • Bushnell TP
  • Calzetti F
  • Cameron G
  • Cammarata I
  • Cao X
  • Cardell SL
  • Casola S
  • Cassatella MA
  • Cavani A
  • Celada A
  • Chatenoud L
  • Chattopadhyay PK
  • Chow S
  • Christakou E
  • Cicin-Sain L
  • Clerici M
  • Colombo FS
  • Cook L
  • Cooke A
  • Cooper AM
  • Corbett AJ
  • Cosma A
  • Cosmi L
  • Coulie PG
  • Cumano A
  • Cvetkovic L
  • Dang VD
  • Dang-Heine C
  • Davey MS
  • Davies D
  • De Biasi S
  • Del Zotto G
  • Dela Cruz GV
  • Delacher M
  • Della Bella S
  • Dellabona P
  • Deniz G
  • Dessing M
  • Di Santo JP
  • Diefenbach A
  • Dieli F
  • Dolf A
  • Dorner T
  • Dress RJ
  • Dudziak D
  • Dustin M
  • Dutertre CA
  • Ebner F
  • Eckle SBG
  • Edinger M
  • Eede P
  • Ehrhardt GRA
  • Eich M
  • Engel P
  • Engelhardt B
  • Erdei A
  • Esser C
  • Everts B
  • Evrard M
  • Falk CS
  • Fehniger TA
  • Felipo-Benavent M
  • Ferry H
  • Feuerer M
  • Filby A
  • Filkor K
  • Fillatreau S
  • Follo M
  • Forster I
  • Foster J
  • Foulds GA
  • Frehse B
  • Frenette PS
  • Frischbutter S
  • Fritzsche W
  • Galbraith DW
  • Gangaev A
  • Garbi N
  • Gaudilliere B
  • Gazzinelli RT
  • Geginat J
  • Gerner W
  • Gherardin NA
  • Ghoreschi K
  • Gibellini L
  • Ginhoux F
  • Goda K
  • Godfrey DI
  • Goettlinger C
  • Gonzalez-Navajas JM
  • Goodyear CS
  • Gori A
  • Grogan JL
  • Grummitt D
  • Grutzkau A
  • Haftmann C
  • Hahn J
  • Hammad H
  • Hammerling G
  • Hansmann L
  • Hansson G
  • Harpur CM
  • Hartmann S
  • Hauser A
  • Hauser AE
  • Haviland DL
  • Hedley D
  • Hernandez DC
  • Herrera G
  • Herrmann M
  • Hess C
  • Hofer T
  • Hoffmann P
  • Hogquist K
  • Holland T
  • Hollt T
  • Holmdahl R
  • Hombrink P
  • Houston JP
  • Hoyer BF
  • Huang B
  • Huang FP
  • Huber JE
  • Huehn J
  • Hundemer M
  • Hunter CA
  • Hwang WYK
  • Iannone A
  • Ingelfinger F
  • Ivison SM
  • Jack HM
  • Jani PK
  • Javega B
  • Jonjic S
  • Kaiser T
  • Kalina T
  • Kamradt T
  • Kaufmann SHE
  • Keller B
  • Ketelaars SLC
  • Khalilnezhad A
  • Khan S
  • Kisielow J
  • Klenerman P
  • Knopf J
  • Koay HF
  • Kobow K
  • Kolls JK
  • Kong WT
  • Kopf M
  • Korn T
  • Kriegsmann K
  • Kristyanto H
  • Kroneis T
  • Krueger A
  • Kuhne J
  • Kukat C
  • Kunkel D
  • Kunze-Schumacher H
  • Kurosaki T
  • Kurts C
  • Kvistborg P
  • Kwok I
  • Landry J
  • Lantz O
  • Lanuti P
  • LaRosa F
  • Lehuen A
  • LeibundGut-Landmann S
  • Leipold MD
  • Leung LYT
  • Levings MK
  • Lino AC
  • Liotta F
  • Litwin V
  • Liu Y
  • Ljunggren HG
  • Lohoff M
  • Lombardi G
  • Lopez L
  • Lopez-Botet M
  • Lovett-Racke AE
  • Lubberts E
  • Luche H
  • Ludewig B
  • Lugli E
  • Lunemann S
  • Maecker HT
  • Maggi L
  • Maguire O
  • Mair F
  • Mair KH
  • Mantovani A
  • Manz RA
  • Marshall AJ
  • Martinez-Romero A
  • Martrus G
  • Marventano I
