Latest publications

Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity.

  • Proteomics of cellular signaling
  • Neuro-Oncology Laboratory
  • Computational Biomedicine
February 19, 2020
2020 Feb. Sci Rep.10(1):2896.
By:
  • Rodius S
  • de Klein N
  • Jeanty C
  • Sanchez-Iranzo H
  • Crespo I
  • Ibberson M
  • Xenarios I
  • Dittmar G
  • Mercader N
  • Niclou SP
  • Azuaje F.
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Standardization of the preanalytical phase of DNA extraction from fixed tissue for next-generation sequencing analyses.

  • Computational Biomedicine
January 25, 2020
2020 Jan. N Biotechnol.54:52-61. Epub 2019 Aug 6.
By:
  • Kofanova O
  • Bellora C
  • Garcia Frasquilho S
  • Antunes L
  • Hamot G
  • Mathay C
  • Mommaerts K
  • Muller A
  • DeWitt B
  • Betsou F.
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Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software.

  • Computational Biomedicine
  • Multiomics Data Science
January 13, 2020
2020 Jan. BMC Bioinformatics.21(1):16.
By:
  • Decamps C
  • Prive F
  • Bacher R
  • Jost D
  • Waguet A
  • Hadaca consortium (Kaoma T and Nazarov P as collaborators)
  • Houseman EA
  • Lurie E
  • Lutsik P
  • Milosavljevic A
  • Scherer M
  • Blum MGB
  • Richard M.
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A deep neural network approach to predicting clinical outcomes of neuroblastoma patients.

  • Computational Biomedicine
December 20, 2019
2019 Dec. BMC Med Genomics.12(Suppl 8):178.
By:
  • Tranchevent LC
  • Azuaje F
  • Rajapakse JC.
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Of gene expression and cell division time: A mathematical framework for advanced differential gene expression and data analysis.

  • Computational Biomedicine
December 18, 2019
2019 Dec. Cell Syst.9(6):569-579 e7. Epub 2019 Sep 11.
By:
  • Baum K
  • Schuchhardt J
  • Wolf J
  • Busse D.
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Deconvolution of transcriptomes and miRNomes by independent component analysis provides insights into biological processes and clinical outcomes of melanoma patients.

  • Multiomics Data Science
  • Computational Biomedicine
  • Proteomics of cellular signaling
September 18, 2019
2019 Sep. BMC Med Genomics.12(1):132.
By:
  • Nazarov PV
  • Wienecke-Baldacchino AK
  • Zinovyev A
  • Czerwinska U
  • Muller A
  • Nashan D
  • Dittmar G
  • Azuaje F
  • Kreis S.
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Analysis of correlation-based biomolecular networks from different omics data by fitting stochastic block models.

  • Computational Biomedicine
August 27, 2019
2019 Aug. F1000Res.8(465).
By:
  • Baum K
  • Rajapakse J
  • Azuaje F.
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Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia.

  • Computational Biomedicine
July 16, 2019
2019 Jul. Oncogenesis.8(8):39.
By:
  • Larrue C
  • Heydt Q
  • Saland E
  • Boutzen H
  • Kaoma T
  • Sarry JE
  • Joffre C
  • Recher C.
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Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

  • Luxembourg Center of Neuropathology
  • Neuro-Oncology Laboratory
  • Computational Biomedicine
July 01, 2019
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
By:
  • Zeiner PS
  • Preusse C
  • Golebiewska A
  • Zinke J
  • Iriondo A
  • Muller A
  • Kaoma T
  • Filipski K
  • Muller-Eschner M
  • Bernatz S
  • Blank AE
  • Baumgarten P
  • Ilina E
  • Grote A
  • Hansmann ML
  • Verhoff MA
  • Franz K
  • Feuerhake F
  • Steinbach JP
  • Wischhusen J
  • Stenzel W
  • Niclou SP
  • Harter PN
  • Mittelbronn M.
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Interplay between coding and exonic splicing regulatory sequences.

  • Computational Biomedicine
May 01, 2019
2019 May. Genome Res.29(5):711-722. Epub 2019 Apr 8.
By:
  • Fontrodona N
  • Aube F
  • Claude JB
  • Polveche H
  • Lemaire S
  • Tranchevent LC
  • Modolo L
  • Mortreux F
  • Bourgeois CF
  • Auboeuf D.
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Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.

  • Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Competence Center for Methodology and Statistics
  • Platform National Cytometry Platform
April 16, 2019
2019 Apr. Nat Commun.10(1):1787.
By:
  • Dirkse A
  • Golebiewska A
  • Buder T
  • Nazarov PV
  • Muller A
  • Poovathingal S
  • Brons NHC
  • Leite S
  • Sauvageot N
  • Sarkisjan D
  • Seyfrid M
  • Fritah S
  • Stieber D
  • Michelucci A
  • Hertel F
  • Herold-Mende C
  • Azuaje F
  • Skupin A
  • Bjerkvig R
  • Deutsch A
  • Voss-Bohme A
  • Niclou SP.
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Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis.

