Olivier Collignon

Latest publications

Innovation in oncology clinical trial design.

  • Competence Center for Methodology and Statistics
January 04, 2019
2019 Jan. Cancer Treat Rev. In press.
By:
  • Verweij J
  • Hendriks HR
  • Zwierzina H
  • on behalf of the Cancer Drug Development Forum (Collignon O as contributor).

Equivalence analyses of dissolution profiles with the Mahalanobis distance: a regulatory perspective and a comparison with a parametric maximum deviation-based approach.

  • Competence Center for Methodology and Statistics
December 05, 2018
2018 Dec. Biom J. [Epub ahead of print].
By:
  • Collignon O
  • Moellenhoff K
  • Dette H.

Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency.

  • Competence Center for Methodology and Statistics
November 20, 2018
2018 Nov. Trials.19(1):642.
By:
  • Collignon O
  • Koenig F
  • Koch A
  • Hemmings RJ
  • Petavy F
  • Saint-Raymond A
  • Papaluca-Amati M
  • Posch M.

Comparison of the modified unbounded penalty and the LASSO to select predictive genes of response to chemotherapy in breast cancer.

  • Competence Center for Methodology and Statistics
October 01, 2018
2018 Oct. PLoS One.13(10):e0204897.
By:
  • Collignon O
  • Han J
  • An H
  • Oh S
  • Lee Y.

Multi-arm, multi-drug trials from a reimbursement perspective. In Platform Trial Designs in Drug Development: Umbrella Trials and Basket Trials. (Book Chapter)

  • Competence Center for Methodology and Statistics
September 01, 2018
2018 Sep. Zoran Antonijevic Z and Beckman RA, eds. New York: Chapman and Hall/CRC 2018. p.119-124. (Chapman and Hall/CRC Biostatistics Series). ISBN 978-1138052451.
By:
  • Schiel A
  • Collignon O.

Regulatory assessment of drug dissolution profiles comparability via maximum deviation.

  • Competence Center for Methodology and Statistics
September 01, 2018
2018 Sep. Stat Med.37(20):2968-2981. Epub 2018 Jun 3.
By:
  • Moellenhoff K
  • Dette H
  • Kotzagiorgis E
  • Volgushev S
  • Collignon O.

Marketing authorisation applications submitted to the European Medicines Agency by small and medium-sized enterprises: an analysis of major objections and their impact on outcomes.

  • Competence Center for Methodology and Statistics
June 25, 2018
2018 Jun. Drug Discov Today.23(10):1801-1805. Epub 2018 Jun 25.
By:
  • Amaouche N
  • Casaert Salome H
  • Collignon O
  • Santos MR
  • Ziogas C.

Statistical considerations about the design and endpoints of randomized clinical trials for children with irritable bowel syndrome.

  • Competence Center for Methodology and Statistics
May 01, 2018
2018 May. Neurogastroenterol Motil.30(5):e13266.
By:
  • Collignon O
  • Petavy F.

Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 degrees C and 36 degrees C.

  • Cardiovascular Research Unit
  • Competence Center for Methodology and Statistics
June 20, 2017
2017 Jun. Crit Care.21(1):153.
By:
  • Stammet P
  • Dankiewicz J
  • Nielsen N
  • Fays F
  • Collignon O
  • Hassager C
  • Wanscher M
  • Unden J
  • Wetterslev J
  • Pellis T
  • Aneman A
  • Hovdenes J
  • Wise MP
  • Gilson G
  • Erlinge D
  • Horn J
  • Cronberg T
  • Kuiper M
  • Kjaergaard J
  • Gasche Y
  • Devaux Y
  • Friberg H
  • Target Temperature Management after Out-of-Hospital Cardiac Arrest (TTM) trial investigators.

Regulatory considerations on the enrollment of older adults in oncology clinical trials.

