Rejko Krüger

Latest publications

[The history of Freezing-of-gait in Parkinson's disease - from phenomena to symptom].

  • Transversal Translational Medicine
September 22, 2020
2020 Sep. Fortschr Neurol Psychiatr.88(9):573-581. Epub 2020 Sep 21.
By:
  • Klucken J
  • Winkler J
  • Kruger R
  • Jost W.
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The emerging role of RHOT1/Miro1 in the pathogenesis of Parkinson's disease.

  • Transversal Translational Medicine
September 15, 2020
2020 Sep. Front Neurol.11:587.
By:
  • Grossmann D
  • Berenguer-Escuder C
  • Chemla A
  • Arena G
  • Kruger R.
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Using high-content screening to generate single-cell gene-corrected patient-derived iPS clones reveals excess alpha-synuclein with familial Parkinson’s disease point mutation A30P.

  • Transversal Translational Medicine
September 10, 2020
2020 Sep. Cells.9(9):pii: cells9092065.
By:
  • Barbuti P
  • Antony P
  • Santos B
  • Massart F
  • Cruciani G
  • Dording C
  • Arias J
  • Schwamborn J
  • Kruger R.
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A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.

  • Transversal Translational Medicine
September 09, 2020
2020 Sep. Sci Transl Med.12(560).
By:
  • Boussaad I
  • Obermaier CD
  • Hanss Z
  • Bobbili DR
  • Bolognin S
  • Glaab E
  • Wolynska K
  • Weisschuh N
  • De Conti L
  • May C
  • Giesert F
  • Grossmann D
  • Lambert A
  • Kirchen S
  • Biryukov M
  • Burbulla LF
  • Massart F
  • Bohler J
  • Cruciani G
  • Schmid B
  • Kurz-Drexler A
  • May P
  • Duga S
  • Klein C
  • Schwamborn JC
  • Marcus K
  • Woitalla D
  • Vogt Weisenhorn DM
  • Wurst W
  • Baralle M
  • Krainc D
  • Gasser T
  • Wissinger B
  • Kruger R.
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[The role of inhibitors of COMT and MAO-B in the therapy of Parkinson's disease].

  • Transversal Translational Medicine
September 01, 2020
2020 Sep. Fortschr Neurol Psychiatr.88(9):620-633. Epub 2020 Jun 25.
By:
  • Woitalla D
  • Kruger R
  • Lorenzl S
  • Muller T
  • Oelwein G
  • Storch A
  • Wolz M
  • Wullner U.
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Excess of singleton loss-of-function variants in Parkinson's disease contributes to genetic risk.

  • Transversal Translational Medicine
September 01, 2020
2020 Sep. J Med Genet.57(9):617-623. Epub 2020 Feb 13.
By:
  • Bobbili DR
  • Banda P
  • Kruger R
  • May P.
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[Emerging concepts for precision medicine in Parkinson's disease with focus on genetics].

  • Transversal Translational Medicine
September 01, 2020
2020 Sep. Fortschr Neurol Psychiatr.88(9):558-566. Epub 2020 Jun 2.
By:
  • Stute L
  • Kruger R.
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Bidirectional relation between Parkinson's Disease and glioblastoma multiforme.

  • Transversal Translational Medicine
August 20, 2020
2020 Aug. Front Neurol.11:898.
By:
  • Mencke P
  • Hanss Z
  • Boussaad I
  • Sugier PE
  • Elbaz A
  • Kruger R.
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Unraveling molecular mechanisms of THAP1 missense mutations in DYT6 dystonia.

  • Transversal Translational Medicine
July 01, 2020
2020 Jul. J Mol Neurosci.70(7):999-1008. Epub 2020 Feb 28.
By:
  • Cheng F
  • Walter M
  • Wassouf Z
  • Hentrich T
  • Casadei N
  • Schulze-Hentrich J
  • Barbuti P
  • Krueger R
  • Riess O
  • Grundmann-Hauser K
  • Ott T.
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The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides.

  • Immuno-Pharmacology and Interactomics
  • Immune Endocrine and Epigenetics
  • Transversal Translational Medicine
  • Allergy and Clinical Immunology
June 19, 2020
2020 Jun. Nat Commun.11(1):3033.
By:
  • Meyrath M
  • Szpakowska M
  • Zeiner J
  • Massotte L
  • Merz MP
  • Benkel T
  • Simon K
  • Ohnmacht J
  • Turner JD
  • Kruger R
  • Seutin V
  • Ollert M
  • Kostenis E
  • Chevigne A.
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Genetic architecture of Parkinson's disease in the Indian population: harnessing genetic diversity to address critical gaps in Parkinson's disease research.

  • Transversal Translational Medicine
June 18, 2020
2020 Jun. Front Neurol.11:524.
By:
  • Rajan R
  • Divya KP
  • Kandadai RM
  • Yadav R
  • Satagopam VP
  • Madhusoodanan UK
  • Agarwal P
  • Kumar N
  • Ferreira T
  • Kumar H
  • Sreeram Prasad AV
  • Shetty K
  • Mehta S
  • Desai S
  • Kumar S
  • Prashanth LK
  • Bhatt M
  • Wadia P
  • Ramalingam S
  • Wali GM
  • Pandey S
  • Bartusch F
  • Hannussek M
  • Krüger J
  • Kumar-Sreelatha A
  • Grover S
  • Lichtner P
  • Sturm M
  • Roeper J
  • Busskamp V
  • Chandak GR
  • Schwamborn J
  • Seth P
  • Gasser T
  • Riess O
  • Goyal V
  • Pal PK
  • Borgohain R
  • Krüger R
  • Kishore A
  • Sharma M
  • Lux Giant Consortium.
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Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions.