  • Maslinski W
  • Matarese G
  • Mattioli AV
  • Maueroder C
  • Mazzoni A
  • McCluskey J
  • McGrath M
  • McGuire HM
  • McInnes IB
  • Mei HE
  • Melchers F
  • Melzer S
  • Mielenz D
  • Miller SD
  • Mills KHG
  • Minderman H
  • Mjosberg J
  • Moore J
  • Moran B
  • Moretta L
  • Mosmann TR
  • Muller S
  • Multhoff G
  • Munoz LE
  • Munz C
  • Nakayama T
  • Nasi M
  • Neumann K
  • Ng LG
  • Niedobitek A
  • Nourshargh S
  • Nunez G
  • O'Connor JE
  • Ochel A
  • Oja A
  • Ordonez D
  • Orfao A
  • Orlowski-Oliver E
  • Ouyang W
  • Oxenius A
  • Palankar R
  • Panse I
  • Pattanapanyasat K
  • Paulsen M
  • Pavlinic D
  • Penter L
  • Peterson P
  • Peth C
  • Petriz J
  • Piancone F
  • Pickl WF
  • Piconese S
  • Pinti M
  • Pockley AG
  • Podolska MJ
  • Poon Z
  • Pracht K
  • Prinz I
  • Pucillo CEM
  • Quataert SA
  • Quatrini L
  • Quinn KM
  • Radbruch H
  • Radstake T
  • Rahmig S
  • Rahn HP
  • Rajwa B
  • Ravichandran G
  • Raz Y
  • Rebhahn JA
  • Recktenwald D
  • Reimer D
  • Reis e Sousa C
  • Remmerswaal EBM
  • Richter L
  • Rico LG
  • Riddell A
  • Rieger AM
  • Robinson JP
  • Romagnani C
  • Rubartelli A
  • Ruland J
  • Saalmuller A
  • Saeys Y
  • Saito T
  • Sakaguchi S
  • Sala-de-Oyanguren F
  • Samstag Y
  • Sanderson S
  • Sandrock I
  • Santoni A
  • Sanz RB
  • Saresella M
  • Sautes-Fridman C
  • Sawitzki B
  • Schadt L
  • Scheffold A
  • Scherer HU
  • Schiemann M
  • Schildberg FA
  • Schimisky E
  • Schlitzer A
  • Schlosser J
  • Schmid S
  • Schmitt S
  • Schober K
  • Schraivogel D
  • Schuh W
  • Schuler T
  • Schulte R
  • Schulz AR
  • Schulz SR
  • Scotta C
  • Scott-Algara D
  • Sester DP
  • Shankey TV
  • Silva-Santos B
  • Simon AK
  • Sitnik KM
  • Sozzani S
  • Speiser DE
  • Spidlen J
  • Stahlberg A
  • Stall AM
  • Stanley N
  • Stark R
  • Stehle C
  • Steinmetz T
  • Stockinger H
  • Takahama Y
  • Takeda K
  • Tan L
  • Tarnok A
  • Tiegs G
  • Toldi G
  • Tornack J
  • Traggiai E
  • Trebak M
  • Tree TIM
  • Trotter J
  • Trowsdale J
  • Tsoumakidou M
  • Ulrich H
  • Urbanczyk S
  • van de Veen W
  • van den Broek M
  • van der Pol E
  • Van Gassen S
  • Van Isterdael G
  • van Lier RAW
  • Veldhoen M
  • Vento-Asturias S
  • Vieira P
  • Voehringer D
  • Volk HD
  • von Borstel A
  • von Volkmann K
  • Waisman A
  • Walker RV
  • Wallace PK
  • Wang SA
  • Wang XM
  • Ward MD
  • Ward-Hartstonge KA
  • Warnatz K
  • Warnes G
  • Warth S
  • Waskow C
  • Watson JV
  • Watzl C
  • Wegener L
  • Weisenburger T
  • Wiedemann A
  • Wienands J
  • Wilharm A
  • Wilkinson RJ
  • Willimsky G
  • Wing JB
  • Winkelmann R
  • Winkler TH
  • Wirz OF
  • Wong A
  • Wurst P
  • Yang JHM
  • Yang J
  • Yazdanbakhsh M
  • Yu L
  • Yue A
  • Zhang H
  • Zhao Y
  • Ziegler SM
  • Zielinski C
  • Zimmermann J
  • Zychlinsky A.

