Arnaud Muller

Latest publications

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Quantitative Biology Unit
  • Proteomics of Cellular Signaling
December 11, 2020
2020 Dec. Nat Commun.11(1):6366.
By:
  • Schuster A
  • Klein E
  • Neirinckx V
  • Knudsen AM
  • Fabian C
  • Hau AC
  • Dieterle M
  • Oudin A
  • Nazarov PV
  • Golebiewska A
  • Muller A
  • Perez-Hernandez D
  • Rodius S
  • Dittmar G
  • Bjerkvig R
  • Herold-Mende C
  • Klink B
  • Kristensen BW
  • Niclou SP.

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.

Temozolomide-induced RNA interactome uncovers novel lncRNA regulatory loops in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Quantitative Biology Unit
  • DNA Repair and Chemoresistance
September 10, 2020
2020 Sep. Cancers.12(9).
By:
  • Fritah S
  • Muller A
  • Jiang W
  • Mitra R
  • Sarmini M
  • Dieterle M
  • Golebiewska A
  • Ye T
  • Van Dyck E
  • Herold-Mende C
  • Zhao Z
  • Azuaje F
  • Niclou SP.

Community assessment of the predictability of cancer protein and phosphoprotein levels from genomics and transcriptomics.

  • Multiomics Data Science
  • Quantitative Biology Unit
August 26, 2020
2020 Aug. Cell Syst.11(2):186-195 e9. Epub 2020 Jul 24.
By:
  • Yang M
  • Petralia F
  • Li Z
  • Li H
  • Ma W
  • Song X
  • Kim S
  • Lee H
  • Yu H
  • Lee B
  • Bae S
  • Heo E
  • Kaczmarczyk J
  • Stępniak P
  • Warchoł M
  • Yu T
  • Calinawan AP
  • Boutros PC
  • Payne SH
  • Reva B
  • NCI-CPTAC-DREAM Consortium (Azuaje F. KT
  • Kim S.
  • Muller A.
  • Nazarov P.
  • Tranchevent L. as collaborators)
  • Boja E
  • Rodriguez H
  • Stolovitzky G
  • Guan Y
  • Kang J
  • Wang P
  • Fenyö D
  • Saez-Rodriguez J.

Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
July 30, 2020
2020 Jul. F1000Res.7:1906.
By:
  • Azuaje F
  • Kaoma T
  • Jeanty C
  • Nazarov PV
  • Muller A
  • Kim SY
  • Dittmar G
  • Golebiewska A
  • Niclou SP.

Deconvolution of “big data” in cancer genomics: from pancancer level to single cells. In Computer Technologies and Data Analysis (CTDA'2020) : Materials of II International Scientific-Practical Conference, Minsk, 23-24 April, 2020. (Book Chapter)

  • Multiomics Data Science
  • Computational Biomedicine
  • Quantitative Biology Unit
July 09, 2020
2020 Jul. Bishkek VA and Skakun V, eds. Minsk: BSU, 2020. p.7-11. ISBN 978-985-566-942-6.
By:
  • Chepeleva M
  • Wang Y
  • Kakoichankava A
  • Muller A
  • Kaoma T
  • Nazarov PV.

Standardization of the preanalytical phase of DNA extraction from fixed tissue for next-generation sequencing analyses.

  • Integrated BioBank of Luxembourg
  • Quantitative Biology Unit
January 25, 2020
2020 Jan. N Biotechnol.54:52-61. Epub 2019 Aug 6.
By:
  • Kofanova O
  • Bellora C
  • Garcia Frasquilho S
  • Antunes L
  • Hamot G
  • Mathay C
  • Mommaerts K
  • Muller A
  • DeWitt B
  • Betsou F.

Deconvolution of transcriptomes and miRNomes by independent component analysis provides insights into biological processes and clinical outcomes of melanoma patients.

  • Multiomics Data Science
  • Computational Biomedicine
  • Proteomics of Cellular Signaling
September 18, 2019
2019 Sep. BMC Med Genomics.12(1):132.
By:
  • Nazarov PV
  • Wienecke-Baldacchino AK
  • Zinovyev A
  • Czerwinska U
  • Muller A
  • Nashan D
  • Dittmar G
  • Azuaje F
  • Kreis S.

Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.

  • Computational Biomedicine
  • NORLUX Neuro-Oncology Laboratory
July 01, 2019
2019 Jul. Neuro Oncol.21(7):890–900.
By:
  • Hossain JA
  • Latif MA
  • Ystaas LAR
  • Ninzima S
  • Riecken K
  • Muller A
  • Azuaje F
  • Joseph JV
  • Talasila KM
  • Ghimire J
  • Fehse B
  • Bjerkvig R
  • Miletic H.

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

  • Luxembourg Center of Neuropathology
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
July 01, 2019
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
By:
  • Zeiner PS
  • Preusse C
  • Golebiewska A
  • Zinke J
  • Iriondo A
  • Muller A
  • Kaoma T
  • Filipski K
  • Muller-Eschner M
  • Bernatz S
  • Blank AE
  • Baumgarten P
  • Ilina E
  • Grote A
  • Hansmann ML
  • Verhoff MA
  • Franz K
  • Feuerhake F
  • Steinbach JP
  • Wischhusen J
  • Stenzel W
  • Niclou SP
  • Harter PN
  • Mittelbronn M.

