Simone Niclou

Latest publications

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts.

  • NORLUX Neuro-Oncology Laboratory
January 01, 2021
2021 Jan. Nat Genet.53(1):86-99. Epub 2021 Jan 7.
By:
  • Woo XY
  • Giordano J
  • Srivastava A
  • Zhao ZM
  • Lloyd MW
  • de Bruijn R
  • Suh YS
  • Patidar R
  • Chen L
  • Scherer S
  • Bailey MH
  • Yang CH
  • Cortes-Sanchez E
  • Xi Y
  • Wang J
  • Wickramasinghe J
  • Kossenkov AV
  • Rebecca VW
  • Sun H
  • Mashl RJ
  • Davies SR
  • Jeon R
  • Frech C
  • Randjelovic J
  • Rosains J
  • Galimi F
  • Bertotti A
  • Lafferty A
  • O'Farrell AC
  • Modave E
  • Lambrechts D
  • Ter Brugge P
  • Serra V
  • Marangoni E
  • El Botty R
  • Kim H
  • Kim JI
  • Yang HK
  • Lee C
  • Dean DA
  • 2nd
  • Davis-Dusenbery B
  • Evrard YA
  • Doroshow JH
  • Welm AL
  • Welm BE
  • Lewis MT
  • Fang B
  • Roth JA
  • Meric-Bernstam F
  • Herlyn M
  • Davies MA
  • Ding L
  • Li S
  • Govindan R
  • Isella C
  • Moscow JA
  • Trusolino L
  • Byrne AT
  • Jonkers J
  • Bult CJ
  • Medico E
  • Chuang JH
  • Pdxnet Consortium
  • EurOPDX Consortium (Golebiewska A. and Niclou S.P. as collaborators for Luxembourg).
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AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Quantitative Biology Unit
  • Proteomics of Cellular Signaling
December 11, 2020
2020 Dec. Nat Commun.11(1):6366.
By:
  • Schuster A
  • Klein E
  • Neirinckx V
  • Knudsen AM
  • Fabian C
  • Hau AC
  • Dieterle M
  • Oudin A
  • Nazarov PV
  • Golebiewska A
  • Muller A
  • Perez-Hernandez D
  • Rodius S
  • Dittmar G
  • Bjerkvig R
  • Herold-Mende C
  • Klink B
  • Kristensen BW
  • Niclou SP.
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Glioblastoma organoids: Pre-clinical applications and challenges in the context of immunotherapy.

  • NORLUX Neuro-Oncology Laboratory
December 08, 2020
2020 Dec. Front Oncol.10:604121.
By:
  • Klein E
  • Hau AC
  • Oudin A
  • Golebiewska A
  • Niclou SP.
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Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.
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New hints towards a precision medicine strategy for IDH wild-type glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
December 01, 2020
2020 Dec. Ann Oncol.31(12):1679-1692. Epub 2020 Sep 9.
By:
  • White K
  • Connor K
  • Clerkin J
  • Murphy BM
  • Salvucci M
  • O'Farrell AC
  • Rehm M
  • O'Brien D
  • Prehn JHM
  • Niclou SP
  • Lamfers MLM
  • Verreault M
  • Idbaih A
  • Verhaak R
  • Golebiewska A
  • Byrne AT.
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Temozolomide-induced RNA interactome uncovers novel lncRNA regulatory loops in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Quantitative Biology Unit
  • DNA Repair and Chemoresistance
September 10, 2020
2020 Sep. Cancers.12(9).
By:
  • Fritah S
  • Muller A
  • Jiang W
  • Mitra R
  • Sarmini M
  • Dieterle M
  • Golebiewska A
  • Ye T
  • Van Dyck E
  • Herold-Mende C
  • Zhao Z
  • Azuaje F
  • Niclou SP.
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Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
July 30, 2020
2020 Jul. F1000Res.7:1906.
By:
  • Azuaje F
  • Kaoma T
  • Jeanty C
  • Nazarov PV
  • Muller A
  • Kim SY
  • Dittmar G
  • Golebiewska A
  • Niclou SP.
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Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?