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery.

  • Experimental and Molecular Immunology
May 01, 2019
2019 May. Eur J Immunol.49(5):770-781. Epub 2019 Feb 20.
By:
  • Wilson AS
  • Law HD
  • Knobbe-Thomsen CB
  • Kearney CJ
  • Oliaro J
  • Binsfeld C
  • Burgio G
  • Starrs L
  • Brenner D
  • Randall KL
  • Brustle A.

Choline acetyltransferase-expressing T cells are required to control chronic viral infection.

  • Experimental and Molecular Immunology
February 08, 2019
2019 Feb. Science.363(6427):639-644.
By:
  • Cox MA
  • Duncan GS
  • Lin GHY
  • Steinberg BE
  • Yu LX
  • Brenner D
  • Buckler LN
  • Elia AJ
  • Wakeham AC
  • Nieman B
  • Dominguez-Brauer C
  • Elford AR
  • Gill KT
  • Kubli SP
  • Haight J
  • Berger T
  • Ohashi PS
  • Tracey KJ
  • Olofsson PS
  • Mak TW.

The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond.

  • Experimental and Molecular Immunology
January 01, 2019
2019 Jan. Physiol Rev.99(1):115-160.
By:
  • Dostert C
  • Grusdat M
  • Letellier E
  • Brenner D.

Structure and applications of novel influenza HA tri-stalk protein for evaluation of HA stem-specific immunity.

  • Clinical and Applied Virology
  • Experimental and Molecular Immunology
  • Eco-Immunology and Microbiome
September 27, 2018
2018 Sep. PLoS One.13(9):e0204776.
By:
  • Lu IN
  • Kirsteina A
  • Farinelle S
  • Willieme S
  • Tars K
  • Muller CP
  • Kazaks A.

Reactive Oxygen species: Involvement in T cell signaling and metabolism.

  • Experimental and Molecular Immunology
June 01, 2018
2018 Jun. Trends Immunol.39(6):489-502. Epub 2018 Feb 13.
By:
  • Franchina DG
  • Dostert C
  • Brenner D.

B-cell metabolic remodeling and cancer.

  • Experimental and Molecular Immunology
February 01, 2018
2018 Feb. Trends Cancer.4(2):138-150. Epub 2018 Feb 1.
By:
  • Franchina DG
  • Grusdat M
  • Brenner D.

Tumor Necrosis Factor-Mediated Survival of CD169(+) Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.

  • Experimental and Molecular Immunology
February 01, 2018
2018 Feb. J Virol.92(3).
By:
  • Shinde PV
  • Xu HC
  • Maney SK
  • Kloetgen A
  • Namineni S
  • Zhuang Y
  • Honke N
  • Shaabani N
  • Bellora N
  • Doerrenberg M
  • Trilling M
  • Pozdeev VI
  • van Rooijen N
  • Scheu S
  • Pfeffer K
  • Crocker PR
  • Tanaka M
  • Duggimpudi S
  • Knolle P
  • Heikenwalder M
  • Ruland J
  • Mak TW
  • Brenner D
  • Pandyra AA
  • Hoell JI
  • Borkhardt A
  • Haussinger D
  • Lang KS
  • Lang PA.