  • Integrated BioBank of Luxembourg
  • Transversal Translational Medicine
  • Deep Digital Phenotyping Research Unit
  • PHR Custom Group 2
  • Clinical and Epidemiological Investigation Center
  • Competence Center for Methodology and Statistics
  • Luxembourg Center of Neuropathology
June 09, 2020
2020 Jun. BMC Biol.18(1):62.
By:
  • Baldini F
  • Hertel J
  • Sandt E
  • Thinnes CC
  • Neuberger-Castillo L
  • Pavelka L
  • Betsou F
  • Krüger R
  • Thiele I
  • NCER-PD Consortium (23 collaborators from LIH)
  • Aguayo G
  • Ammerlann W
  • Beaumont K
  • Esteves D
  • Ferrand JY
  • Gantenbein M
  • Geffers L
  • Graas J
  • Hanff AM
  • Hansen M
  • Huiart L
  • Larue C
  • Marques G
  • Menster M
  • Minelli M
  • Mittelbronn M
  • Mommaerts K
  • Nehrbass U
  • Perquin M
  • Schmitz S
  • Trezzi J
  • Vaillant M.
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Machine learning-assisted neurotoxicity prediction in human midbrain organoids.

  • Computational Biomedicine
  • Transversal Translational Medicine
June 01, 2020
2020 Jun. Parkinsonism Relat Disord.75:105-109. Epub 2020 May 8.
By:
  • Monzel AS
  • Hemmer K
  • Kaoma T
  • Smits LM
  • Bolognin S
  • Lucarelli P
  • Rosety I
  • Zagare A
  • Antony P
  • Nickels SL
  • Krueger R
  • Azuaje F
  • Schwamborn JC.
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Impaired mitochondrial-endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson's disease.

  • Transversal Translational Medicine
May 28, 2020
2020 May. Hum Mol Genet.29(8):1353-1364.
By:
  • Berenguer-Escuder C
  • Grossmann D
  • Antony P
  • Arena G
  • Wasner K
  • Massart F
  • Jarazo J
  • Walter J
  • Schwamborn JC
  • Grunewald A
  • Kruger R.
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Missing heritability in Parkinson's disease: the emerging role of non-coding genetic variation.

  • Transversal Translational Medicine
May 01, 2020
2020 May. J Neural Transm.127(5):729-748. Epub 2020 Apr 4.
By:
  • Ohnmacht J
  • May P
  • Sinkkonen L
  • Kruger R.
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Induced pluripotent stem cell line (LCSBi001-A) derived from a patient with Parkinson's disease carrying the p.D620N mutation in VPS35.

  • Transversal Translational Medicine
May 01, 2020
2020 May. Stem Cell Res.45:101776.
By:
  • Larsen SB
  • Hanss Z
  • Cruciani G
  • Massart F
  • Barbuti PA
  • Mellick G
  • Kruger R.
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Fibroblast mitochondria in idiopathic Parkinson's disease display morphological changes and enhanced resistance to depolarization.

  • Integrated BioBank of Luxembourg
  • Transversal Translational Medicine
January 31, 2020
2020 Jan. Sci Rep.10(1):1569.
By:
  • Antony PMA
  • Kondratyeva O
  • Mommaerts K
  • Ostaszewski M
  • Sokolowska K
  • Baumuratov AS
  • Longhino L
  • Poulain JF
  • Grossmann D
  • Balling R
  • Kruger R
  • Diederich NJ.
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Quality control strategy for CRISPR-Cas9-based gene editing complicated by a pseudogene.

  • Transversal Translational Medicine
January 08, 2020
2020 Jan. Front Genet.10:1297.
By:
  • Hanss Z
  • Boussaad I
  • Jarazo J
  • Schwamborn JC
  • Kruger R.
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Deep brain stimulation for freezing of gait in Parkinson's Disease with early motor complications.

  • Transversal Translational Medicine
January 01, 2020
2020 Jan. Mov Disord.35(1):82-90.
By:
  • Barbe MT
  • Tonder L
  • Krack P
  • Debu B
  • Schupbach M
  • Paschen S
  • Dembek TA
  • Kuhn AA
  • Fraix V
  • Brefel-Courbon C
  • Wojtecki L
  • Maltete D
  • Damier P
  • Sixel-Doring F
  • Weiss D
  • Pinsker M
  • Witjas T
  • Thobois S
  • Schade-Brittinger C
  • Rau J
  • Houeto JL
  • Hartmann A
  • Timmermann L
  • Schnitzler A
  • Stoker V
  • Vidailhet M
  • Deuschl G
  • EARLYSTIM study group (Krüger R. as member).
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Variants in Miro1 cause alterations of ER-Mitochondria contact sites in fibroblasts from Parkinson’s disease patients.

  • Transversal Translational Medicine
December 16, 2019
2019 Dec. J Clin Med.8(12):2226.
By:
  • Berenguer-Escuder C
  • Grossmann D
  • Massart F
  • Antony P
  • Burbulla LF
  • Glaab E
  • Imhoff S
  • Trinh J
  • Seibler P
  • Grunewald A
  • Kruger R.
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