Alessandro Michelucci

Latest publications

Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain (COL4A6) as a novel regulator of striatal axonal branching in mice.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
August 28, 2021
2021 Aug. Genes Brain Behav.e12769. Online ahead of print.
By:
  • Thomas MH
  • Gui Y
  • Garcia P
  • Karout M
  • Gomez Ramos B
  • Jaeger C
  • Michelucci A
  • Gaigneaux A
  • Kollmus H
  • Centeno A
  • Schughart K
  • Balling R
  • Mittelbronn M
  • Nadeau JH
  • Sauter T
  • Williams RW
  • Sinkkonen L
  • Buttini M.
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Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors.

  • NORLUX Neuro-Oncology Laboratory
  • Neuro-Immunology Group
  • Translational Radiomics
June 18, 2021
2021 Jun. STAR Protoc.2(2):100534.
By:
  • Oudin A
  • Baus V
  • Barthelemy V
  • Fabian C
  • Klein E
  • Dieterle M
  • Wantz M
  • Hau AC
  • Dording C
  • Bernard A
  • Michelucci A
  • Yabo YA
  • Kanli G
  • Keunen O
  • Bjerkvig R
  • Niclou SP
  • Golebiewska A.
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NF-kappaB and TNF affect the astrocytic differentiation from neural stem cells.

  • Neuro-Immunology Group
April 08, 2021
2021 Apr. Cells.10(4):840.
By:
  • Birck C
  • Ginolhac A
  • Pavlou MAS
  • Michelucci A
  • Heuschling P
  • Grandbarbe L.
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Microglia in health and disease: The strength to be diverse and reactive.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
March 31, 2021
2021 Mar. Front Cell Neurosci.660523.
By:
  • Uriarte Huarte O
  • Richart L
  • Mittelbronn M
  • Michelucci A.
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Single-cell transcriptomics and in situ morphological analyses reveal microglia heterogeneity across the nigrostriatal pathway.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
March 11, 2021
2021 Mar. Front Immunol.12:639613.
By:
  • Uriarte Huarte O
  • Kyriakis D
  • Heurtaux T
  • Pires-Afonso Y
  • Grzyb K
  • Halder R
  • Buttini M
  • Skupin A
  • Mittelbronn M
  • Michelucci A.
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Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.
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Pituitary tumor transforming gene 1 orchestrates gene regulatory variation in mouse ventral midbrain during aging.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
September 23, 2020
2020 Sep. Front Genet.11(1119).
By:
  • Gui Y
  • Thomas MH
  • Garcia P
  • Karout M
  • Halder R
  • Michelucci A
  • Kollmus H
  • Zhou C
  • Melmed S
  • Schughart K
  • Balling R
  • Mittelbronn M
  • Nadeau JH
  • Williams RW
  • Sauter T
  • Buttini M
  • Sinkkonen L.
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Revealing and harnessing tumour-associated microglia/macrophage heterogeneity in glioblastoma.

  • Neuro-Immunology Group
  • NORLUX Neuro-Oncology Laboratory
January 21, 2020
2020 Jan. Int J Mol Sci.21(3):E689.
By:
  • Pires-Afonso Y
  • Niclou SP
  • Michelucci A.
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Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
  • Competence Center for Methodology and Statistics
  • Platform National Cytometry
April 16, 2019
2019 Apr. Nat Commun.10(1):1787.
By:
  • Dirkse A
  • Golebiewska A
  • Buder T
  • Nazarov PV
  • Muller A
  • Poovathingal S
  • Brons NHC
  • Leite S
  • Sauvageot N
  • Sarkisjan D
  • Seyfrid M
  • Fritah S
  • Stieber D
  • Michelucci A
  • Hertel F
  • Herold-Mende C
  • Azuaje F
  • Skupin A
  • Bjerkvig R
  • Deutsch A
  • Voss-Bohme A
  • Niclou SP.
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Transcriptional and epigenetic mechanisms underlying astrocyte identity.

  • NORLUX Neuro-Oncology Laboratory
March 01, 2019
2019 Mar. Prog Neurobiol.174:36-52. Epub 2018 Dec 29.
By:
  • Pavlou MAS
  • Grandbarbe L
  • Buckley NJ
  • Niclou SP
  • Michelucci A.
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The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity.

