The Role of DJ-1 in cellular metabolism and pathophysiological implications for Parkinson's disease.

  • Transversal Translational Medicine
  • Integrated BioBank of Luxembourg
February 07, 2021 By:
  • Mencke P
  • Boussaad I
  • Romano CD
  • Kitami T
  • Linster CL
  • Kruger R.

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson s disease.

2021 Feb. Cells.10(2).
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