  • Translational Radiomics
  • NORLUX Neuro-Oncology Laboratory
July 01, 2020
2020 Jul. Neuro Oncol.22(7):903-904.
By:
  • Keunen O
  • Niclou SP.
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Dual blockade of STAT3 and EGFR: a key to unlock drug resistance in glioblastoma?

  • NORLUX Neuro-Oncology Laboratory
April 15, 2020
2020 Apr. Neuro Oncol.22(4):440-441.
By:
  • Fritah S
  • Niclou SP.
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Gender issues from the perspective of health-care professionals in Neuro-oncology: an EANO and EORTC Brain Tumor Group survey.

  • NORLUX Neuro-Oncology Laboratory
March 01, 2020
2020 Mar. Neurooncol Pract.7(2):249-259. Epub 2020 Jan 10.
By:
  • Le Rhun E
  • Weller M
  • Niclou SP
  • Short S
  • Piil K
  • Boele F
  • Rudà R
  • Theodorou M
  • Brandsma D
  • van den Bent M
  • Dirven L
  • on behalf of the EANO Women in Neuro-Oncology Committee.
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Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity.

  • Proteomics of Cellular Signaling
  • Quantitative Biology Unit
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
February 19, 2020
2020 Feb. Sci Rep.10(1):2896.
By:
  • Rodius S
  • de Klein N
  • Jeanty C
  • Sanchez-Iranzo H
  • Crespo I
  • Ibberson M
  • Xenarios I
  • Dittmar G
  • Mercader N
  • Niclou SP
  • Azuaje F.
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Revealing and harnessing tumour-associated microglia/macrophage heterogeneity in glioblastoma.

  • Neuro-Immunology Group
  • NORLUX Neuro-Oncology Laboratory
January 21, 2020
2020 Jan. Int J Mol Sci.21(3):E689.
By:
  • Pires-Afonso Y
  • Niclou SP
  • Michelucci A.
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Mutant IDH1 differently affects redox state and metabolism in glial cells of normal and tumor origin.

  • NORLUX Neuro-Oncology Laboratory
December 16, 2019
2019 Dec. Cancers.11(12):2028.
By:
  • Biedermann J
  • Preussler M
  • Conde M
  • Peitzsch M
  • Richter S
  • Wiedemuth R
  • Abou-El-Ardat K
  • Kruger A
  • Meinhardt M
  • Schackert G
  • Leenders WP
  • Herold-Mende C
  • Niclou SP
  • Bjerkvig R
  • Eisenhofer G
  • Temme A
  • Seifert M
  • Kunz-Schughart LA
  • Schrock E
  • Klink B.
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Longitudinal molecular trajectories of diffuse glioma in adults.

  • NORLUX Neuro-Oncology Laboratory
December 01, 2019
2019 Dec. Nature.576(7785):112-120. Epub 2019 Nov 20.
By:
  • Barthel FP
  • Johnson KC
  • Varn FS
  • Moskalik AD
  • Tanner G
  • Kocakavuk E
  • Anderson KJ
  • Abiola O
  • Aldape K
  • Alfaro KD
  • Alpar D
  • Amin SB
  • Ashley DM
  • Bandopadhayay P
  • Barnholtz-Sloan JS
  • Beroukhim R
  • Bock C
  • Brastianos PK
  • Brat DJ
  • Brodbelt AR
  • Bruns AF
  • Bulsara KR
  • Chakrabarty A
  • Chakravarti A
  • Chuang JH
  • Claus EB
  • Cochran EJ
  • Connelly J
  • Costello JF
  • Finocchiaro G
  • Fletcher MN
  • French PJ
  • Gan HK
  • Gilbert MR
  • Gould PV
  • Grimmer MR
  • Iavarone A
  • Ismail A
  • Jenkinson MD
  • Khasraw M
  • Kim H
  • Kouwenhoven MCM
  • LaViolette PS
  • Li M
  • Lichter P
  • Ligon KL
  • Lowman AK
  • Malta TM
  • Mazor T
  • McDonald KL
  • Molinaro AM
  • Nam DH
  • Nayyar N
  • Ng HK
  • Ngan CY
  • Niclou SP
  • Niers JM
  • Noushmehr H
  • Noorbakhsh J
  • Ormond DR
  • Park CK
  • Poisson LM
  • Rabadan R
  • Radlwimmer B
  • Rao G
  • Reifenberger G
  • Sa JK
  • Schuster M
  • Shaw BL
  • Short SC
  • Smitt PAS
  • Sloan AE
  • Smits M
  • Suzuki H
  • Tabatabai G
  • Van Meir EG
  • Watts C
  • Weller M
  • Wesseling P
  • Westerman BA
  • Widhalm G
  • Woehrer A
  • Yung WKA
  • Zadeh G
  • Huse JT
  • De Groot JF
  • Stead LF
  • Verhaak RGW
  • Glass Consortium.
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The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein-protein interaction in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Immuno-Pharmacology and Interactomics
September 06, 2019
2019 Sep. Neurooncol Adv.1(1):vdz024.
By:
  • Neirinckx V
  • Hau AC
  • Schuster A
  • Fritah S
  • Tiemann K
  • Klein E
  • Nazarov PV
  • Matagne A
  • Szpakowska M
  • Meyrath M
  • Chevigne A
  • Schmidt MHH
  • Niclou SP.
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Highlights of the inaugural ten - the launch of Neuro-Oncology Advances.