Survival of the fittest: Cancer challenges T cell metabolism.

  • Experimental and Molecular Immunology
  • Immune Systems Biology
January 01, 2018
2018 Jan. Cancer Lett.412:216-223. Epub 2017 Oct 24.
By:
  • Franchina DG
  • He F
  • Brenner D.

Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates.

  • Clinical and Applied Virology
  • Experimental and Molecular Immunology
November 10, 2017
2017 Nov. BMC Biotechnol.17(1):79.
By:
  • Kazaks A
  • Lu IN
  • Farinelle S
  • Ramirez A
  • Crescente V
  • Blaha B
  • Ogonah O
  • Mukhopadhyay T
  • de Obanos MP
  • Krimer A
  • Akopjana I
  • Bogans J
  • Ose V
  • Kirsteina A
  • Kazaka T
  • Stonehouse NJ
  • Rowlands DJ
  • Muller CP
  • Tars K
  • Rosenberg WM.

MALT1 is an intrinsic regulator of regulatory T cells.

  • Experimental and Molecular Immunology
July 01, 2017
2017 Jul. Cell Death Differ.24(7):1214-1223. Epub 2015 Sep 25.
By:
  • Brustle A
  • Brenner D
  • Knobbe-Thomsen CB
  • Cox M
  • Lang PA
  • Lang KS
  • Mak TW.

Glutathione primes T cell metabolism for inflammation.

  • Experimental and Molecular Immunology
  • Allergy and Clinical Immunology
April 18, 2017
2017 Apr. Immunity.46(4):675-689.
By:
  • Mak TW
  • Grusdat M
  • Duncan GS
  • Dostert C
  • Nonnenmacher Y
  • Cox M
  • Binsfeld C
  • Hao Z
  • Brustle A
  • Itsumi M
  • Jager C
  • Chen Y
  • Pinkenburg O
  • Camara B
  • Ollert M
  • Bindslev-Jensen C
  • Vasiliou V
  • Gorrini C
  • Lang PA
  • Lohoff M
  • Harris IS
  • Hiller K
  • Brenner D.

K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.

  • Experimental and Molecular Immunology
January 13, 2017
2017 Jan. Nat Commun.8:14003.
By:
  • Hao Z
  • Sheng Y
  • Duncan GS
  • Li WY
  • Dominguez C
  • Sylvester J
  • Su YW
  • Lin GH
  • Snow BE
  • Brenner D
  • You-Ten A
  • Haight J
  • Inoue S
  • Wakeham A
  • Elford A
  • Hamilton S
  • Liang Y
  • Zuniga-Pflucker JC
  • He HH
  • Ohashi PS
  • Mak TW.

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

  • Experimental and Molecular Immunology
September 08, 2016
2016 Sep. Cell Physiol Biochem.39(4):1271-80. Epub 2016 Sep 8.
By:
  • Maney SK
  • Xu HC
  • Huang J
  • Pandyra AA
  • Ehlting C
  • Aguilar-Valenzuela R
  • Pozdeev VI
  • McIlwain DR
  • Zimmermann A
  • Bode JG
  • Hengel H
  • Kirschning CJ
  • Kim IR
  • Hiscott J
  • Brenner D
  • Haussinger D
  • Ohashi PS
  • Mak TW
  • Lang KS
  • Lang PA.

TNF and ROS crosstalk in inflammation.

  • Experimental and Molecular Immunology
April 01, 2016
2016 Apr. Trends Cell Biol.26(4):249-61. Epub 2016 Jan 12.
By:
  • Blaser H
  • Dostert C
  • Mak TW
  • Brenner D.