Latest publications

A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease.

  • Quantitative Biology Unit
  • Computational Biomedicine
February 01, 2021
2021 Feb. Mol Neurobiol.58(2):576-602. Epub 2020 Sep 30.
By:
  • Hendrickx DM
  • Garcia P
  • Ashrafi A
  • Sciortino A
  • Schmit KJ
  • Kollmus H
  • Nicot N
  • Kaoma T
  • Vallar L
  • Buttini M
  • Glaab E.

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.

Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz.

  • Multiomics Data Science
  • Computational Biomedicine
October 01, 2020
2020 Oct. Nat Protoc.15(10):3240-3263. Epub 2020 Sep 25.
By:
  • Scherer M
  • Nazarov PV
  • Toth R
  • Sahay S
  • Kaoma T
  • Maurer V
  • Vedeneev N
  • Plass C
  • Lengauer T
  • Walter J
  • Lutsik P.

Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia.

  • Quantitative Biology Unit
  • Computational Biomedicine
October 01, 2020
2020 Oct. Cancer Discov.10(10):1544-1565. Epub 2020 Jul 8.
By:
  • Aroua N
  • Boet E
  • Ghisi M
  • Nicolau-Travers ML
  • Saland E
  • Gwilliam R
  • de Toni F
  • Hosseini M
  • Mouchel PL
  • Farge T
  • Bosc C
  • Stuani L
  • Sabatier M
  • Mazed F
  • Larrue C
  • Jarrou L
  • Gandarillas S
  • Bardotti M
  • Picard M
  • Syrykh C
  • Laurent C
  • Gotanegre M
  • Bonnefoy N
  • Bellvert F
  • Portais JC
  • Nicot N
  • Azuaje F
  • Kaoma T
  • Joffre C
  • Tamburini J
  • Recher C
  • Vergez F
  • Sarry JE.

Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
July 30, 2020
2020 Jul. F1000Res.7:1906.
By:
  • Azuaje F
  • Kaoma T
  • Jeanty C
  • Nazarov PV
  • Muller A
  • Kim SY
  • Dittmar G
  • Golebiewska A
  • Niclou SP.

A network-based embedding method for drug-target interaction prediction.

  • Computational Biomedicine
July 20, 2020
2020 Jul. Annu Int Conf IEEE Eng Med Biol Soc.2020:5304-5307.
By:
  • Parvizi P
  • Azuaje F
  • Theodoratou E
  • Luz S.

Deconvolution of “big data” in cancer genomics: from pancancer level to single cells. In Computer Technologies and Data Analysis (CTDA'2020) : Materials of II International Scientific-Practical Conference, Minsk, 23-24 April, 2020. (Book Chapter)

  • Multiomics Data Science
  • Computational Biomedicine
  • Quantitative Biology Unit
July 09, 2020
2020 Jul. Bishkek VA and Skakun V, eds. Minsk: BSU, 2020. p.7-11. ISBN 978-985-566-942-6.
By:
  • Chepeleva M
  • Wang Y
  • Kakoichankava A
  • Muller A
  • Kaoma T
  • Nazarov PV.

Machine learning-assisted neurotoxicity prediction in human midbrain organoids.

  • Computational Biomedicine
  • Transversal Translational Medicine
June 01, 2020
2020 Jun. Parkinsonism Relat Disord.75:105-109. Epub 2020 May 8.
By:
  • Monzel AS
  • Hemmer K
  • Kaoma T
  • Smits LM
  • Bolognin S
  • Lucarelli P
  • Rosety I
  • Zagare A
  • Antony P
  • Nickels SL
  • Krueger R
  • Azuaje F
  • Schwamborn JC.

Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity.

  • Proteomics of Cellular Signaling
  • Quantitative Biology Unit
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
February 19, 2020
2020 Feb. Sci Rep.10(1):2896.
By:
  • Rodius S
  • de Klein N
  • Jeanty C
  • Sanchez-Iranzo H
  • Crespo I
  • Ibberson M
  • Xenarios I
  • Dittmar G
  • Mercader N
  • Niclou SP
  • Azuaje F.

Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software.

  • Computational Biomedicine
  • Multiomics Data Science
January 13, 2020
2020 Jan. BMC Bioinformatics.21(1):16.
By:
  • Decamps C
  • Prive F
  • Bacher R
  • Jost D
  • Waguet A
  • Hadaca consortium (Kaoma T and Nazarov P as collaborators)
  • Houseman EA
  • Lurie E
  • Lutsik P
  • Milosavljevic A
  • Scherer M
  • Blum MGB
  • Richard M.