  • NORLUX Neuro-Oncology Laboratory
August 28, 2019
2019 Aug. Neurooncol Adv.1(1):vdz016.
By:
  • Nassiri F
  • Aldape K
  • Alhuwalia M
  • Brastianos P
  • Ducray F
  • Galldiks N
  • Kim A
  • Lamszus K
  • Mitchell D
  • Nabors LB
  • Nam DH
  • Natsume A
  • Ng HK
  • Niclou S
  • Sahm F
  • Short S
  • Walsh K
  • Wick W
  • Zadeh G.
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Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

  • Luxembourg Center of Neuropathology
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
July 01, 2019
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
By:
  • Zeiner PS
  • Preusse C
  • Golebiewska A
  • Zinke J
  • Iriondo A
  • Muller A
  • Kaoma T
  • Filipski K
  • Muller-Eschner M
  • Bernatz S
  • Blank AE
  • Baumgarten P
  • Ilina E
  • Grote A
  • Hansmann ML
  • Verhoff MA
  • Franz K
  • Feuerhake F
  • Steinbach JP
  • Wischhusen J
  • Stenzel W
  • Niclou SP
  • Harter PN
  • Mittelbronn M.
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The distinct roles of CXCR3 variants and their ligands in the tumor microenvironment.

  • Immuno-Pharmacology and Interactomics
  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
June 18, 2019
2019 Jun. Cells.8(6).
By:
  • Reynders N
  • Abboud D
  • Baragli A
  • Noman MZ
  • Rogister B
  • Niclou SP
  • Heveker N
  • Janji B
  • Hanson J
  • Szpakowska M
  • Chevigne A.
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Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Competence Center for Methodology and Statistics
  • Platform National Cytometry
April 16, 2019
2019 Apr. Nat Commun.10(1):1787.
By:
  • Dirkse A
  • Golebiewska A
  • Buder T
  • Nazarov PV
  • Muller A
  • Poovathingal S
  • Brons NHC
  • Leite S
  • Sauvageot N
  • Sarkisjan D
  • Seyfrid M
  • Fritah S
  • Stieber D
  • Michelucci A
  • Hertel F
  • Herold-Mende C
  • Azuaje F
  • Skupin A
  • Bjerkvig R
  • Deutsch A
  • Voss-Bohme A
  • Niclou SP.
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Irradiation to improve the response to immunotherapeutic agents in glioblastomas.

  • NORLUX Neuro-Oncology Laboratory
April 01, 2019
2019 Apr. Adv Radiat Oncol.4(2):268-282.
By:
  • Nesseler JP
  • Schaue D
  • McBride WH
  • Lee MH
  • Kaprealian T
  • Niclou SP
  • Nickers P.
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