Guy Berchem
Latest publications
High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia.
- Tumor Stroma Interactions
- Tumor Immunotherapy and Microenvironment
2018 May. OncoImmunology.7(8):e1465167.
Inhibition of HIF1alpha-dependent upregulation of Phospho-l-Plastin resensitizes multiple myeloma cells to frontline therapy.
- Tumor Immunotherapy and Microenvironment
- Computational Biomedicine
- Laboratory of Oncolytic-Virus-Immuno-Therapeutics
2018 May. Int J Mol Sci.19(6):1551.
Targeting autophagy in the tumor microenvironment: New challenges and opportunities for regulating tumor immunity.
- Tumor Immunotherapy and Microenvironment
2018 Apr. Front Immunol.9:887.
Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target.
- Tumor Immunotherapy and Microenvironment
- Tumor Stroma Interactions
2018 Apr. OncoImmunology.7(8):e1452583.
Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.
- Tumor Stroma Interactions
- Platform National Cytometry
- Tumor Immunotherapy and Microenvironment
- NORLUX Neuro-Oncology Laboratory
- Allergy and Clinical Immunology
2018 Apr. Blood.131(14):1617-1621. Epub 2018 Feb 13.
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model.
- Tumor Stroma Interactions
2018 Apr. Haematologica.103(4):e154-e157. Epub 2018 Jan 5.
Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield.
- Tumor Immunotherapy and Microenvironment
2018 Mar. Autophagy.14(4):730-732. Epub 2018 Mar 11.
CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT.
- Tumor Immunotherapy and Microenvironment
- Computational Biomedicine
2018 Feb. OncoImmunology.7(4):e1345415.
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.
- Tumor Immunotherapy and Microenvironment
- Tumor Stroma Interactions
- Platform National Cytometry
2017 Oct. Proc Natl Acad Sci U S A.114(44):E9271-E9279. Epub 2017 Oct 16.
Activation of NK cells and disruption of PD-L1/PD-1 axis: two different ways for lenalidomide to block myeloma progression.
- Tumor Immunotherapy and Microenvironment
2017 Apr. Oncotarget.8(14):24031-24044.
The critical role of hypoxia in tumor-mediated immunosuppression. In Hypoxia and Human Diseases. (Book Chapter)
- Tumor Immunotherapy and Microenvironment
2017 Feb. Zheng J, ed. Intech, 2017. p.349-364. ISBN 978-953-51-2895-3.
Randomized phase II study of cabazitaxel versus methotrexate in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck previously treated with platinum-based therapy.
- Tumor Immunotherapy and Microenvironment
2016 Dec. Oncologist.21(12):1416-e17. Epub 2016 Nov 30.
Hijacker of the antitumor immune response: autophagy is showing its worst facet.
- Tumor Immunotherapy and Microenvironment
- Tumor Stroma Interactions
2016 Nov. Front Oncol.6(246):246.
Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer.
- Proteomics of Cellular Signaling
2016 Oct. Oncotarget.7(43):71013-71035.
miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function.
- Tumor Immunotherapy and Microenvironment
2016 Sep. Cancer Lett.380(1):257-62. Epub 2015 Oct 30.
A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells.
- Tumor Stroma Interactions
- Integrated BioBank of Luxembourg
- Laboratory of Oncolytic-Virus-Immuno-Therapeutics
2016 Jul. Br J Haematol.174(1):57-70. Epub 2016 Mar 11.
Chapter 12 - Regulation of autophagy in chronic lymphocytic leukemia: The role of Histone Deacetylase Inhibitors. In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. (Book Chapter)
- Proteomics of Cellular Signaling
2016 Apr. Academic Press, 2016. p.221–240. (Vol. 9). ISBN 978-0-12-802936-7.
The multifaceted role of autophagy in tumor evasion from immune surveillance.
- Tumor Immunotherapy and Microenvironment
- Tumor Stroma Interactions
2016 Apr. Oncotarget.7(14):17591-607.
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-beta and miR23a transfer.
- Tumor Immunotherapy and Microenvironment
- Tumor Stroma Interactions
2016 Apr. OncoImmunology.5(4):e1062968. Epub 2015 Jun 24.
Prospective evaluation of first-Line erlotinib in advanced Non-Small Cell Lung Cancer (NSCLC) carrying an activating EGFR mutation: A multicenter academic phase II study in Caucasian patients (FIELT).
- Tumor Immunotherapy and Microenvironment
2016 Mar. PLoS One.11(3):e0147599.