  • NORLUX Neuro-Oncology Laboratory
January 08, 2019
2019 Jan. Cell Metab.29(1):211-220 e5. Epub 2018 Oct 4.
By:
  • Dominguez-Andres J
  • Novakovic B
  • Li Y
  • Scicluna BP
  • Gresnigt MS
  • Arts RJW
  • Oosting M
  • Moorlag S
  • Groh LA
  • Zwaag J
  • Koch RM
  • Ter Horst R
  • Joosten LAB
  • Wijmenga C
  • Michelucci A
  • van der Poll T
  • Kox M
  • Pickkers P
  • Kumar V
  • Stunnenberg H
  • Netea MG.
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Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.

  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
November 01, 2018
2018 Nov. EMBO Rep.19(11). Epub 2018 Sep 11.
By:
  • Sousa C
  • Golebiewska A
  • Poovathingal SK
  • Kaoma T
  • Pires-Afonso Y
  • Martina S
  • Coowar D
  • Azuaje F
  • Skupin A
  • Balling R
  • Biber K
  • Niclou SP
  • Michelucci A.
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Microglia in health and disease: A unique immune cell population. (Book)

  • NORLUX Neuro-Oncology Laboratory
  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. Michelucci A, Mittelbronn M and Gomez-Nicola D, eds. Lausanne: Frontiers Media, 2018. 106 p. (Frontiers Research topic). ISBN 978-2-88945-601-7.
By:
  • Michelucci A
  • Mittelbronn M
  • Gomez-Nicola D
  • et al.
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Microglia in health and disease: a unique immune cell population.

  • NORLUX Neuro-Oncology Laboratory
  • Luxembourg Center of Neuropathology
August 15, 2018
2018 Aug. Front Immunol.9:1779.
By:
  • Michelucci A
  • Mittelbronn M
  • Gomez-Nicola D.
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Integrative computational network analysis reveals site-specific mediators of inflammation in Alzheimer's disease.

  • NORLUX Neuro-Oncology Laboratory
March 02, 2018
2018 Mar. Front Physiol.9:154.
By:
  • Ravichandran S
  • Michelucci A
  • Del Sol A.
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Cellular and molecular characterization of microglia: A unique immune cell population.

  • NORLUX Neuro-Oncology Laboratory
March 02, 2017
2017 Mar. Front Immunol.8:198.
By:
  • Sousa C
  • Biber K
  • Michelucci A.
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Inflammation promotes a conversion of astrocytes into neural progenitor cells via NF-kappaB activation.

  • NORLUX Neuro-Oncology Laboratory
October 01, 2016
2016 Oct. Mol Neurobiol.53(8):5041-55. Epub 2015 Sep 17.
By:
  • Gabel S
  • Koncina E
  • Dorban G
  • Heurtaux T
  • Birck C
  • Glaab E
  • Michelucci A
  • Heuschling P
  • Grandbarbe L.
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The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.

  • NORLUX Neuro-Oncology Laboratory
August 01, 2016
2016 Aug. Mol Neurobiol.53(6):3724-3739. Epub 2015 Jul 4.
By:
  • Michelucci A
  • Bithell A
  • Burney MJ
  • Johnston CE
  • Wong KY
  • Teng SW
  • Desai J
  • Gumbleton N
  • Anderson G
  • Stanton LW
  • Williams BP
  • Buckley NJ.
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Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels.

  • NORLUX Neuro-Oncology Laboratory
July 01, 2016
2016 Jul. J Biol Chem.291(27):14274-84. Epub 2016 May 9.
By:
  • Cordes T
  • Wallace M
  • Michelucci A
  • Divakaruni AS
  • Sapcariu SC
  • Sousa C
  • Koseki H
  • Cabrales P
  • Murphy AN
  • Hiller K
  • Metallo CM.
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Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism.

  • NORLUX Neuro-Oncology Laboratory
May 01, 2016
2016 May. Neurobiol Dis.89:112-25. Epub 2016 Feb 1.
By:
  • Meiser J
  • Delcambre S
  • Wegner A
  • Jager C
  • Ghelfi J
  • d'Herouel AF
  • Dong X
  • Weindl D
  • Stautner C
  • Nonnenmacher Y
  • Michelucci A
  • Popp O
  • Giesert F
  • Schildknecht S
  • Kramer L
  • Schneider JG
  • Woitalla D
  • Wurst W
  • Skupin A
  • Weisenhorn DM
  • Kruger R
  • Leist M
  • Hiller K.
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