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Competence Center for Methodology and Statistics
  • Platform National Cytometry
April 16, 2019
2019 Apr. Nat Commun.10(1):1787.
By:
  • Dirkse A
  • Golebiewska A
  • Buder T
  • Nazarov PV
  • Muller A
  • Poovathingal S
  • Brons NHC
  • Leite S
  • Sauvageot N
  • Sarkisjan D
  • Seyfrid M
  • Fritah S
  • Stieber D
  • Michelucci A
  • Hertel F
  • Herold-Mende C
  • Azuaje F
  • Skupin A
  • Bjerkvig R
  • Deutsch A
  • Voss-Bohme A
  • Niclou SP.

PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPbeta.

  • Proteomics of Cellular Signaling
March 29, 2019
2019 Mar. iScience.13:351-370. Epub 2019 Mar 1.
By:
  • Dittmar G
  • Hernandez DP
  • Kowenz-Leutz E
  • Kirchner M
  • Kahlert G
  • Wesolowski R
  • Baum K
  • Knoblich M
  • Hofstatter M
  • Muller A
  • Wolf J
  • Reimer U
  • Leutz A.

Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach.

  • Computational Biomedicine
June 07, 2018
2018 Jun. Biol Direct.13(1):12.
By:
  • Tranchevent LC
  • Nazarov PV
  • Kaoma T
  • Schmartz GP
  • Muller A
  • Kim SY
  • Rajapakse JC
  • Azuaje F.

CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival.

  • Luxembourg Center of Neuropathology
  • Computational Biomedicine
March 01, 2018
2018 Mar. Acta Neuropathol Commun.6(1):18.
By:
  • Zeiner PS
  • Zinke J
  • Kowalewski DJ
  • Bernatz S
  • Tichy J
  • Ronellenfitsch MW
  • Thorsen F
  • Berger A
  • Forster MT
  • Muller A
  • Steinbach JP
  • Beschorner R
  • Wischhusen J
  • Kvasnicka HM
  • Plate KH
  • Stefanovic S
  • Weide B
  • Mittelbronn M
  • Harter PN.

Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer.

  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
March 01, 2018
2018 Mar. Int J Cancer.142(5):1010-1021. Epub 2017 Oct 17.
By:
  • Bauer AS
  • Nazarov PV
  • Giese NA
  • Beghelli S
  • Heller A
  • Greenhalf W
  • Costello E
  • Muller A
  • Bier M
  • Strobel O
  • Hackert T
  • Vallar L
  • Scarpa A
  • Buchler MW
  • Neoptolemos JP
  • Kreis S
  • Hoheisel JD.

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT.

  • Tumor Immunotherapy and Microenvironment
  • Computational Biomedicine
February 15, 2018
2018 Feb. OncoImmunology.7(4):e1345415.
By:
  • Noman MZ
  • Van Moer K
  • Marani V
  • Gemmill RM
  • Tranchevent LC
  • Azuaje F
  • Muller A
  • Chouaib S
  • Thiery JP
  • Berchem G
  • Janji B.

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • Tumor Immunotherapy and Microenvironment
September 05, 2017
2017 Sep. Br J Cancer.117(6):813-825. Epub 2017 Aug 10.
By:
  • Abdul Rahim SA
  • Dirkse A
  • Oudin A
  • Schuster A
  • Bohler J
  • Barthelemy V
  • Muller A
  • Vallar L
  • Janji B
  • Golebiewska A
  • Niclou SP.

Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

  • Luxembourg Center of Neuropathology
  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • NORLUX Neuro-Oncology Laboratory
August 01, 2017
2017 Aug. Int J Oncol.51(2):702-714. Epub 2017 Jun 21.
By:
  • Armento A
  • Ilina EI
  • Kaoma T
  • Muller A
  • Vallar L
  • Niclou SP
  • Kruger MA
  • Mittelbronn M
  • Naumann U.

RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples.

  • Computational Biomedicine
  • Platform LUXGEN - Micro-Array
  • Proteomics of Cellular Signaling
June 06, 2017
2017 Jun. BMC Genomics.18(1):443.
By:
  • Nazarov PV
  • Muller A
  • Kaoma T
  • Nicot N
  • Maximo C
  • Birembaut P
  • Tran NL
  • Dittmar G
  • Vallar L.

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.

  • Eco-Immunology and Microbiome
  • Platform LUXGEN - Micro-Array
November 17, 2016
2016 Nov. Cell.167(5):1339-1353.e21.
By:
  • Desai MS
  • Seekatz AM
  • Koropatkin NM
  • Kamada N
  • Hickey CA
  • Wolter M
  • Pudlo NA
  • Kitamoto S
  • Terrapon N
  • Muller A
  • Young VB
  • Henrissat B
  • Wilmes P
  • Stappenbeck TS
  • Nunez G
  • Martens EC.