Olivier Keunen
Latest publications
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
- Neuro-Immunology Group
- Computational Biomedicine
- Multiomics Data Science
- Luxembourg Center of Neuropathology
- Personalized Therapy Discovery
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?
- Translational Radiomics
- NORLUX Neuro-Oncology Laboratory
2020 Jul. Neuro Oncol.22(7):903-904.
Spatially regularized estimation of the tissue homogeneity model parameters in DCE-MRI using proximal minimization.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
2019 Dec. Magn Reson Med.82(6):2257-2272. Epub 2019 Jul 17.
Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier.
- Translational Radiomics
- NORLUX Neuro-Oncology Laboratory
2019 Nov. Mol Cancer Ther.18(11):2171-2181. Epub 2019 Aug 29.
Iterative methods for fast reconstruction of undersampled dynamic contrast-enhanced MRI data. In World Congress on Medical Physics and Biomedical Engineering 2018. (Book Chapter)
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
2019 Jan. Ibbott GS, Lhotska L, Sukupova L and Lackovic I, eds. Singapore: Springer Verlag, 2019. p.267-271. (IFMBE, Vol. 68, N°1). ISBN 978-981-10-9034-9 (print); 978-981-10-9035-6 (online).
Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
2018 Oct. J Cereb Blood Flow Metab.38(10):1741-1753. Epub 2017 Jun 19.
EGFL7 enhances surface expression of integrin alpha5beta1 to promote angiogenesis in malignant brain tumors.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
- Luxembourg Center of Neuropathology
2018 Sep. EMBO Mol Med.10(9).
Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
- Computational Biomedicine
2017 Dec. EMBO Mol Med.9(12):1681-1695.
Subtraction of subcutaneous fat to improve the prediction of visceral adiposity: exploring a new anthropometric track in overweight and obese youth.
- Public Health Research
- Translational Radiomics
- Competence Center for Methodology and Statistics
2017 Aug. Pediatr Diabetes.18(5):399-404. Epub 2016 Jul 12.
EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
2016 Dec. Neuro Oncol.18(12):1644-1655. Epub 2016 Jun 10.
Cardiometabolic risk: leg fat is protective during childhood.
- Public Health Research
- Translational Radiomics
- Competence Center for Methodology and Statistics
2016 Jun. Pediatr Diabetes.17(4):300-8. Epub 2015 Jun 17.
Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
- Computational Biomedicine
- Platform LUXGEN - Micro-Array
- Platform National Cytometry
2016 May. Oncotarget.7(22):31955-71.
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
2015 Dec. Nat Cell Biol.17(12):1556-68. Epub 2015 Nov 23.
Epigenetic activity of peroxisome proliferator-activated receptor gamma agonists increases the anticancer effect of histone deacetylase inhibitors on multiple myeloma cells.
- Tumor Immunotherapy and Microenvironment
- Translational Radiomics
- Laboratory of Oncolytic-Virus-Immuno-Therapeutics
2015 Jun. PLoS One.10(6):e0130339.
Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas.
- NORLUX Neuro-Oncology Laboratory
- Translational Radiomics
2015 Jan. Acta Neuropathol.129(1):115-31. Epub 2014 Oct 17.
Multimodal imaging of physiologic changes induced by anti-angiogenic therapy in glioblastoma. (Doctoral thesis)
- NORLUX Neuro-Oncology Laboratory
2014 Dec. Bergen: University of Bergen, 2014. 56 (+ References) p.
Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies.
- NORLUX Neuro-Oncology Laboratory
2014 Sep. Adv Drug Deliv Rev.76:98-115. Epub 2014 Jul 28.
Bevacizumab treatment for human glioblastoma. Can it induce cognitive impairment?
- NORLUX Neuro-Oncology Laboratory
2014 May. Neuro Oncol.16(5):754-6.
The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status.
- NORLUX Neuro-Oncology Laboratory
2013 Sep. Neuro Oncol.15(9):1200-11. Epub 2013 May 30.
EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis.
- NORLUX Neuro-Oncology Laboratory
2013 May. Acta Neuropathol.125(5):683-98. Epub 2013 Feb 22.