  • Competence Center for Methodology and Statistics
May 01, 2017
2017 May. J Geriatr Oncol.8(3):151-153. Epub 2017 Mar 9.
By:
  • Raimi-Abraham BT
  • de Orbe Izquierdo MS
  • Collignon O
  • Cerreta F.

Should baseline-dependent cut-offs really be used to define disease improvement in juvenile idiopathic arthritis? And few other considerations.

  • Competence Center for Methodology and Statistics
January 01, 2017
2017 Jan. Rheumatology.56(1):165-167. Epub 2016 Oct 22.
By:
  • Collignon O
  • Vesely R.

Statistical considerations in the development of clinical predictive scores: Comment on the article by Domsic et al.

  • Competence Center for Methodology and Statistics
January 01, 2017
2017 Jan. Arthritis Rheumatol.69(1):241-242.
By:
  • Collignon O
  • Vesely R.

Clustering of the values of a response variable and simultaneous covariate selection using a stepwise algorithm.

  • Competence Center for Methodology and Statistics
September 16, 2016
2016 Sep. Appl Math.7:1639-1648.
By:
  • Collignon O
  • Monnez JM.

Association of circulating microRNA-124-3p levels with outcomes after out-of-hospital cardiac arrest: A substudy of a randomized clinical trial.

  • Cardiovascular Research Unit
  • Competence Center for Methodology and Statistics
June 01, 2016
2016 Jun. JAMA Cardiol.1(3):305-13.
By:
  • Devaux Y
  • Dankiewicz J
  • Salgado-Somoza A
  • Stammet P
  • Collignon O
  • Gilje P
  • Gidlof O
  • Zhang L
  • Vausort M
  • Hassager C
  • Wise MP
  • Kuiper M
  • Friberg H
  • Cronberg T
  • Erlinge D
  • Nielsen N
  • for Target Temperature Management After Cardiac Arrest Trial Investigators.

Neuron-specific enolase as a predictor of death or poor neurological outcome after out-of-hospital cardiac arrest and targeted temperature management at 33°C and 36°C.

  • Cardiovascular Research Unit
  • Competence Center for Methodology and Statistics
May 19, 2015
2015 May. J Am Coll Cardiol.65(19):2104-14.
By:
  • Stammet P
  • Collignon O
  • Hassager C
  • Wise MP
  • Hovdenes J
  • Aneman A
  • Horn J
  • Devaux Y
  • Erlinge D
  • Kjaergaard J
  • Gasche Y
  • Wanscher M
  • Cronberg T
  • Friberg H
  • Wetterslev J
  • Pellis T
  • Kuiper M
  • Gilson G
  • Nielsen N
  • T. TM-Trial Investigators.

Bispectral index to predict neurological outcome early after cardiac arrest.

  • Cardiovascular Research Unit
  • Competence Center for Methodology and Statistics
December 01, 2014
2014 Dec. Resuscitation.85(12):1674-80. Epub 2014 Sep 23.
By:
  • Stammet P
  • Collignon O
  • Werer C
  • Sertznig C
  • Devaux Y.

Methodological issues in the design of a rheumatoid arthritis activity score and its cut-offs.

  • Competence Center for Methodology and Statistics
July 10, 2014
2014 Jul. Clin Epidemiol.6:221-226.
By:
  • Collignon O.

Door-to-balloon time and mortality.

  • Cardiovascular Research Unit
  • Competence Center for Methodology and Statistics
January 09, 2014
2014 Jan. N Engl J Med.370(2):180-1.
By:
  • Wagner DR
  • Devaux Y
  • Collignon O.

A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after acute myocardial infarction.

  • Cardiovascular Research Unit
  • Competence Center for Methodology and Statistics
August 13, 2013
2013 Aug. PLoS One.8(8):e70644.
By:
  • Devaux Y
  • Vausort M
  • McCann GP
  • Kelly D
  • Collignon O
  • Ng LL
  • Wagner DR
  • Squire IB.