  • Neuro-Oncology Laboratory
  • Computational Biomedicine
April 10, 2019
2019 Apr. Acta Neuropathol Commun.7(1):55.
By:
  • Sundstrom T
  • Prestegarden L
  • Azuaje F
  • Aasen SN
  • Rosland GV
  • Varughese JK
  • Bahador M
  • Bernatz S
  • Braun Y
  • Harter PN
  • Skaftnesmo KO
  • Ingham ES
  • Mahakian LM
  • Tam S
  • Tepper CG
  • Petersen K
  • Ferrara KW
  • Tronstad KJ
  • Lund-Johansen M
  • Beschorner R
  • Bjerkvig R
  • Thorsen F.
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Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.

  • Computational Biomedicine
  • Neuro-Oncology Laboratory
April 08, 2019
2019 Apr. Neuro Oncol.21(7):890–900.
By:
  • Hossain JA
  • Latif MA
  • Ystaas LAR
  • Ninzima S
  • Riecken K
  • Muller A
  • Azuaje F
  • Joseph JV
  • Talasila KM
  • Ghimire J
  • Fehse B
  • Bjerkvig R
  • Miletic H.
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A DNA repair and cell-cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications.

  • DNA Repair and Chemoresistance
  • Computational Biomedicine
  • Neuro-Oncology Laboratory
March 15, 2019
2019 Mar. Cancer Res.79(6):1226-1238. Epub 2019 Jan 23.
By:
  • Gobin M
  • Nazarov PV
  • Warta R
  • Timmer M
  • Reifenberger G
  • Felsberg J
  • Vallar L
  • Chalmers AJ
  • Herold-Mende CC
  • Goldbrunner R
  • Niclou SP
  • Van Dyck E.
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Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

  • Computational Biomedicine
  • Neuro-Oncology Laboratory
  • Proteomics of cellular signaling
March 05, 2019
2019 Mar. F1000Res.7:1906.
By:
  • Azuaje F
  • Kaoma T
  • Jeanty C
  • Nazarov PV
  • Muller A
  • Kim SY
  • Dittmar G
  • Golebiewska A
  • Niclou SP.
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Artificial intelligence for precision oncology: beyond patient stratification.

  • Computational Biomedicine
February 25, 2019
2019 Feb. NPJ Precis Oncol.3:6.
By:
  • Azuaje F.
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RNAi/CRISPR Screens: from a Pool to a Valid Hit.

  • Neuro-Oncology Laboratory
  • Computational Biomedicine
  • DNA Repair and Chemoresistance
January 01, 2019
2019 Jan. Trends Biotechnol.37(1):38-55. Epub 2018 Aug 31.
By:
  • Schuster A
  • Erasimus H
  • Fritah S
  • Nazarov PV
  • van Dyck E
  • Niclou SP
  • Golebiewska A.
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Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.

  • Neuro-Oncology Laboratory
  • Computational Biomedicine
November 01, 2018
2018 Nov. EMBO Rep.19(11). Epub 2018 Sep 11.
By:
  • Sousa C
  • Golebiewska A
  • Poovathingal SK
  • Kaoma T
  • Pires-Afonso Y
  • Martina S
  • Coowar D
  • Azuaje F
  • Skupin A
  • Balling R
  • Biber K
  • Niclou SP
  • Michelucci A.
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Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.

  • Computational Biomedicine
November 01, 2018
2018 Nov. J Leukoc Biol.104(5):987-1002. Epub 2018 Aug 26.
By:
  • Kirchmeyer M
  • Servais FA
  • Hamdorf M
  • Nazarov PV
  • Ginolhac A
  • Halder R
  • Vallar L
  • Glanemann M
  • Rubie C
  • Lammert F
  • Kreis S
  • Behrmann I.
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Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer.

  • Proteomics of cellular signaling
  • Competence Center for Methodology and Statistics
  • Computational Biomedicine
  • Clinical and Epidemiological Investigation Center
August 06, 2018
2018 Aug. Br J Cancer.119(5):580-590. Epub 2018 Aug 6.
By:
  • El-Khoury V
  • Beland M
  • Schritz A
  • Kim SY
  • Nazarov PV
  • Gaboury L
  • Sertamo K
  • Bernardin F
  • Batutu R
  • Antunes L
  • Bennett CW
  • Fays F
  • Berchem G
  • Kim YJ.
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