A deep neural network approach to predicting clinical outcomes of neuroblastoma patients.

  • Computational Biomedicine
December 20, 2019
2019 Dec. BMC Med Genomics.12(Suppl 8):178.
By:
  • Tranchevent LC
  • Azuaje F
  • Rajapakse JC.

Of gene expression and cell division time: A mathematical framework for advanced differential gene expression and data analysis.

  • Computational Biomedicine
December 18, 2019
2019 Dec. Cell Syst.9(6):569-579 e7. Epub 2019 Sep 11.
By:
  • Baum K
  • Schuchhardt J
  • Wolf J
  • Busse D.

Deconvolution of transcriptomes and miRNomes by independent component analysis provides insights into biological processes and clinical outcomes of melanoma patients.

  • Multiomics Data Science
  • Computational Biomedicine
  • Proteomics of Cellular Signaling
September 18, 2019
2019 Sep. BMC Med Genomics.12(1):132.
By:
  • Nazarov PV
  • Wienecke-Baldacchino AK
  • Zinovyev A
  • Czerwinska U
  • Muller A
  • Nashan D
  • Dittmar G
  • Azuaje F
  • Kreis S.

Analysis of correlation-based biomolecular networks from different omics data by fitting stochastic block models.

  • Computational Biomedicine
August 27, 2019
2019 Aug. F1000Res.8(465):465.
By:
  • Baum K
  • Rajapakse J
  • Azuaje F.

Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia.

  • Computational Biomedicine
July 16, 2019
2019 Jul. Oncogenesis.8(8):39.
By:
  • Larrue C
  • Heydt Q
  • Saland E
  • Boutzen H
  • Kaoma T
  • Sarry JE
  • Joffre C
  • Recher C.

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

  • Luxembourg Center of Neuropathology
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
July 01, 2019
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
By:
  • Zeiner PS
  • Preusse C
  • Golebiewska A
  • Zinke J
  • Iriondo A
  • Muller A
  • Kaoma T
  • Filipski K
  • Muller-Eschner M
  • Bernatz S
  • Blank AE
  • Baumgarten P
  • Ilina E
  • Grote A
  • Hansmann ML
  • Verhoff MA
  • Franz K
  • Feuerhake F
  • Steinbach JP
  • Wischhusen J
  • Stenzel W
  • Niclou SP
  • Harter PN
  • Mittelbronn M.

Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
July 01, 2019
2019 Jul. Neuro Oncol.21(7):890–900.
By:
  • Hossain JA
  • Latif MA
  • Ystaas LAR
  • Ninzima S
  • Riecken K
  • Muller A
  • Azuaje F
  • Joseph JV
  • Talasila KM
  • Ghimire J
  • Fehse B
  • Bjerkvig R
  • Miletic H.

Interplay between coding and exonic splicing regulatory sequences.

  • Computational Biomedicine
May 01, 2019
2019 May. Genome Res.29(5):711-722. Epub 2019 Apr 8.
By:
  • Fontrodona N
  • Aube F
  • Claude JB
  • Polveche H
  • Lemaire S
  • Tranchevent LC
  • Modolo L
  • Mortreux F
  • Bourgeois CF
  • Auboeuf D.

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Competence Center for Methodology and Statistics
  • Platform National Cytometry
April 16, 2019
2019 Apr. Nat Commun.10(1):1787.
By:
  • Dirkse A
  • Golebiewska A
  • Buder T
  • Nazarov PV
  • Muller A
  • Poovathingal S
  • Brons NHC
  • Leite S
  • Sauvageot N
  • Sarkisjan D
  • Seyfrid M
  • Fritah S
  • Stieber D
  • Michelucci A
  • Hertel F
  • Herold-Mende C
  • Azuaje F
  • Skupin A
  • Bjerkvig R
  • Deutsch A
  • Voss-Bohme A
  • Niclou SP.

Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
April 10, 2019
2019 Apr. Acta Neuropathol Commun.7(1):55.
By:
  • Sundstrom T
  • Prestegarden L
  • Azuaje F
  • Aasen SN
  • Rosland GV
  • Varughese JK
  • Bahador M
  • Bernatz S
  • Braun Y
  • Harter PN
  • Skaftnesmo KO
  • Ingham ES
  • Mahakian LM
  • Tam S
  • Tepper CG
  • Petersen K
  • Ferrara KW
  • Tronstad KJ
  • Lund-Johansen M
  • Beschorner R
  • Bjerkvig R
  • Thorsen F.