Bassam Janji
Latest publications
Selection of tumor-resistant variants following sustained natural killer cell-mediated immune stress.
- Tumor Immunotherapy and Microenvironment
2020 Nov. Oncol Rep.45(2):582-594. In Press.
Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34.
- Tumor Immunotherapy and Microenvironment
2020 Nov. Autophagy.(11):2110-2111. Epub 2020 Sep 5.
The 'Holy Grail' in immuno-oncology: AC BioScience SA is aiming to potentiate anti-PD-1 therapy efficacy through tumor cell conditioning strategy.
- Tumor Immunotherapy and Microenvironment
2020 Oct. Chimia.74(10):771-775.
Firing up the cold tumors by targeting Vps34.
- Tumor Immunotherapy and Microenvironment
2020 Aug. OncoImmunology.9(1):1809936.
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.
- Tumor Immunotherapy and Microenvironment
- Multiomics Data Science
- Integrated BioBank of Luxembourg
- Luxembourg Center of Neuropathology
2020 Aug. Autophagy.16(8):1436-1452. Epub 2019 Nov 27.
The emerging impact of autophagy on the antitumor immune response. In Autophagy in immune response: Impact on cancer immunotherapy. 1st ed. (Book Chapter)
- Tumor Immunotherapy and Microenvironment
2020 May. Chouaib S, ed. London: Academic Press, 2020. p.109-117. (Sensitizing Agent-Canc Resistant-Cell Mediated Immtherap, Vol.1). ISBN 978-0-12-819609-0.
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy.
- Tumor Immunotherapy and Microenvironment
2020 May. Sci Adv.6(18):eaax7881.
Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment: new opportunities and challenges.
- Tumor Immunotherapy and Microenvironment
2019 Sep. Cells.8(9).
Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints.
- Tumor Immunotherapy and Microenvironment
2019 Aug. Cancer Lett.458:13-20. Epub 2019 May 25.
The distinct roles of CXCR3 variants and their ligands in the tumor microenvironment.
- Immuno-Pharmacology and Interactomics
- Tumor Immunotherapy and Microenvironment
- NORLUX Neuro-Oncology Laboratory
2019 Jun. Cells.8(6).
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide.
- Tumor Immunotherapy and Microenvironment
- NORLUX Neuro-Oncology Laboratory
2019 Apr. Int J Cancer.144(7):1735-1745. Epub 2018 Dec 11.
Actin cytoskeleton remodeling drives breast cancer cell escape from natural killer-mediated cytotoxicity.
- Cytoskeleton and Cancer Progression
- Platform National Cytometry
- NORLUX Neuro-Oncology Laboratory
- Tumor Immunotherapy and Microenvironment
2018 Oct. Cancer Res.78(19):5631-5643. Epub 2018 Aug 13.
Driving cytotoxic natural killer cells into melanoma: If CCL5 plays the music, autophagy calls the shots.
- Tumor Immunotherapy and Microenvironment
- Immuno-Pharmacology and Interactomics
- Allergy and Clinical Immunology
2018 Sep. Crit Rev Oncog.23(5-6):321-332.
Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2.
- Cytoskeleton and Cancer Progression
- Tumor Immunotherapy and Microenvironment
2018 Jul. Sci Rep.8(1):10191.
High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia.
- Tumor Stroma Interactions
- Tumor Immunotherapy and Microenvironment
2018 May. OncoImmunology.7(8):e1465167.
Inhibition of HIF1alpha-dependent upregulation of Phospho-l-Plastin resensitizes multiple myeloma cells to frontline therapy.
- Tumor Immunotherapy and Microenvironment
- Computational Biomedicine
- Laboratory of Oncolytic-Virus-Immuno-Therapeutics
2018 May. Int J Mol Sci.19(6):1551.
Targeting autophagy in the tumor microenvironment: New challenges and opportunities for regulating tumor immunity.
- Tumor Immunotherapy and Microenvironment
2018 Apr. Front Immunol.9:887.
Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target.
- Tumor Immunotherapy and Microenvironment
- Tumor Stroma Interactions
2018 Apr. OncoImmunology.7(8):e1452583.
Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.
- Tumor Stroma Interactions
- Platform National Cytometry
- Tumor Immunotherapy and Microenvironment
- NORLUX Neuro-Oncology Laboratory
- Allergy and Clinical Immunology
2018 Apr. Blood.131(14):1617-1621. Epub 2018 Feb 13.
Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield.
- Tumor Immunotherapy and Microenvironment
2018 Mar. Autophagy.14(4):730-732. Epub 2018 Mar 11.