Ann-Christin Hau

Latest publications

Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors.

  • NORLUX Neuro-Oncology Laboratory
  • Neuro-Immunology Group
  • Translational Radiomics
June 18, 2021
2021 Jun. STAR Protoc.2(2):100534.
By:
  • Oudin A
  • Baus V
  • Barthelemy V
  • Fabian C
  • Klein E
  • Dieterle M
  • Wantz M
  • Hau AC
  • Dording C
  • Bernard A
  • Michelucci A
  • Yabo YA
  • Kanli G
  • Keunen O
  • Bjerkvig R
  • Niclou SP
  • Golebiewska A.

Cystathionine-gamma-lyase drives antioxidant defense in cysteine-restricted IDH1-mutant astrocytomas.

  • NORLUX Neuro-Oncology Laboratory
  • Proteomics of Cellular Signaling
  • Quantitative Biology Unit
  • Cancer Metabolism Group
April 09, 2021
2021 Apr. Neurooncol Adv.3(1):vdab057.
By:
  • Cano-Galiano A
  • Oudin A
  • Fack F
  • Allega MF
  • Sumpton D
  • Martinez-Garcia E
  • Dittmar G
  • Hau AC
  • De Falco A
  • Herold-Mende C
  • Bjerkvig R
  • Meiser J
  • Tardito S
  • Niclou SP.

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Quantitative Biology Unit
  • Proteomics of Cellular Signaling
December 11, 2020
2020 Dec. Nat Commun.11(1):6366.
By:
  • Schuster A
  • Klein E
  • Neirinckx V
  • Knudsen AM
  • Fabian C
  • Hau AC
  • Dieterle M
  • Oudin A
  • Nazarov PV
  • Golebiewska A
  • Muller A
  • Perez-Hernandez D
  • Rodius S
  • Dittmar G
  • Bjerkvig R
  • Herold-Mende C
  • Klink B
  • Kristensen BW
  • Niclou SP.

Glioblastoma organoids: Pre-clinical applications and challenges in the context of immunotherapy.

  • NORLUX Neuro-Oncology Laboratory
December 08, 2020
2020 Dec. Front Oncol.10:604121.
By:
  • Klein E
  • Hau AC
  • Oudin A
  • Golebiewska A
  • Niclou SP.

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.

The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein-protein interaction in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Immuno-Pharmacology and Interactomics
September 06, 2019
2019 Sep. Neurooncol Adv.1(1):vdz024.
By:
  • Neirinckx V
  • Hau AC
  • Schuster A
  • Fritah S
  • Tiemann K
  • Klein E
  • Nazarov PV
  • Matagne A
  • Szpakowska M
  • Meyrath M
  • Chevigne A
  • Schmidt MHH
  • Niclou SP.

Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal AnalySiS Consortium.

  • NORLUX Neuro-Oncology Laboratory
June 18, 2018
2018 Jun. Neuro Oncol.20(7):873-884.
By:
  • Aldape K
  • Amin SB
  • Ashley DM
  • Barnholtz-Sloan JS
  • Bates AJ
  • Beroukhim R
  • Bock C
  • Brat DJ
  • Claus EB
  • Costello JF
  • de Groot JF
  • Finocchiaro G
  • French PJ
  • Gan HK
  • Griffith B
  • Herold-Mende CC
  • Horbinski C
  • Iavarone A
  • Kalkanis SN
  • Karabatsou K
  • Kim H
  • Kouwenhoven MCM
  • McDonald KL
  • Miletic H
  • Nam DH
  • Ng HK
  • Niclou SP
  • Noushmehr H
  • Ormond R
  • Poisson LM
  • Reifenberger G
  • Roncaroli F
  • Sa JK
  • Sillevis Smitt PAE
  • Smits M
  • Souza CF
  • Tabatabai G
  • Van Meir EG
  • Verhaak RGW
  • Watts C
  • Wesseling P
  • Woehrer A
  • Yung WKA
  • Jungk C
  • Hau AC
  • van Dyck E
  • Westerman BA
  • Yin J
  • Abiola O
  • Zeps N
  • Grimmond S
  • Buckland M
  • Khasraw M
  • Sulman EP
  • Muscat AM
  • Stead L
  • Glass Consortium.

Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors.

  • NORLUX Neuro-Oncology Laboratory
April 10, 2018
2018 Apr. Stem Cell Reports.10(4):1184-1192.
By:
  • Kolb J
  • Anders-Maurer M
  • Muller T
  • Hau AC
  • Grebbin BM
  • Kallenborn-Gerhardt W
  • Behrends C
  • Schulte D.

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Computational Biomedicine
December 01, 2017
2017 Dec. EMBO Mol Med.9(12):1681-1695.
By:
  • Fack F
  • Tardito S
  • Hochart G
  • Oudin A
  • Zheng L
  • Fritah S
  • Golebiewska A
  • Nazarov PV
  • Bernard A
  • Hau AC
  • Keunen O
  • Leenders W
  • Lund-Johansen M
  • Stauber J
  • Gottlieb E
  • Bjerkvig R
  • Niclou SP.

MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1.

  • NORLUX Neuro-Oncology Laboratory
September 04, 2017
2017 Sep. J Cell Biol.216(9):2715-2729. Epub 2017 Jul 24.
By:
  • Hau AC
  • Grebbin BM
  • Agoston Z
  • Anders-Maurer M
  • Muller T
  • Gross A
  • Kolb J
  • Langer JD
  • Doring C
  • Schulte D.

Pbx1 is required for adult subventricular zone neurogenesis.

  • NORLUX Neuro-Oncology Laboratory
July 01, 2016
2016 Jul. Development.143(13):2281-91. Epub 2016 May 25.
By:
  • Grebbin BM
  • Hau AC
  • Gross A
  • Anders-Maurer M
  • Schramm J
  • Koss M
  • Wille C
  • Mittelbronn M
  • Selleri L
  • Schulte D.